PI3K regulates MEK/ERK signaling in breast cancer via the Rac-GEF, P-Rex1

The PI3K pathway is genetically altered in excess of 70% of breast cancers, largely through PIK3CA mutation and HER2 amplification. Preclinical studies have suggested that these subsets of breast cancers are particularly sensitive to PI3K inhibitors; however, the reasons for this heightened sensitiv...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS Jg. 110; H. 52; S. 21124
Hauptverfasser:	Ebi, Hiromichi, Costa, Carlotta, Faber, Anthony C, Nishtala, Madhuri, Kotani, Hiroshi, Juric, Dejan, Della Pelle, Patricia, Song, Youngchul, Yano, Seiji, Mino-Kenudson, Mari, Benes, Cyril H, Engelman, Jeffrey A
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	United States 24.12.2013
Schlagworte:	Animals Breast Neoplasms - physiopathology Class I Phosphatidylinositol 3-Kinases Computational Biology Databases, Genetic Female Guanine Nucleotide Exchange Factors - metabolism Immunoblotting MAP Kinase Signaling System - drug effects MAP Kinase Signaling System - physiology Mice Mice, Nude Neuropeptides - metabolism Phosphatidylinositol 3-Kinases - genetics Phosphatidylinositol 3-Kinases - metabolism Phosphoinositide-3 Kinase Inhibitors rac1 GTP-Binding Protein - metabolism Receptor, ErbB-2 - genetics
ISSN:	1091-6490, 1091-6490
Online-Zugang:	Weitere Angaben
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!