The genomics of oxidative DNA damage, repair, and resulting mutagenesis

[Display omitted] Reactive oxygen species are a constant threat to DNA as they modify bases with the risk of disrupting genome function, inducing genome instability and mutation. Such risks are due to primary oxidative DNA damage and also mediated by the repair process. This leads to a delicate deci...

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Veröffentlicht in:	Computational and structural biotechnology journal Jg. 18; S. 207 - 219
1. Verfasser:	Poetsch, Anna R.
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	Netherlands Elsevier B.V 01.01.2020 Research Network of Computational and Structural Biotechnology Elsevier
Schlagworte:	8-oxo-7,8-dihydroguanine 8-oxoG AP site BER Cancer DNA DNA damage Epigenetics genes genetic instability Genomics inflammation Mutagenesis mutagens neoplasms nucleotide sequences Oxidative stress reactive oxygen species Review risk ROS Oxidative stress 8-oxo-7,8-dihydroguanine Mutagenesis Genomics DNA damage ROS Epigenetics AP site 8-oxoG BER Cancer
ISSN:	2001-0370, 2001-0370
Online-Zugang:	Volltext
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