FHIRChain: Applying Blockchain to Securely and Scalably Share Clinical Data

Secure and scalable data sharing is essential for collaborative clinical decision making. Conventional clinical data efforts are often siloed, however, which creates barriers to efficient information exchange and impedes effective treatment decision made for patients. This paper provides four contri...

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Published in:Computational and structural biotechnology journal Vol. 16; pp. 267 - 278
Main Authors: Zhang, Peng, White, Jules, Schmidt, Douglas C., Lenz, Gunther, Rosenbloom, S. Trent
Format: Journal Article
Language:English
Published: Netherlands Elsevier B.V 01.01.2018
Research Network of Computational and Structural Biotechnology
Elsevier
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ISSN:2001-0370, 2001-0370
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Abstract Secure and scalable data sharing is essential for collaborative clinical decision making. Conventional clinical data efforts are often siloed, however, which creates barriers to efficient information exchange and impedes effective treatment decision made for patients. This paper provides four contributions to the study of applying blockchain technology to clinical data sharing in the context of technical requirements defined in the “Shared Nationwide Interoperability Roadmap” from the Office of the National Coordinator for Health Information Technology (ONC). First, we analyze the ONC requirements and their implications for blockchain-based systems. Second, we present FHIRChain, which is a blockchain-based architecture designed to meet ONC requirements by encapsulating the HL7 Fast Healthcare Interoperability Resources (FHIR) standard for shared clinical data. Third, we demonstrate a FHIRChain-based decentralized app using digital health identities to authenticate participants in a case study of collaborative decision making for remote cancer care. Fourth, we highlight key lessons learned from our case study.
AbstractList Secure and scalable data sharing is essential for collaborative clinical decision making. Conventional clinical data efforts are often siloed, however, which creates barriers to efficient information exchange and impedes effective treatment decision made for patients. This paper provides four contributions to the study of applying blockchain technology to clinical data sharing in the context of technical requirements defined in the “Shared Nationwide Interoperability Roadmap” from the Office of the National Coordinator for Health Information Technology (ONC). First, we analyze the ONC requirements and their implications for blockchain-based systems. Second, we present FHIRChain, which is a blockchain-based architecture designed to meet ONC requirements by encapsulating the HL7 Fast Healthcare Interoperability Resources (FHIR) standard for shared clinical data. Third, we demonstrate a FHIRChain-based decentralized app using digital health identities to authenticate participants in a case study of collaborative decision making for remote cancer care. Fourth, we highlight key lessons learned from our case study. Keywords: Blockchain, Smart contracts, Decentralized app, Interoperability, Digital health identity, Clinical data sharing, Cancer care
Secure and scalable data sharing is essential for collaborative clinical decision making. Conventional clinical data efforts are often siloed, however, which creates barriers to efficient information exchange and impedes effective treatment decision made for patients. This paper provides four contributions to the study of applying blockchain technology to clinical data sharing in the context of technical requirements defined in the “Shared Nationwide Interoperability Roadmap” from the Office of the National Coordinator for Health Information Technology (ONC). First, we analyze the ONC requirements and their implications for blockchain-based systems. Second, we present FHIRChain, which is a blockchain-based architecture designed to meet ONC requirements by encapsulating the HL7 Fast Healthcare Interoperability Resources (FHIR) standard for shared clinical data. Third, we demonstrate a FHIRChain-based decentralized app using digital health identities to authenticate participants in a case study of collaborative decision making for remote cancer care. Fourth, we highlight key lessons learned from our case study.
