Preventing Alzheimer's disease-related gray matter atrophy by B-vitamin treatment

Is it possible to prevent atrophy of key brain regions related to cognitive decline and Alzheimer's disease (AD)? One approach is to modify nongenetic risk factors, for instance by lowering elevated plasma homocysteine using B vitamins. In an initial, randomized controlled study on elderly subj...

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Bibliographic Details
Published in:	Proceedings of the National Academy of Sciences - PNAS Vol. 110; no. 23; p. 9523
Main Authors:	Douaud, Gwenaëlle, Refsum, Helga, de Jager, Celeste A, Jacoby, Robin, Nichols, Thomas E, Smith, Stephen M, Smith, A David
Format:	Journal Article
Language:	English
Published:	United States 04.06.2013
Subjects:	Alzheimer Disease - complications Bayes Theorem England Hippocampus - drug effects Hippocampus - pathology Homocysteine - blood Humans Image Processing, Computer-Assisted Linear Models Longitudinal Studies Magnetic Resonance Imaging Nerve Degeneration - etiology Nerve Degeneration - pathology Nerve Degeneration - prevention & control Temporal Lobe - drug effects Temporal Lobe - pathology Vitamin B Complex - pharmacology Vitamin B Complex - therapeutic use England clinical trial structural neuroimaging hippocampus causal modeling degeneration
ISSN:	1091-6490, 1091-6490
Online Access:	Get more information
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