Volatile evolution of long noncoding RNA repertoires: mechanisms and biological implications

•lncRNAs show weak selective constraint, even when clearly functional.•Gain and loss of lncRNA genes occurs at very high pace during evolution.•lncRNAs mostly evolve de novo.•Bidirectional promoters and transposable elements (TEs) promote the birth of lncRNAs.•Genomes rich in TEs may have more compl...

Celý popis

Uloženo v:
Podrobná bibliografie
Vydáno v:Trends in genetics Ročník 30; číslo 10; s. 439 - 452
Hlavní autoři: Kapusta, Aurélie, Feschotte, Cédric
Médium: Journal Article
Jazyk:angličtina
Vydáno: England Elsevier Ltd 01.10.2014
Témata:
Animals
DNA Transposable Elements
Evolution, Molecular
Exons
Humans
Medical Education
Nucleic Acid Conformation
RNA, Long Noncoding - chemistry
RNA, Long Noncoding - metabolism
Transcription, Genetic
ISSN:0168-9525
On-line přístup:Získat plný text
Tagy: Přidat tag
Žádné tagy, Buďte první, kdo vytvoří štítek k tomuto záznamu!
Popis
Shrnutí:•lncRNAs show weak selective constraint, even when clearly functional.•Gain and loss of lncRNA genes occurs at very high pace during evolution.•lncRNAs mostly evolve de novo.•Bidirectional promoters and transposable elements (TEs) promote the birth of lncRNAs.•Genomes rich in TEs may have more complex and malleable transcriptomes. Thousands of genes encoding long noncoding RNAs (lncRNAs) have been identified in all vertebrate genomes thus far examined. The list of lncRNAs partaking in arguably important biochemical, cellular, and developmental activities is steadily growing. However, it is increasingly clear that lncRNA repertoires are subject to weak functional constraint and rapid turnover during vertebrate evolution. We discuss here some of the factors that may explain this apparent paradox, including relaxed constraint on sequence to maintain lncRNA structure/function, extensive redundancy in the regulatory circuits in which lncRNAs act, as well as adaptive and non-adaptive forces such as genetic drift. We explore the molecular mechanisms promoting the birth and rapid evolution of lncRNA genes, with an emphasis on the influence of bidirectional transcription and transposable elements, two pervasive features of vertebrate genomes. Together these properties reveal a remarkably dynamic and malleable noncoding transcriptome which may represent an important source of robustness and evolvability.
Bibliografie:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
ObjectType-Review-3
content type line 23
ISSN:0168-9525
DOI:10.1016/j.tig.2014.08.004