Secure and scalable data sharing is essential for collaborative clinical decision making. Conventional clinical data efforts are often siloed, however, which creates barriers to efficient information exchange and impedes effective treatment decision made for patients. This paper provides four contributions to the study of applying blockchain technology to clinical data sharing in the context of technical requirements defined in the "Shared Nationwide Interoperability Roadmap" from the Office of the National Coordinator for Health Information Technology (ONC). First, we analyze the ONC requirements and their implications for blockchain-based systems. Second, we present FHIRChain, which is a blockchain-based architecture designed to meet ONC requirements by encapsulating the HL7 Fast Healthcare Interoperability Resources (FHIR) standard for shared clinical data. Third, we demonstrate a FHIRChain-based decentralized app using digital health identities to authenticate participants in a case study of collaborative decision making for remote cancer care. Fourth, we highlight key lessons learned from our case study.Secure and scalable data sharing is essential for collaborative clinical decision making. Conventional clinical data efforts are often siloed, however, which creates barriers to efficient information exchange and impedes effective treatment decision made for patients. This paper provides four contributions to the study of applying blockchain technology to clinical data sharing in the context of technical requirements defined in the "Shared Nationwide Interoperability Roadmap" from the Office of the National Coordinator for Health Information Technology (ONC). First, we analyze the ONC requirements and their implications for blockchain-based systems. Second, we present FHIRChain, which is a blockchain-based architecture designed to meet ONC requirements by encapsulating the HL7 Fast Healthcare Interoperability Resources (FHIR) standard for shared clinical data. Third, we demonstrate a FHIRChain-based decentralized app using digital health identities to authenticate participants in a case study of collaborative decision making for remote cancer care. Fourth, we highlight key lessons learned from our case study.
Secure and scalable data sharing is essential for collaborative clinical decision making. Conventional clinical data efforts are often siloed, however, which creates barriers to efficient information exchange and impedes effective treatment decision made for patients. This paper provides four contributions to the study of applying blockchain technology to clinical data sharing in the context of technical requirements defined in the "Shared Nationwide Interoperability Roadmap" from the (ONC). First, we analyze the ONC requirements and their implications for blockchain-based systems. Second, we present FHIRChain, which is a blockchain-based architecture designed to meet ONC requirements by encapsulating the HL7 (FHIR) standard for shared clinical data. Third, we demonstrate a FHIRChain-based decentralized app using digital health identities to authenticate participants in a case study of collaborative decision making for remote cancer care. Fourth, we highlight key lessons learned from our case study.
Author Zhang, Peng
White, Jules
Rosenbloom, S. Trent
Schmidt, Douglas C.
Lenz, Gunther
AuthorAffiliation c Department of Biomedical Informatics, Vanderbilt University Medical Center, Nashville, TN, USA
a Department of Electrical Engineering and Computer Science, Vanderbilt University, Nashville, TN, USA
b Varian Medical Systems, Palo Alto, California, USA
AuthorAffiliation_xml – name: b Varian Medical Systems, Palo Alto, California, USA
– name: a Department of Electrical Engineering and Computer Science, Vanderbilt University, Nashville, TN, USA
– name: c Department of Biomedical Informatics, Vanderbilt University Medical Center, Nashville, TN, USA
Author_xml – sequence: 1
  givenname: Peng
  surname: Zhang
  fullname: Zhang, Peng
  email: peng.zhang@vanderbilt.edu
  organization: Department of Electrical Engineering and Computer Science, Vanderbilt University, Nashville, TN, USA
– sequence: 2
  givenname: Jules
  surname: White
  fullname: White, Jules
  email: jules.white@vanderbilt.edu
  organization: Department of Electrical Engineering and Computer Science, Vanderbilt University, Nashville, TN, USA
– sequence: 3
  givenname: Douglas C.
  surname: Schmidt
  fullname: Schmidt, Douglas C.
