Co-transcriptional DNA and RNA Cleavage during Type III CRISPR-Cas Immunity
Immune systems must recognize and destroy different pathogens that threaten the host. CRISPR-Cas immune systems protect prokaryotes from viral and plasmid infection utilizing small CRISPR RNAs that are complementary to the invader's genome and specify the targets of RNA-guided Cas nucleases. Ty...
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| Vydáno v: | Cell Ročník 161; číslo 5; s. 1164 |
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| Hlavní autoři: | , , , , , |
| Médium: | Journal Article |
| Jazyk: | angličtina |
| Vydáno: |
United States
21.05.2015
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| Témata: | |
| ISSN: | 1097-4172, 1097-4172 |
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| Abstract | Immune systems must recognize and destroy different pathogens that threaten the host. CRISPR-Cas immune systems protect prokaryotes from viral and plasmid infection utilizing small CRISPR RNAs that are complementary to the invader's genome and specify the targets of RNA-guided Cas nucleases. Type III CRISPR-Cas immunity requires target transcription, and whereas genetic studies demonstrated DNA targeting, in vitro data have shown crRNA-guided RNA cleavage. The molecular mechanism behind these disparate activities is not known. Here, we show that transcription across the targets of the Staphylococcus epidermidis type III-A CRISPR-Cas system results in the cleavage of the target DNA and its transcripts, mediated by independent active sites within the Cas10-Csm ribonucleoprotein effector complex. Immunity against plasmids and DNA viruses requires DNA, but not RNA, cleavage activity. Our studies reveal a highly versatile mechanism of CRISPR immunity that can defend microorganisms against diverse DNA and RNA invaders. |
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| AbstractList | Immune systems must recognize and destroy different pathogens that threaten the host. CRISPR-Cas immune systems protect prokaryotes from viral and plasmid infection utilizing small CRISPR RNAs that are complementary to the invader's genome and specify the targets of RNA-guided Cas nucleases. Type III CRISPR-Cas immunity requires target transcription, and whereas genetic studies demonstrated DNA targeting, in vitro data have shown crRNA-guided RNA cleavage. The molecular mechanism behind these disparate activities is not known. Here, we show that transcription across the targets of the Staphylococcus epidermidis type III-A CRISPR-Cas system results in the cleavage of the target DNA and its transcripts, mediated by independent active sites within the Cas10-Csm ribonucleoprotein effector complex. Immunity against plasmids and DNA viruses requires DNA, but not RNA, cleavage activity. Our studies reveal a highly versatile mechanism of CRISPR immunity that can defend microorganisms against diverse DNA and RNA invaders. Immune systems must recognize and destroy different pathogens that threaten the host. CRISPR-Cas immune systems protect prokaryotes from viral and plasmid infection utilizing small CRISPR RNAs that are complementary to the invader's genome and specify the targets of RNA-guided Cas nucleases. Type III CRISPR-Cas immunity requires target transcription, and whereas genetic studies demonstrated DNA targeting, in vitro data have shown crRNA-guided RNA cleavage. The molecular mechanism behind these disparate activities is not known. Here, we show that transcription across the targets of the Staphylococcus epidermidis type III-A CRISPR-Cas system results in the cleavage of the target DNA and its transcripts, mediated by independent active sites within the Cas10-Csm ribonucleoprotein effector complex. Immunity against plasmids and DNA viruses requires DNA, but not RNA, cleavage activity. Our studies reveal a highly versatile mechanism of CRISPR immunity that can defend microorganisms against diverse DNA and RNA invaders.Immune systems must recognize and destroy different pathogens that threaten the host. CRISPR-Cas immune systems protect prokaryotes from viral and plasmid infection utilizing small CRISPR RNAs that are complementary to the invader's genome and specify the targets of RNA-guided Cas nucleases. Type III CRISPR-Cas immunity requires target transcription, and whereas genetic studies demonstrated DNA targeting, in vitro data have shown crRNA-guided RNA cleavage. The molecular mechanism behind these disparate activities is not known. Here, we show that transcription across the targets of the Staphylococcus epidermidis type III-A CRISPR-Cas system results in the cleavage of the target DNA and its transcripts, mediated by independent active sites within the Cas10-Csm ribonucleoprotein effector complex. Immunity against plasmids and DNA viruses requires DNA, but not RNA, cleavage activity. Our studies reveal a highly versatile mechanism of CRISPR immunity that can defend microorganisms against diverse DNA and RNA invaders. |
| Author | Pyenson, Nora Marraffini, Luciano A Jiang, Wenyan Goldberg, Gregory W Samai, Poulami Hatoum-Aslan, Asma |
| Author_xml | – sequence: 1 givenname: Poulami surname: Samai fullname: Samai, Poulami organization: Laboratory of Bacteriology, The Rockefeller University, 1230 York Avenue, New York, NY 10065, USA – sequence: 2 givenname: Nora surname: Pyenson fullname: Pyenson, Nora organization: Laboratory of Bacteriology, The Rockefeller University, 1230 York Avenue, New York, NY 10065, USA – sequence: 3 givenname: Wenyan surname: Jiang fullname: Jiang, Wenyan organization: Laboratory of Bacteriology, The Rockefeller University, 1230 York Avenue, New York, NY 10065, USA – sequence: 4 givenname: Gregory W surname: Goldberg fullname: Goldberg, Gregory W organization: Laboratory of Bacteriology, The Rockefeller University, 1230 York Avenue, New York, NY 10065, USA – sequence: 5 givenname: Asma surname: Hatoum-Aslan fullname: Hatoum-Aslan, Asma organization: Laboratory of Bacteriology, The Rockefeller University, 1230 York Avenue, New York, NY 10065, USA – sequence: 6 givenname: Luciano A surname: Marraffini fullname: Marraffini, Luciano A email: marraffini@rockefeller.edu organization: Laboratory of Bacteriology, The Rockefeller University, 1230 York Avenue, New York, NY 10065, USA. Electronic address: marraffini@rockefeller.edu |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/25959775$$D View this record in MEDLINE/PubMed |
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| PublicationYear | 2015 |
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| Snippet | Immune systems must recognize and destroy different pathogens that threaten the host. CRISPR-Cas immune systems protect prokaryotes from viral and plasmid... |
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| SubjectTerms | Clustered Regularly Interspaced Short Palindromic Repeats CRISPR-Cas Systems DNA - genetics DNA - metabolism Ribonucleoproteins - metabolism RNA - genetics RNA - metabolism Staphylococcus epidermidis - immunology Staphylococcus epidermidis - metabolism Staphylococcus epidermidis - virology Transcription, Genetic |
| Title | Co-transcriptional DNA and RNA Cleavage during Type III CRISPR-Cas Immunity |
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