Homology-independent discovery of replicating pathogenic circular RNAs by deep sequencing and a new computational algorithm

A common challenge in pathogen discovery by deep sequencing approaches is to recognize viral or subviral pathogens in samples of diseased tissue that share no significant homology with a known pathogen. Here we report a homology-independent approach for discovering viroids, a distinct class of free...

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Bibliographic Details

Published in:	Proceedings of the National Academy of Sciences - PNAS Vol. 109; no. 10; p. 3938
Main Authors:	Wu, Qingfa, Wang, Ying, Cao, Mengji, Pantaleo, Vitantonio, Burgyan, Joszef, Li, Wan-Xiang, Ding, Shou-Wei
Format:	Journal Article
Language:	English
Published:	United States 06.03.2012
Subjects:	Algorithms Computational Biology - methods High-Throughput Nucleotide Sequencing - methods Models, Genetic Nucleic Acid Conformation Plant Diseases - virology RNA - genetics RNA, Catalytic - chemistry RNA, Catalytic - genetics RNA, Viral - genetics Software Viroids - chemistry Virus Replication Vitis - virology
ISSN:	1091-6490, 1091-6490
Online Access:	Get more information
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