Interaction-based Mendelian randomization with measured and unmeasured gene-by-covariate interactions

Studies leveraging gene-environment (GxE) interactions within Mendelian randomization (MR) analyses have prompted the emergence of two similar methodologies: MR-GxE and MR-GENIUS. Such methods are attractive in allowing for pleiotropic bias to be corrected when using individual instruments. Specific...

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Veröffentlicht in:	PloS one Jg. 17; H. 8; S. e0271933
Hauptverfasser:	Spiller, Wes, Hartwig, Fernando Pires, Sanderson, Eleanor, Davey Smith, George, Bowden, Jack
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	United States Public Library of Science 10.08.2022 Public Library of Science (PLoS)
Schlagworte:	Alcohol use Analysis Bias Biology and Life Sciences Blood pressure Blood Pressure - genetics Body mass Body Mass Index Body size Causality Estimates Evaluation Exercise Genes Genome-Wide Association Study Medicine and Health Sciences Mendel's law Mendelian Randomization Analysis - methods Physical Sciences Randomization Research and Analysis Methods Sensitivity analysis United Kingdom
ISSN:	1932-6203, 1932-6203
Online-Zugang:	Volltext
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