Safety and efficacy of cognitive training plus epigallocatechin-3-gallate in young adults with Down's syndrome (TESDAD): a double-blind, randomised, placebo-controlled, phase 2 trial

Early cognitive intervention is the only routine therapeutic approach used for amelioration of intellectual deficits in individuals with Down's syndrome, but its effects are limited. We hypothesised that administration of a green tea extract containing epigallocatechin-3-gallate (EGCG) would im...

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Bibliographic Details
Published in:	Lancet neurology Vol. 15; no. 8; pp. 801 - 810
Main Authors:	de la Torre, Rafael, de Sola, Susana, Hernandez, Gimena, Farré, Magí, Pujol, Jesus, Rodriguez, Joan, Espadaler, Josep María, Langohr, Klaus, Cuenca-Royo, Aida, Principe, Alessandro, Xicota, Laura, Janel, Nathalie, Catuara-Solarz, Silvina, Sanchez-Benavides, Gonzalo, Bléhaut, Henri, Dueñas-Espín, Iván, del Hoyo, Laura, Benejam, Bessy, Blanco-Hinojo, Laura, Videla, Sebastiá, Fitó, Montserrat, Delabar, Jean Maurice, Dierssen, Mara
Format:	Journal Article Publication
Language:	English
Published:	England Elsevier Ltd 01.07.2016 Elsevier Limited
Subjects:	60 Probability theory and stochastic processes 60C05 Combinatorial probability Adaptation, Psychological - drug effects Adult Alzheimer's disease Brain Catechin - analogs & derivatives Catechin - therapeutic use Cholesterol - metabolism Classificació AMS Clinical trials Cognition & reasoning Cognition Disorders - drug therapy Cognition Disorders - etiology Cognition Disorders - rehabilitation Cognitive ability Cognitive Therapy Combinatorial probabilities Comorbidity Deficits Dietary supplements Double-Blind Method Down syndrome Down Syndrome - complications Down Syndrome - drug therapy Down Syndrome - rehabilitation DYRK1A Expression Female Follow-Up Studies Green tea polyphenols Growth hormones Homocysteine - metabolism Humans Inhibition (Psychology) Intellectual disabilities Kinase Male Matemàtiques i estadística Medical imaging Memory Mental disorders Metabolism Mouse models Neurology Neuroprotective Agents - therapeutic use Probabilitat Probabilitats Recognition (Psychology) - drug effects Rescue Retrospective Studies Spain Tea Treatment Outcome Young Adult Àrees temàtiques de la UPC
ISSN:	1474-4422, 1474-4465, 1474-4465
Online Access:	Get full text
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