Optimization of Codon Translation Rates via tRNA Modifications Maintains Proteome Integrity

Proteins begin to fold as they emerge from translating ribosomes. The kinetics of ribosome transit along a given mRNA can influence nascent chain folding, but the extent to which individual codon translation rates impact proteome integrity remains unknown. Here, we show that slower decoding of discr...

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Vydané v:	Cell Ročník 161; číslo 7; s. 1606
Hlavní autori:	Nedialkova, Danny D, Leidel, Sebastian A
Médium:	Journal Article
Jazyk:	English
Vydavateľské údaje:	United States 18.06.2015
Predmet:	Animals Caenorhabditis elegans - cytology Caenorhabditis elegans - genetics Caenorhabditis elegans - metabolism Codon Protein Aggregates Protein Biosynthesis Ribosomes - metabolism RNA, Transfer - metabolism Saccharomyces cerevisiae - cytology Saccharomyces cerevisiae - genetics Saccharomyces cerevisiae - metabolism Stress, Physiological Uridine - genetics
ISSN:	1097-4172, 1097-4172
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