New insights into the genetic etiology of Alzheimer’s disease and related dementias

Characterization of the genetic landscape of Alzheimer’s disease (AD) and related dementias (ADD) provides a unique opportunity for a better understanding of the associated pathophysiological processes. We performed a two-stage genome-wide association study totaling 111,326 clinically diagnosed/‘pro...

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Bibliographic Details
Published in:	Nature genetics Vol. 54; no. 4; pp. 412 - 436
Main Authors:	Holmans, Peter A., de Rojas, Itziar, Bis, Joshua C., Alarcón-Martín, Emilio, Alcolea, Daniel, Alegret, Montserrat, Alvarez, Ignacio, Álvarez, Victoria, Antúnez, Carmen, Arosio, Beatrice, Athanasiu, Lavinia, Banaj, Nerisa, Below, Jennifer E., Benussi, Luisa, Bossù, Paola, Burholt, Vanessa, Calero, Miguel, Cervera-Carles, Laura, Chen, Hung-Hsin, Custodero, Carlo, de Paiva Lopes, Katia, DeStefano, Anita, Dichgans, Martin, Diehl-Schmid, Janine, Duron, Emmanuelle, Dufouil, Carole, Espinosa, Ana, Nielsen, Sune Fallgaard, Fenoglio, Chiara, Ferrari, Raffaele, Fox, Nick C., Frank-García, Ana, Galimberti, Daniela, Grande, Giulia, Green, Emma, Grünblatt, Edna, Grunin, Michelle, Gudnason, Vilmundur, Hampel, Harald, Hausner, Lucrezia, Hulsman, Marc, Kivipelto, Miia, Kornhuber, Johannes, Kuzma, Amanda B., Launer, Lenore, Ma, Yiyi, Maier, Wolfgang, Montes, Angel Martín, Masullo, Carlo, Mendoza, Silvia, Moebus, Susanne, Morgan, Kevin, Muchnik, Carolina, Mukherjee, Shubhabrata, Nacmias, Benedetta, Ngandu, Tiia, Nicolas, Gael, Nordestgaard, Børge G., Ortega, Gemma, Paolo, Caffarra, Papenberg, Goran, Peloso, Gina, Pérez-Cordón, Alba, Pérez-Tur, Jordi, Pineda, Juan A., Pisanu, Claudia, Polak, Thomas, Quintela, Inés, Rábano, Alberto, Reinders, Marcel J. T., Riedel-Heller, Steffi, Rubino, Elisa, Rujescu, Dan, Sanabria, Ángela, Sánchez-Valle, Raquel, Satizabal, Claudia L., Scarpini, Elio, Scheltens, Philip, Schmid, Matthias, Schneider, Anja, Serrano, Manuel, Solomon, Alina, Song, Yeunjoo, Spalletta, Gianfranco, Squassina, Alessio, Stordal, Eystein, Tartan, Juan Pablo, Tárraga, Lluís, Thomas, Tegos, Tosto, Giuseppe, Wallon, David, Wang, Li-San, Weinhold, Leonie, Wiltfang, Jens, Zare, Habil, Farrer, Lindsay A., Psaty, Bruce M., Williams, Julie, Frikke-Schmidt, Ruth, Deleuze, Jean-François
Format:	Journal Article
Language:	English
Published:	New York Nature Publishing Group US 01.04.2022 Nature Publishing Group
Subjects:	45/43 631/208/205/2138 692/699/375/365/1283 Age factors Agriculture Alzheimer Disease - genetics Alzheimer Disease - pathology Alzheimer's disease Amyloid Amyotrophic lateral sclerosis Animal Genetics and Genomics Apolipoprotein E Biobanks Biomedical and Life Sciences Biomedicine Brain Cancer Research Cognitive ability Cognitive Dysfunction - psychology Consortia Dementia Dementia disorders Etiology Gene expression Gene Function Genome-wide association studies Genome-Wide Association Study Genomes Genomics Health risk assessment Human Genetics Humans Life Sciences Loci Meta-analysis Microglia Neurodegenerative diseases Parkinson's disease Proteins Risk management Santé publique et épidémiologie Tau protein tau Proteins - genetics Tumor necrosis factor-α Ubiquitin
ISSN:	1061-4036, 1546-1718, 1546-1718
Online Access:	Get full text
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