Hypothesis: Sarcoidosis is a STAT1-mediated disease

Immunologic pathways involved in sarcoidosis pathogenesis are largely unknown. We hypothesized that patients with sarcoidosis have characteristic mRNA profiles. Microarray analysis of gene expression was done on peripheral blood (12 patients, 12 controls), lung (6 patients, 6 controls) and lymph nod...

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Bibliographic Details
Published in:	Clinical immunology (Orlando, Fla.) Vol. 132; no. 2; pp. 174 - 183
Main Authors:	Rosenbaum, James T., Pasadhika, Sirichai, Crouser, Elliott D., Choi, Dongseok, Harrington, Christina A., Lewis, Jinnell A., Austin, Carrie R., Diebel, Tessa N., Vance, Emily E., Braziel, Rita M., Smith, Justine R., Planck, Stephen R.
Format:	Journal Article
Language:	English
Published:	Amsterdam Elsevier Inc 01.08.2009 Elsevier
Subjects:	Adult Aged Allergy and Immunology Biological and medical sciences Down-Regulation Female Fundamental and applied biological sciences. Psychology Fundamental immunology Gene Expression Profiling Gene Regulatory Networks Genetic Predisposition to Disease - genetics Humans Lung - metabolism Lymph Nodes - metabolism Male Medical sciences Microarray analysis Middle Aged Models, Genetic Oligonucleotide Array Sequence Analysis - methods Ophthalmology Phosphoproteins - genetics Receptors, Interferon - genetics Sarcoidosis Sarcoidosis - genetics Sarcoidosis. Granulomatous diseases of unproved etiology. Connective tissue diseases. Elastic tissue diseases. Vasculitis STAT1 Transcription Factor - genetics Up-Regulation Uvea diseases Uveitis Young Adult Sarcoidosis Gene expression profiling Uveitis Microarray analysis Transcription factor STAT1 Eye disease Immunology Systemic disease Uvea disease Hypothesis Gene expression profile
ISSN:	1521-6616, 1521-7035, 1521-7035
Online Access:	Get full text
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