  email: d.schmidt@vanderbilt.edu
  organization: Department of Electrical Engineering and Computer Science, Vanderbilt University, Nashville, TN, USA
– sequence: 4
  givenname: Gunther
  surname: Lenz
  fullname: Lenz, Gunther
  email: gunther.lenz@varian.com
  organization: Varian Medical Systems, Palo Alto, California, USA
– sequence: 5
  givenname: S. Trent
  surname: Rosenbloom
  fullname: Rosenbloom, S. Trent
  email: trent.rosenbloom@vanderbilt.edu
  organization: Department of Biomedical Informatics, Vanderbilt University Medical Center, Nashville, TN, USA
BackLink https://www.ncbi.nlm.nih.gov/pubmed/30108685$$D View this record in MEDLINE/PubMed
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Cites_doi 10.1007/s10916-016-0574-6
10.1136/amiajnl-2012-000887
10.7326/M15-2928
10.1002/hec.952
10.1001/archinte.163.12.1409
10.1145/2754951
10.1001/archinternmed.2009.333
10.1145/383845.383856
10.1093/jamia/ocx068
10.1200/JOP.091067
10.1186/s12916-015-0525-y
10.1016/j.giq.2009.12.013
10.1197/jamia.M2470
10.1089/tmj.2013.0320
10.1001/jamainternmed.2013.2777
10.1197/jamia.M1888
10.1056/NEJMp1607282
10.1136/amiajnl-2013-002117
10.1186/s13336-015-0019-3
10.1016/S0959-8049(00)00057-5
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Keywords Digital health identity
Clinical data sharing
Smart contracts
Blockchain
Cancer care
Interoperability
Decentralized app
Language English
License This is an open access article under the CC BY license.
This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
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References Yue, Wang, Jin, Li, Jiang (bb0220) 2016; 40
Greenspan (bb0200) 2018
Introduction to the ISA (bb0235)
Taichman, Backus, Baethge, Bauchner, De Leeuw, Drazen (bb0030) 2016; 164
Johnston, Yilmaz, Kandah, Bentenitis, Hashemi, Gross (bb0150) 2014
Shea (bb0225) 2018
Ricke, Bartelink (bb0050) 2000; 36
Maheu, Whitten, Allen (bb0085) 2002
Richesson, Krischer (bb0105) 2007; 14
Krawczyk (bb0260) 2001
Warren (bb0035) 2016; 375
Peterson, Deeduvanu, Kanjamala, Boles (bb0180) 2016
Amazon Web Services (bb0315) 2018
Zhang, Walker, White, Schmidt, Lenz (bb0130) 2017
Hardt (bb0230) 2012
I. G. B. S. P. S. Team (bb0165) 2016
Levit, Smith, Benz, Ferrell (bb0060) 2010; 6
Larose, Strover, Gregg, Straubhaar (bb0090) 2011; 28
Zhang, White, Schmidt, Lenz (bb0135) 2017
Leff, Rayfield (bb0250) 2001
Terry (bb0065) 2009; 15
Desalvo, Galvez (bb0140) 2015
C. for Disease Control, Prevention (bb0205) 2003; vol. 52
Dolin, Alschuler, Boyer, Beebe, Behlen, Biron (bb0285) 2006; 13
Das (bb0110) 2017
Crockford (bb0265) 2006
Kim Futrell (bb0240) 2013
Peter, Nichol (bb0160) 2016
Hripcsak, Bloomrosen, Flatelybrennan, Chute, Cimino, Detmer (bb0075) 2014; 21
Ylonen, Lonvick (bb0255) 2006
Downey, Olson (bb0070) 2013
Gross (bb0045) 1987; 37
Ekblaw, Azaria, Halamka, Lippman (bb0175) 2018
