Multiple loci influence erythrocyte phenotypes in the CHARGE Consortium

Santhi Ganesh and colleagues report meta-analyses of genome-wide association studies of six erythrocyte traits within the CHARGE consortium, with replication in cohorts of the HaemGen consortium. They report 23 loci associated with a range of clinically relevant red blood cell traits. Measurements o...

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Bibliographic Details
Published in:	Nature genetics Vol. 41; no. 11; pp. 1191 - 1198
Main Authors:	Ganesh, Santhi K, Zakai, Neil A, van Rooij, Frank J A, Soranzo, Nicole, Smith, Albert V, Nalls, Michael A, Chen, Ming-Huei, Kottgen, Anna, Glazer, Nicole L, Dehghan, Abbas, Kuhnel, Brigitte, Aspelund, Thor, Yang, Qiong, Tanaka, Toshiko, Jaffe, Andrew, Bis, Joshua C M, Verwoert, Germaine C, Teumer, Alexander, Fox, Caroline S, Guralnik, Jack M, Ehret, Georg B, Rice, Kenneth, Felix, Janine F, Rendon, Augusto, Eiriksdottir, Gudny, Levy, Daniel, Patel, Kushang V, Boerwinkle, Eric, Rotter, Jerome I, Hofman, Albert, Sambrook, Jennifer G, Hernandez, Dena G, Zheng, Gang, Bandinelli, Stefania, Singleton, Andrew B, Coresh, Josef, Lumley, Thomas, Uitterlinden, André G, vanGils, Janine M, Launer, Lenore J, Cupples, L Adrienne, Oostra, Ben A, Zwaginga, Jaap-Jan, Ouwehand, Willem H, Thein, Swee-Lay, Meisinger, Christa, Deloukas, Panos, Nauck, Matthias, Spector, Tim D, Gieger, Christian, Gudnason, Vilmundur, van Duijn, Cornelia M, Psaty, Bruce M, Ferrucci, Luigi, Chakravarti, Aravinda, Greinacher, Andreas, O'Donnell, Christopher J, Witteman, Jacqueline C M, Furth, Susan, Cushman, Mary, Harris, Tamara B, Lin, Jing-Ping
Format:	Journal Article
Language:	English
Published:	New York Nature Publishing Group US 01.11.2009 Nature Publishing Group
Subjects:	Agriculture Animal Genetics and Genomics Biological and medical sciences Biomedical and Life Sciences Biomedicine Blood diseases Blood pressure Blood Pressure - genetics Cancer Research Cell Line Clinical medicine Cohort Studies Data analysis Endothelial Cells - metabolism Erythrocytes Erythrocytes - metabolism Fundamental and applied biological sciences. Psychology Gene Expression Gene Function Genetic aspects Genetic disorders Genetics of eukaryotes. Biological and molecular evolution Genome, Human Genome-Wide Association Study Genotype & phenotype Hemoglobin Human Genetics Humans Hypertension - genetics Inflation Meta-analysis Phenotype Physiological aspects Polymorphism, Single Nucleotide Quantitative Trait Loci Sample size United States United Kingdom Netherlands Locus Phenotype
ISSN:	1061-4036, 1546-1718, 1546-1718
Online Access:	Get full text
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