Role of the mechanical microenvironment in cancer development and progression

Cross-talk between tumor cells and mechanical stress in the tumor microenvironment has been shown to be involved in carcinogenesis. High mechanical stress in tumors can alter the metabolism and behaviors of cancer cells and cause cancer cells to attain cancer stem-like cell properties, thus driving...

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Podrobná bibliografia
Vydané v:	Cancer biology & medicine Ročník 17; číslo 2; s. 282 - 292
Hlavní autori:	Liu, Qiuping, Luo, Qing, Ju, Yang, Song, Guanbin
Médium:	Journal Article
Jazyk:	English
Vydavateľské údaje:	China Chinese Anti-Cancer Association (CACA), Cancer Biology & Medicine 15.05.2020 Key Laboratory of Biorheological Science and Technology, Ministry of Education, College of Bioengineering, Chongqing University, Chongqing 400030, China%Department of Mechanical Science and Engineering, Nagoya University, Nagoya 464-8603, Japan Compuscript China Anti-Cancer Association
Predmet:	Breast cancer Cancer cancer stem cell Cancer therapies Carcinogenesis Cell adhesion & migration Cell growth cell metabolism Fibroblasts Gastric cancer Hypoxia Liver mechanical force Mechanotransduction Medical research Metabolism Metastases Metastasis Phosphorylation Review Roles Signal transduction Stem cells Tumor cells tumor progression Tumorigenesis Tumors Cancer stem cell cell metabolism tumor progression mechanical force
ISSN:	2095-3941
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Popis
Shrnutí:	Cross-talk between tumor cells and mechanical stress in the tumor microenvironment has been shown to be involved in carcinogenesis. High mechanical stress in tumors can alter the metabolism and behaviors of cancer cells and cause cancer cells to attain cancer stem-like cell properties, thus driving tumor progression and promoting metastasis. The mechanical signal is converted into a biochemical signal that activates tumorigenic signaling pathways through mechanotransduction. Herein, we describe the physical changes occurring during reprogramming of cancer cell metabolism, which regulate cancer stem cell functions and promote tumor progression and aggression. Furthermore, we highlight emerging therapeutic strategies targeting mechanotransduction signaling pathways.
Bibliografia:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 ObjectType-Review-3 content type line 23
ISSN:	2095-3941
DOI:	10.20892/j.issn.2095-3941.2019.0437