Kuo, Kim, Ohno-Machado (bb0170) 2017; 24
Mettler (bb0115) 2016
Hartvigsen, Johansen, Hasvold, Bellika, Arsand, Arild (bb0080) 2007; 129
Bender, Sartipi (bb0100) 2013
Hapi-fhir (bb0270)
Greenspan (bb0300) 2015
Gropper (bb0190) 2016
Geifman, Bollyky, Bhattacharya, Butte (bb0040) 2015; 13
Greenspan (bb0295) 2018
Nakamoto (bb0125) 2008
HealthIT.gov (bb0195)
Alvarez, Hall, Trechsel (bb0280) 2009; 42
Menezes, Van Oorschot, Vanstone (bb0210) 1996
Bondi (bb0095) 2018
Al Omar, Rahman, Basu, Kiyomoto (bb0215) 2018
Singh, Giardina, Meyer, Forjuoh, Reis, Thomas (bb0015) 2013; 173
Castaneda, Nalley, Mannion, Bhattacharyya, Blake, Pecora (bb0010) 2015; 5
Azaria, Ekblaw, Vieira, Lippman (bb0120) 2018
Anthes (bb0310) 2015; 58
Dubovitskaya, Xu, Ryu, Schumacher, Wang (bb0185) 2017
Berman, Fenaughty (bb0005) 2005; 14
Krawiec, Housman, White, Filipova, Quarre, Barr (bb0155) 2018
Kaushal, Shojania, Bates (bb0020) 2003; 163
Even, Goldreich, Yacobi (bb0305) 2018
Schiff, Hasan, Kim, Abrams, Cosby, Lambert (bb0025) 2009; 169
Ossher, Tarr (bb0275) 2001; 44
Rackoff, Simon (bb0290) 2018
Marshall, Petersen, Naik, Velde, Artinyan, Albo (bb0055) 2014; 20
Buterin (bb0145) 2013
Kawamoto, Hongsermeier, Wright, Lewis, Bell, Middleton (bb0245) 2013; 20
Greenspan (10.1016/j.csbj.2018.07.004_bb0295)
Ylonen (10.1016/j.csbj.2018.07.004_bb0255) 2006
Ossher (10.1016/j.csbj.2018.07.004_bb0275) 2001; 44
Singh (10.1016/j.csbj.2018.07.004_bb0015) 2013; 173
Peter (10.1016/j.csbj.2018.07.004_bb0160) 2016
Geifman (10.1016/j.csbj.2018.07.004_bb0040) 2015; 13
Hripcsak (10.1016/j.csbj.2018.07.004_bb0075) 2014; 21
Downey (10.1016/j.csbj.2018.07.004_bb0070) 2013
Mettler (10.1016/j.csbj.2018.07.004_bb0115) 2016
Marshall (10.1016/j.csbj.2018.07.004_bb0055) 2014; 20
Zhang (10.1016/j.csbj.2018.07.004_bb0135) 2017
Nakamoto (10.1016/j.csbj.2018.07.004_bb0125) 2008
HealthIT.gov (10.1016/j.csbj.2018.07.004_bb0195)
Levit (10.1016/j.csbj.2018.07.004_bb0060) 2010; 6
Even (10.1016/j.csbj.2018.07.004_bb0305) 2018
Greenspan (10.1016/j.csbj.2018.07.004_bb0200)
Warren (10.1016/j.csbj.2018.07.004_bb0035) 2016; 375
Richesson (10.1016/j.csbj.2018.07.004_bb0105) 2007; 14
Dubovitskaya (10.1016/j.csbj.2018.07.004_bb0185) 2017
Ekblaw (10.1016/j.csbj.2018.07.004_bb0175) 2018
Introduction to the ISA (10.1016/j.csbj.2018.07.004_bb0235)
Hapi-fhir (10.1016/j.csbj.2018.07.004_bb0270)
Desalvo (10.1016/j.csbj.2018.07.004_bb0140) 2015
Terry (10.1016/j.csbj.2018.07.004_bb0065) 2009; 15
Castaneda (10.1016/j.csbj.2018.07.004_bb0010) 2015; 5
Hardt (10.1016/j.csbj.2018.07.004_bb0230) 2012
Greenspan (10.1016/j.csbj.2018.07.004_bb0300)
Krawczyk (10.1016/j.csbj.2018.07.004_bb0260) 2001
Das (10.1016/j.csbj.2018.07.004_bb0110) 2017
Kawamoto (10.1016/j.csbj.2018.07.004_bb0245) 2013; 20
Schiff (10.1016/j.csbj.2018.07.004_bb0025) 2009; 169
Hartvigsen (10.1016/j.csbj.2018.07.004_bb0080) 2007; 129
