Mutational analysis of Rift Valley fever phlebovirus nucleocapsid protein indicates novel conserved, functional amino acids

Rift Valley fever phlebovirus (RVFV; Phenuiviridae, Phlebovirus) is an important mosquito-borne pathogen of both humans and ruminants. The RVFV genome is composed of tripartite, single stranded, negative or ambisense RNAs. The small (S) segment encodes both the nucleocapsid protein (N) and the non-s...

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Veröffentlicht in:	PLoS neglected tropical diseases Jg. 11; H. 12; S. e0006155
Hauptverfasser:	Mottram, Timothy J., Li, Ping, Dietrich, Isabelle, Shi, Xiaohong, Brennan, Benjamin, Varjak, Margus, Kohl, Alain
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	United States Public Library of Science 21.12.2017 Public Library of Science (PLoS)
Schlagworte:	Amino Acid Sequence Amino acids Analysis Animals Antiviral agents Aquatic insects Biology and life sciences Capacity Cell Line Coccidioidomycosis Cricetinae DNA Mutational Analysis DNA-directed RNA polymerase Encapsidation Gene mutation Gene sequencing Genetic aspects Genome, Viral - genetics Genomes Health aspects Interactions Life cycle Life cycle engineering Life cycles Medicine and health sciences N protein Nucleic acids Nucleocapsid Proteins - genetics Nucleocapsids Packaging Protein Multimerization - genetics Protein Multimerization - physiology Proteins Research and Analysis Methods Ribonucleic acid Rift Valley fever Rift Valley Fever - virology Rift Valley fever virus - genetics Risk factors RNA RNA, Viral - genetics RNA-Binding Proteins - genetics RNA-directed RNA polymerase Sequence Alignment Transcription Tropical diseases Vector-borne diseases Viral diseases Viral infections Virology Virus Replication Viruses
ISSN:	1935-2735, 1935-2727, 1935-2735
Online-Zugang:	Volltext
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