Cytomegalovirus seropositivity is associated with glucose regulation in the oldest old. Results from the Leiden 85-plus Study

Background Cytomegalovirus (CMV) infection has been reported to contribute to the pathogenesis of type 1 diabetes and post-transplantation diabetes. However, CMV infection has not been evaluated as a possible risk factor for type 2 diabetes. Our aim was to investigate potential associations between...

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Published in:Immunity & ageing Vol. 9; no. 1; p. 18
Main Authors: Chen, Sijia, JM de Craen, Anton, Raz, Yotam, Derhovanessian, Evelyna, Vossen CTM, Ann, Westendorp GJ, Rudi, Pawelec, Graham, Maier, Andrea B
Format: Journal Article
Language:English
Published: London BioMed Central 28.08.2012
BioMed Central Ltd
Springer Nature B.V
BMC
Subjects:
Aging
Analysis
Antibodies
Biomedical and Life Sciences
Biomedicine
Blood sugar
C-reactive protein
Cancer
Chronic obstructive pulmonary disease
Clinical Nutrition
Cytomegalovirus
Cytomegalovirus infections
Cytomegaloviruses
Development and progression
Dextrose
Diabetes
Elderly
Geriatrics/Gerontology
Glucose
Glycosylated hemoglobin
HbA1c
Health aspects
IgG antibody level
Immunoglobulin G
Immunology
Infection
Insulin resistance
Non-fasting glucose
Oldest olds
Public Health
Risk factors
Seropositivity
Type 1 diabetes
Type 2 diabetes
Type 2 diabetes
Cytomegalovirus
Seropositivity
C-reactive protein
Non-fasting glucose
Oldest olds
IgG antibody level
HbA1c
Elderly
ISSN:1742-4933, 1742-4933
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Summary:Background Cytomegalovirus (CMV) infection has been reported to contribute to the pathogenesis of type 1 diabetes and post-transplantation diabetes. However, CMV infection has not been evaluated as a possible risk factor for type 2 diabetes. Our aim was to investigate potential associations between CMV seropositivity, CMV IgG antibody level and glucose regulation in the oldest old. Results CMV seropositive subjects were more likely to have type 2 diabetes (17.2% vs 7.9%, p = 0.016), had a higher level of HbA1c (p = 0.014) and higher non-fasting glucose (p = 0.024) in the oldest olds. These associations remained significant after adjustment for possible confounders. CMV IgG antibody level was not significantly associated with glucose regulation (all p > 0.05). Conclusions In the oldest old, CMV seropositivity is significantly associated with various indicators of glucose regulation. This finding suggests that CMV infection might be a risk factor for the development of type 2 diabetes in the elderly.
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ISSN:1742-4933
1742-4933
DOI:10.1186/1742-4933-9-18