Caveolin-1(-/-)- and caveolin-2(-/-)-deficient mice both display numerous skeletal muscle abnormalities, with tubular aggregate formation

Here, we examine the role of "non-muscle" caveolins (Cav-1 and Cav-2) in skeletal muscle biology. Our results indicate that skeletal muscle fibers from male Cav-1(-/-) and Cav-2(-/-) mice show striking abnormalities, such as tubular aggregates, mitochondrial proliferation/aggregation, and...

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Veröffentlicht in:	The American journal of pathology Jg. 170; H. 1; S. 316
Hauptverfasser:	Schubert, William, Sotgia, Federica, Cohen, Alex W, Capozza, Franco, Bonuccelli, Gloria, Bruno, Claudio, Minetti, Carlo, Bonilla, Eduardo, Dimauro, Salvatore, Lisanti, Michael P
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	United States 01.01.2007
Schlagworte:	Animals Cadherins - biosynthesis Caveolin 1 - deficiency Caveolin 1 - genetics Caveolin 2 - deficiency Caveolin 2 - genetics Disease Models, Animal Electron Transport Complex IV - analysis Genetic Predisposition to Disease Male Mice Mice, Knockout Microscopy, Electron, Transmission Mitochondria, Muscle - metabolism Mitochondria, Muscle - ultrastructure Muscle Fibers, Skeletal - metabolism Muscle Fibers, Skeletal - ultrastructure Muscle, Skeletal - abnormalities Muscle, Skeletal - metabolism Muscle, Skeletal - ultrastructure Muscular Diseases - genetics Muscular Diseases - metabolism Muscular Diseases - pathology Myoblasts - metabolism Myoblasts - pathology
ISSN:	0002-9440
Online-Zugang:	Weitere Angaben
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