Neuroglobin overexpression inhibits oxygen–glucose deprivation-induced mitochondrial permeability transition pore opening in primary cultured mouse cortical neurons

Neuroglobin (Ngb) is an endogenous neuroprotective molecule against hypoxic/ischemic brain injury, but the underlying mechanisms remain largely undefined. Our recent study revealed that Ngb can bind to voltage-dependent anion channel (VDAC), a regulator of mitochondria permeability transition (MPT)....

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Veröffentlicht in:	Neurobiology of disease Jg. 56; S. 95 - 103
Hauptverfasser:	Yu, Zhanyang, Liu, Ning, Li, Yadan, Xu, Jianfeng, Wang, Xiaoying
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	United States Elsevier Inc 01.08.2013 Elsevier
Schlagworte:	Animals Blotting, Western Cell Death - physiology Cerebral Cortex - cytology Cerebral Cortex - pathology Cyclosporine - pharmacology Cytochrome c Cytochromes c - metabolism Dependovirus - genetics Globins - biosynthesis Globins - physiology Glucose - deficiency Hypoxia - pathology Immunohistochemistry Immunoprecipitation L-Lactate Dehydrogenase - metabolism Mice Mitochondria - drug effects Mitochondria permeability transition pore (mPTP) Mitochondria swelling Mitochondrial Swelling - drug effects NAD - metabolism NAD+ release Nerve Tissue Proteins - biosynthesis Nerve Tissue Proteins - physiology Neuroglobin Neurology Neurons - drug effects Neurons - pathology Oxygen/glucose deprivation Permeability Primary Cell Culture Recombinant Proteins - metabolism RNA, Small Interfering - genetics Voltage-Dependent Anion Channels - metabolism Oxygen/glucose deprivation Cytochrome c NAD+ release Neuroglobin Mitochondria swelling Mitochondria permeability transition pore (mPTP) NAD + release
ISSN:	0969-9961, 1095-953X, 1095-953X
Online-Zugang:	Volltext
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