Distinct metabolism of apolipoproteins (a) and B-100 within plasma lipoprotein(a)

Lipoprotein(a) [Lp(a)] is mainly similar in composition to LDL, but differs in having apolipoprotein (apo) (a) covalently linked to apoB-100. Our purpose was to examine the individual metabolism of apo(a) and apoB-100 within plasma Lp(a). The kinetics of apo(a) and apoB-100 in plasma Lp(a) were asse...

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Veröffentlicht in:	Metabolism, clinical and experimental Jg. 65; H. 4; S. 381 - 390
Hauptverfasser:	Diffenderfer, Margaret R., Lamon-Fava, Stefania, Marcovina, Santica M., Barrett, P. Hugh R., Lel, Julian, Dolnikowski, Gregory G., Berglund, Lars, Schaefer, Ernst J.
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	United States Elsevier Inc 01.04.2016
Schlagworte:	Apolipoprotein B-100 - biosynthesis Apolipoprotein B-100 - blood Apolipoprotein B-100 - metabolism Apolipoproteins A - biosynthesis Apolipoproteins A - metabolism Dyslipidemias - blood Endocrinology & Metabolism Fed state Humans Hypertriglyceridemia Hypertriglyceridemia - metabolism Kinetics Leucine - metabolism Lipids - blood Lipoprotein(a) Lipoprotein(a) - biosynthesis Lipoprotein(a) - metabolism Male Middle Aged apo PR PAS PS d PCSK9 Lp(a) TC IDL Lipoprotein(a) TG FCR Fed state Hypertriglyceridemia VLDL KIV2 KIV1 Kinetics CHD GC/MS apolipoprotein gas chromatography/mass spectrometry intermediate density lipoprotein ( d 1.006–1.019 g/mL) KIV 2 KIV 1 total cholesterol fractional catabolic rate periodic acid Schiff's base kringle IV 2 kringle IV 1 proprotein convertase subtilisin/kexin type 9 density production rate triglycerides pool size coronary heart disease very low-density lipoprotein ( d < 1.006 g/mL) lipoprotein(a)
ISSN:	0026-0495, 1532-8600, 1532-8600
Online-Zugang:	Volltext
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