PI3K regulates MEK/ERK signaling in breast cancer via the Rac-GEF, P-Rex1

The PI3K pathway is genetically altered in excess of 70% of breast cancers, largely through PIK3CA mutation and HER2 amplification. Preclinical studies have suggested that these subsets of breast cancers are particularly sensitive to PI3K inhibitors; however, the reasons for this heightened sensitiv...

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Vydané v:	Proceedings of the National Academy of Sciences - PNAS Ročník 110; číslo 52; s. 21124
Hlavní autori:	Ebi, Hiromichi, Costa, Carlotta, Faber, Anthony C, Nishtala, Madhuri, Kotani, Hiroshi, Juric, Dejan, Della Pelle, Patricia, Song, Youngchul, Yano, Seiji, Mino-Kenudson, Mari, Benes, Cyril H, Engelman, Jeffrey A
Médium:	Journal Article
Jazyk:	English
Vydavateľské údaje:	United States 24.12.2013
Predmet:	Animals Breast Neoplasms - physiopathology Class I Phosphatidylinositol 3-Kinases Computational Biology Databases, Genetic Female Guanine Nucleotide Exchange Factors - metabolism Immunoblotting MAP Kinase Signaling System - drug effects MAP Kinase Signaling System - physiology Mice Mice, Nude Neuropeptides - metabolism Phosphatidylinositol 3-Kinases - genetics Phosphatidylinositol 3-Kinases - metabolism Phosphoinositide-3 Kinase Inhibitors rac1 GTP-Binding Protein - metabolism Receptor, ErbB-2 - genetics
ISSN:	1091-6490, 1091-6490
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