Necrotic cells trigger a sterile inflammatory response through the Nlrp3 inflammasome

Dying cells are capable of activating the innate immune system and inducing a sterile inflammatory response. Here, we show that necrotic cells are sensed by the Nlrp3 inflammasome resulting in the subsequent release of the proinflammatory cytokine IL-1beta. Necrotic cells produced by pressure disrup...

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Bibliographic Details

Published in:	Proceedings of the National Academy of Sciences - PNAS Vol. 106; no. 48; p. 20388
Main Authors:	Iyer, Shankar S, Pulskens, Wilco P, Sadler, Jeffrey J, Butter, Loes M, Teske, Gwendoline J, Ulland, Tyler K, Eisenbarth, Stephanie C, Florquin, Sandrine, Flavell, Richard A, Leemans, Jaklien C, Sutterwala, Fayyaz S
Format:	Journal Article
Language:	English
Published:	United States 01.12.2009
Subjects:	Adenosine Triphosphate - metabolism Animals Carrier Proteins - immunology Carrier Proteins - metabolism Enzyme-Linked Immunosorbent Assay Extracellular Matrix Proteins - metabolism Inflammation - immunology Interleukin-1beta - immunology Mice Mice, Inbred C57BL Mitochondria - metabolism Necrosis - immunology NLR Family, Pyrin Domain-Containing 3 Protein
ISSN:	1091-6490, 1091-6490
Online Access:	Get more information
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