Initiation and dose optimization for levodopa-carbidopa intestinal gel: Insights from phase 3 clinical trials

Levodopa-carbidopa intestinal gel (LCIG) provides continuous infusion and reduces “off” time in advanced Parkinson's disease (PD) patients with motor fluctuations despite optimized pharmacotherapy. Clinical experience with 2 LCIG dosing paradigms from phase 3 studies was examined. In an open-la...

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Bibliographic Details
Published in:	Parkinsonism & related disorders Vol. 21; no. 7; pp. 742 - 748
Main Authors:	Lew, Mark F., Slevin, John T., Krüger, Rejko, Martínez Castrillo, Juan Carlos, Chatamra, Krai, Dubow, Jordan S., Robieson, Weining Z., Benesh, Janet A., Fung, Victor S.C.
Format:	Journal Article
Language:	English
Published:	England Elsevier Ltd 01.07.2015
Subjects:	Antiparkinson Agents - administration & dosage Antiparkinson Agents - metabolism Carbidopa - administration & dosage Carbidopa - metabolism Dosing Double-Blind Method Drug Combinations Female Gels Humans Internationality Intestinal Absorption - drug effects Intubation, Gastrointestinal - methods Jejunum - drug effects Jejunum - metabolism Levodopa - administration & dosage Levodopa - metabolism Levodopa-carbidopa intestinal gel Male Motor fluctuations Neurology Parkinson's disease PEG-J procedure Motor fluctuations Dosing PEG-J procedure Levodopa-carbidopa intestinal gel Parkinson's disease
ISSN:	1353-8020, 1873-5126, 1873-5126
Online Access:	Get full text
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