Personalized Radiation Attenuating Materials for Gastrointestinal Mucosal Protection

Cancer patients undergoing therapeutic radiation routinely develop injury of the adjacent gastrointestinal (GI) tract mucosa due to treatment. To reduce radiation dose to critical GI structures including the rectum and oral mucosa, 3D‐printed GI radioprotective devices composed of high‐Z materials a...

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Veröffentlicht in:Advanced science Jg. 8; H. 12; S. 2100510 - n/a
Hauptverfasser: Byrne, James D., Young, Cameron C., Chu, Jacqueline N., Pursley, Jennifer, Chen, Mu Xian, Wentworth, Adam J., Feng, Annie, Kirtane, Ameya R., Remillard, Kyla A., Hancox, Cindy I., Bhagwat, Mandar S., Machado, Nicole, Hua, Tiffany, Tamang, Siddartha M., Collins, Joy E., Ishida, Keiko, Hayward, Alison, Becker, Sarah L., Edgington, Samantha K., Schoenfeld, Jonathan D., Jeck, William R., Hur, Chin, Traverso, Giovanni
Format: Journal Article
Sprache:Englisch
Veröffentlicht: Germany John Wiley & Sons, Inc 01.06.2021
John Wiley and Sons Inc
Wiley
Schlagworte:
3D printing
Animals
Cancer therapies
Disease Models, Animal
dosimetric analysis
Erythema
Esophagus
Gastrointestinal Tract - diagnostic imaging
Gastrointestinal Tract - radiation effects
Humans
Morbidity
Mouth Neoplasms - radiotherapy
Mucositis
Mucous Membrane - diagnostic imaging
Mucous Membrane - radiation effects
Organs at Risk
Printing, Three-Dimensional
radiation attenuation
Radiation Injuries - prevention & control
radiation proctitis
Radiation Protection - instrumentation
Radiation Protection - methods
Radiation therapy
radiation‐induced mucositis
radioprotective devices
Rats
Rats, Sprague-Dawley
Rectum
Swine
Tomography, X-Ray Computed
Tongue
dosimetric analysis
radiation proctitis
radiation attenuation
3D printing
radiation‐induced mucositis
radioprotective devices
ISSN:2198-3844, 2198-3844
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Zusammenfassung:Cancer patients undergoing therapeutic radiation routinely develop injury of the adjacent gastrointestinal (GI) tract mucosa due to treatment. To reduce radiation dose to critical GI structures including the rectum and oral mucosa, 3D‐printed GI radioprotective devices composed of high‐Z materials are generated from patient CT scans. In a radiation proctitis rat model, a significant reduction in crypt injury is demonstrated with the device compared to without (p < 0.0087). Optimal device placement for radiation attenuation is further confirmed in a swine model. Dosimetric modeling in oral cavity cancer patients demonstrates a 30% radiation dose reduction to the normal buccal mucosa and a 15.2% dose reduction in the rectum for prostate cancer patients with the radioprotectant material in place compared to without. Finally, it is found that the rectal radioprotectant device is more cost‐effective compared to a hydrogel rectal spacer. Taken together, these data suggest that personalized radioprotectant devices may be used to reduce GI tissue injury in cancer patients undergoing therapeutic radiation. One of the most common side effects of radiation therapy is injury to the gastrointestinal (GI) tract. To reduce radiation‐induced injury, personalized 3D‐printed radioprotective devices made of high‐Z materials are developed that are shown to reduce radiation injury in two animal models, improve clinically significant dosimetry in at‐risk GI tissue in human cancer patients, and are more cost‐effective compared to standard‐of‐care therapy.
Bibliographie:ObjectType-Article-1
SourceType-Scholarly Journals-1
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ISSN:2198-3844
2198-3844
DOI:10.1002/advs.202100510