Quantifying selection in immune receptor repertoires

The efficient recognition of pathogens by the adaptive immune system relies on the diversity of receptors displayed at the surface of immune cells. T-cell receptor diversity results from an initial random DNA editing process, called VDJ recombination, followed by functional selection of cells accord...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS Jg. 111; H. 27; S. 9875
Hauptverfasser:	Elhanati, Yuval, Murugan, Anand, Callan, Jr, Curtis G, Mora, Thierry, Walczak, Aleksandra M
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	United States 08.07.2014
Schlagworte:	CD4-Positive T-Lymphocytes - immunology Humans Receptors, Antigen, T-Cell, alpha-beta - genetics Selection, Genetic public repertoire thymic selection statistical inference T cell
ISSN:	1091-6490, 1091-6490
Online-Zugang:	Weitere Angaben
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