Normalizing the environment recapitulates adult human immune traits in laboratory mice

The immune system of laboratory mice raised in an ultra-hygienic environment resembles that ofnewborn humans, but can be induced to resemble the immune system of adult humans or 'dirty' mice by co-housing with pet store-bought mice. Do 'dirty' mice make better immunological model...

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Veröffentlicht in:	Nature (London) Jg. 532; H. 7600; S. 512 - 516
Hauptverfasser:	Beura, Lalit K., Hamilton, Sara E., Bi, Kevin, Schenkel, Jason M., Odumade, Oludare A., Casey, Kerry A., Thompson, Emily A., Fraser, Kathryn A., Rosato, Pamela C., Filali-Mouhim, Ali, Sekaly, Rafick P., Jenkins, Marc K., Vezys, Vaiva, Haining, W. Nicholas, Jameson, Stephen C., Masopust, David
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	London Nature Publishing Group UK 28.04.2016 Nature Publishing Group
Schlagworte:	13/31 14/63 38/61 631/250/2520 631/250/254 Adult Animal Husbandry - methods Animals Animals, Laboratory - immunology Animals, Wild - immunology Antigens Biomedical research Cell Differentiation Disease Environment Environmental changes Environmental effects Environmental Exposure Female Gene expression Humanities and Social Sciences Humans Immune system Immune System - immunology Immunity Immunity - immunology Immunity, Innate - immunology Immunologic Memory Immunology Infant, Newborn Infections Laboratory animals letter Living conditions Lymphocytes Male Medical treatment Mice Models, Animal multidisciplinary Neonates Pathogens Phenotype Physiological aspects Physiological research Rodents Science Specific Pathogen-Free Organisms T cells T-Lymphocytes - cytology T-Lymphocytes - immunology Tissue analysis Virus Diseases - immunology Virus Diseases - virology
ISSN:	0028-0836, 1476-4687, 1476-4687
Online-Zugang:	Volltext
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