Chemical Composition and Antioxidant, Analgesic, and Anti-Inflammatory Effects of Methanolic Extract of Euphorbia retusa in Mice

Plants provide an alternative source to manage different human disorders due to various metabolites. The aim of this study is to investigate the phytochemical constituents of the methanolic extracts of Euphorbia retusa and to evaluate their antioxidant, anti-inflammatory, and analgesic activities. T...

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Vydané v:Pain research & management Ročník 2018; číslo 2018; s. 1 - 11
Hlavní autori: Allagui, Mohamed Salah, Hfaiedh, Najla, Bouguerra, Wided, Ncib, Sana, Feriani, Anouar, Rjeibi, Ilhem, Sdayria, Jazia, Elfeki, Abdelfattah
Médium: Journal Article
Jazyk:English
Vydavateľské údaje: Cairo, Egypt Hindawi Publishing Corporation 01.01.2018
Hindawi
John Wiley & Sons, Inc
Wiley
Predmet:
Acetic acid
Acetic Acid - toxicity
Aluminum
Analgesics
Analgesics - chemistry
Analgesics - pharmacology
Analgesics - therapeutic use
Analysis
Animals
Anti-Inflammatory Agents - pharmacology
Anti-Inflammatory Agents - therapeutic use
Anti-inflammatory drugs
Antigens
Antimicrobial agents
Antioxidants
Antioxidants - chemistry
Antioxidants - pharmacology
Antioxidants - therapeutic use
Carrageenan - toxicity
Carrageenin
Catalase - metabolism
Disease Models, Animal
Dose-Response Relationship, Drug
Edema - drug therapy
Enzymes
Euphorbia - chemistry
Flavonoids
Free radicals
Herbal medicine
Histamine
Inflammation
Inflammation - chemically induced
Inflammation - drug therapy
Isoflavones
Lipid Peroxidation - drug effects
Medicine
Mice
Nitroblue Tetrazolium - metabolism
Nonsteroidal anti-inflammatory drugs
Organic acids
Pain Measurement
Phytochemicals
Plant Extracts - chemistry
Plant Extracts - pharmacology
Polyphenols
Rodents
Sodium
Statistical analysis
Superoxide Dismutase - metabolism
Thiazolidinediones - metabolism
Tumor necrosis factor-TNF
ISSN:1203-6765, 1918-1523, 1918-1523
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Shrnutí:Plants provide an alternative source to manage different human disorders due to various metabolites. The aim of this study is to investigate the phytochemical constituents of the methanolic extracts of Euphorbia retusa and to evaluate their antioxidant, anti-inflammatory, and analgesic activities. The phytochemical results obtained by HPLC and by chemical assay reactions have revealed the richness of the methanolic extract of E. retusa in active compounds, in particular polyphenols, flavonoids, and tannins. The methanolic extract shows significant antioxidant activities in vitro, in the DPPH and the FRAP assays. The antinociceptive activity was evaluated using acetic acid and hot-plate models of pain in mice. The anti-inflammatory activity was evaluated by carrageenan-induced paw edema. Oral pretreatment with the methanolic extract of E. retusa (200 mg/kg) exhibited a significant inhibition of pain induced either by acetic acid or by the heating plate and in a manner comparable to the standard drug paracetamol. E. retusa significantly reduced paw edema starting from the 3rd hour after carrageenan administration by increasing the activity of antioxidant enzymes (SOD, CAT, and GPx) in liver and paw tissues and decreasing the levels of MDA. These results may confirm the interesting potential of this plant as a treatment of various inflammatory and pain diseases.
Bibliografia:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
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Academic Editor: Shinya Kasai
ISSN:1203-6765
1918-1523
1918-1523
DOI:10.1155/2018/4838413