In silico and in vitro assessment of TP53, ATM, RAD51, and BAX genes in gastric cancer and their contribution to radiotherapy resistance

Background Gastric cancer remains a leading cause of cancer-related morbidity and mortality worldwide. The genetic factors contributing to gastric cancer progression and resistance to therapies, particularly radiotherapy, are not fully understood. TP53, ATM, RAD51, and BAX are genes involved in DNA...

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Bibliographic Details
Published in:	Hereditas Vol. 162; no. 1; p. 125
Main Authors:	Zhang, Junwei, He, Pengtao
Format:	Journal Article
Language:	English
Published:	London BioMed Central 12.07.2025 Nature Publishing Group BMC
Subjects:	Animal Genetics and Genomics Apoptosis Ataxia Telangiectasia Mutated Proteins - genetics bcl-2-Associated X Protein - genetics Biomedical and Life Sciences Cancer therapies Cell cycle Cell death Cell Line, Tumor Cell proliferation Chemotherapy computer simulation data collection Diagnostic biomarker disease diagnosis DNA damage DNA Methylation DNA repair Evolutionary Biology Gastric cancer Gene expression Gene Expression Regulation, Neoplastic Genetic factors Genomics Humans Life Sciences Medical prognosis meta-analysis methylation Morbidity mortality Mutation Mutation rates mutational analysis neoplasm cells neoplasm progression p53 Protein Protein expression protein synthesis Proteins Rad51 Recombinase - genetics Radiation therapy Radiation Tolerance - genetics radiotherapy Radiotherapy resistance stomach neoplasms Stomach Neoplasms - genetics Stomach Neoplasms - radiotherapy stress response Survival analysis Tumor cell lines Tumor Suppressor Protein p53 - genetics Tumors Wound healing Diagnostic biomarker Radiotherapy resistance Gene expression Gastric cancer
ISSN:	1601-5223, 0018-0661, 1601-5223
Online Access:	Get full text
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