Syncytia formation by SARS‐CoV‐2‐infected cells

Severe cases of COVID‐19 are associated with extensive lung damage and the presence of infected multinucleated syncytial pneumocytes. The viral and cellular mechanisms regulating the formation of these syncytia are not well understood. Here, we show that SARS‐CoV‐2‐infected cells express the Spike p...

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Bibliographic Details
Published in:	The EMBO journal Vol. 39; no. 23; pp. e106267 - n/a
Main Authors:	Buchrieser, Julian, Dufloo, Jérémy, Hubert, Mathieu, Monel, Blandine, Planas, Delphine, Rajah, Maaran Michael, Planchais, Cyril, Porrot, Françoise, Guivel‐Benhassine, Florence, Van der Werf, Sylvie, Casartelli, Nicoletta, Mouquet, Hugo, Bruel, Timothée, Schwartz, Olivier
Format:	Journal Article
Language:	English
Published:	London Nature Publishing Group UK 01.12.2020 Springer Nature B.V EMBO Press John Wiley and Sons Inc
Subjects:	ACE2 Angiotensin-Converting Enzyme 2 Angiotensin-Converting Enzyme 2 - genetics Angiotensin-Converting Enzyme 2 - metabolism Animals Antigens, Differentiation Antigens, Differentiation - genetics Antigens, Differentiation - metabolism Antiviral drugs Cell Fusion Cell Line Chlorocebus aethiops COVID-19 COVID-19 - metabolism COVID-19 - pathology COVID-19 - virology EMBO19 fusion Giant Cells Giant Cells - metabolism Giant Cells - virology HEK293 Cells Host-Pathogen Interactions Humans Infectivity Interferon Life Sciences Membrane Proteins Membrane Proteins - genetics Membrane Proteins - metabolism Microbiology and Parasitology Pathological effects Pneumocytes Protease Proteins RNA-Binding Proteins RNA-Binding Proteins - genetics RNA-Binding Proteins - metabolism SARS-CoV-2 Serine Serine Endopeptidases Serine Endopeptidases - genetics Serine Endopeptidases - metabolism Serine proteinase Severe acute respiratory syndrome Severe acute respiratory syndrome coronavirus 2 Spike Glycoprotein, Coronavirus Spike Glycoprotein, Coronavirus - metabolism Spike protein Syncytia Vero Cells Vero Cells - virology Viral diseases Virions Virology fusion syncytia interferon SARS‐CoV‐2 SARS-CoV-2
ISSN:	0261-4189, 1460-2075, 1460-2075
Online Access:	Get full text
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