Personalized Radiation Attenuating Materials for Gastrointestinal Mucosal Protection

Cancer patients undergoing therapeutic radiation routinely develop injury of the adjacent gastrointestinal (GI) tract mucosa due to treatment. To reduce radiation dose to critical GI structures including the rectum and oral mucosa, 3D‐printed GI radioprotective devices composed of high‐Z materials a...

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Vydáno v:	Advanced science Ročník 8; číslo 12; s. 2100510 - n/a
Hlavní autoři:	Byrne, James D., Young, Cameron C., Chu, Jacqueline N., Pursley, Jennifer, Chen, Mu Xian, Wentworth, Adam J., Feng, Annie, Kirtane, Ameya R., Remillard, Kyla A., Hancox, Cindy I., Bhagwat, Mandar S., Machado, Nicole, Hua, Tiffany, Tamang, Siddartha M., Collins, Joy E., Ishida, Keiko, Hayward, Alison, Becker, Sarah L., Edgington, Samantha K., Schoenfeld, Jonathan D., Jeck, William R., Hur, Chin, Traverso, Giovanni
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	Germany John Wiley & Sons, Inc 01.06.2021 John Wiley and Sons Inc Wiley
Témata:	3D printing Animals Cancer therapies Disease Models, Animal dosimetric analysis Erythema Esophagus Gastrointestinal Tract - diagnostic imaging Gastrointestinal Tract - radiation effects Humans Morbidity Mouth Neoplasms - radiotherapy Mucositis Mucous Membrane - diagnostic imaging Mucous Membrane - radiation effects Organs at Risk Printing, Three-Dimensional radiation attenuation Radiation Injuries - prevention & control radiation proctitis Radiation Protection - instrumentation Radiation Protection - methods Radiation therapy radiation‐induced mucositis radioprotective devices Rats Rats, Sprague-Dawley Rectum Swine Tomography, X-Ray Computed Tongue dosimetric analysis radiation proctitis radiation attenuation 3D printing radiation‐induced mucositis radioprotective devices
ISSN:	2198-3844, 2198-3844
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Popis
Shrnutí:	Cancer patients undergoing therapeutic radiation routinely develop injury of the adjacent gastrointestinal (GI) tract mucosa due to treatment. To reduce radiation dose to critical GI structures including the rectum and oral mucosa, 3D‐printed GI radioprotective devices composed of high‐Z materials are generated from patient CT scans. In a radiation proctitis rat model, a significant reduction in crypt injury is demonstrated with the device compared to without (p < 0.0087). Optimal device placement for radiation attenuation is further confirmed in a swine model. Dosimetric modeling in oral cavity cancer patients demonstrates a 30% radiation dose reduction to the normal buccal mucosa and a 15.2% dose reduction in the rectum for prostate cancer patients with the radioprotectant material in place compared to without. Finally, it is found that the rectal radioprotectant device is more cost‐effective compared to a hydrogel rectal spacer. Taken together, these data suggest that personalized radioprotectant devices may be used to reduce GI tissue injury in cancer patients undergoing therapeutic radiation. One of the most common side effects of radiation therapy is injury to the gastrointestinal (GI) tract. To reduce radiation‐induced injury, personalized 3D‐printed radioprotective devices made of high‐Z materials are developed that are shown to reduce radiation injury in two animal models, improve clinically significant dosimetry in at‐risk GI tissue in human cancer patients, and are more cost‐effective compared to standard‐of‐care therapy.
Bibliografie:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 content type line 23
ISSN:	2198-3844 2198-3844
DOI:	10.1002/advs.202100510