Evolutionary and phenotypic analysis of live virus isolates suggests arthropod origin of a pathogenic RNA virus family

The evolutionary origins of arboviruses are unknown because their typical dual host tropism is paraphyletic within viral families. Here we studied one of the most diversified and medically relevant RNA virus families, the Bunyaviridae, in which four of five established genera are transmitted by arth...

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Vydané v:	Proceedings of the National Academy of Sciences - PNAS Ročník 112; číslo 24; s. 7536 - 7541
Hlavní autori:	Marklewitz, Marco, Zirkel, Florian, Kurth, Andreas, Drosten, Christian, Junglen, Sandra
Médium:	Journal Article
Jazyk:	English
Vydavateľské údaje:	United States 16.06.2015
Predmet:	Amino Acid Sequence Animals Arboviruses - classification Arboviruses - genetics Arboviruses - pathogenicity Base Sequence Bunyaviridae - classification Bunyaviridae - genetics Bunyaviridae - pathogenicity Cell Line Conserved Sequence Culicidae - virology Endonucleases - genetics Evolution, Molecular Genome, Viral Host Specificity Microscopy, Electron Molecular Sequence Data Phenotype Phylogeny RNA Replicase - genetics RNA, Viral - genetics Sequence Homology, Amino Acid Species Specificity Temperature Viral Proteins - genetics ancestral reconstruction insect-specific virus bunyavirus virus evolution arbovirus
ISSN:	1091-6490
On-line prístup:	Zistit podrobnosti o prístupe
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