Kaushal (10.1016/j.csbj.2018.07.004_bb0020) 2003; 163
Kuo (10.1016/j.csbj.2018.07.004_bb0170) 2017; 24
Bender (10.1016/j.csbj.2018.07.004_bb0100) 2013
Menezes (10.1016/j.csbj.2018.07.004_bb0210) 1996
Azaria (10.1016/j.csbj.2018.07.004_bb0120) 2018
Shea (10.1016/j.csbj.2018.07.004_bb0225)
Gropper (10.1016/j.csbj.2018.07.004_bb0190) 2016
Alvarez (10.1016/j.csbj.2018.07.004_bb0280) 2009; 42
Maheu (10.1016/j.csbj.2018.07.004_bb0085) 2002
Peterson (10.1016/j.csbj.2018.07.004_bb0180) 2016
Yue (10.1016/j.csbj.2018.07.004_bb0220) 2016; 40
Berman (10.1016/j.csbj.2018.07.004_bb0005) 2005; 14
Taichman (10.1016/j.csbj.2018.07.004_bb0030) 2016; 164
Rackoff (10.1016/j.csbj.2018.07.004_bb0290) 2018
Zhang (10.1016/j.csbj.2018.07.004_bb0130) 2017
Al Omar (10.1016/j.csbj.2018.07.004_bb0215) 2018
Kim Futrell (10.1016/j.csbj.2018.07.004_bb0240) 2013
Bondi (10.1016/j.csbj.2018.07.004_bb0095) 2018
Buterin (10.1016/j.csbj.2018.07.004_bb0145) 2013
Anthes (10.1016/j.csbj.2018.07.004_bb0310) 2015; 58
Amazon Web Services (10.1016/j.csbj.2018.07.004_bb0315)
Gross (10.1016/j.csbj.2018.07.004_bb0045) 1987; 37
Crockford (10.1016/j.csbj.2018.07.004_bb0265) 2006
Ricke (10.1016/j.csbj.2018.07.004_bb0050) 2000; 36
Dolin (10.1016/j.csbj.2018.07.004_bb0285) 2006; 13
Johnston (10.1016/j.csbj.2018.07.004_bb0150) 2014
Leff (10.1016/j.csbj.2018.07.004_bb0250) 2001
I. G. B. S. P. S. Team (10.1016/j.csbj.2018.07.004_bb0165) 2016
Larose (10.1016/j.csbj.2018.07.004_bb0090) 2011; 28
Krawiec (10.1016/j.csbj.2018.07.004_bb0155) 2018
C. for Disease Control, Prevention (10.1016/j.csbj.2018.07.004_bb0205) 2003; vol. 52
References_xml – year: 2016
  ident: bb0180
  article-title: A blockchain-based approach to health information exchange networks
– start-page: 1
  year: 2017
  end-page: 4
  ident: bb0130
  article-title: Metrics for assessing blockchain-based healthcare decentralized apps
  publication-title: IEEE 19th International Conference on e-Health Networking, Applications and Services (Healthcom)
– year: 2012
  ident: bb0230
  article-title: The oauth 2.0 authorization framework
– year: 2017
  ident: bb0110
  article-title: Does blockchain have a place in healthcare
– start-page: 118
  year: 2001
  end-page: 127
  ident: bb0250
  article-title: Web-application development using the model/view/controller design pattern
  publication-title: Enterprise Distributed Object Computing Conference
– start-page: 310
  year: 2001
  end-page: 331
  ident: bb0260
  article-title: The order of encryption and authentication for protecting communications (or: How secure is ssl?)
  publication-title: Advances in Cryptology—CRYPTO
– year: 2016
  ident: bb0190
  article-title: Powering the physician-patient relationship with hie of one blockchain health it
– volume: vol. 52
  start-page: 1
  year: 2003
  end-page: 17
  ident: bb0205
  article-title: Hipaa privacy rule and public health. guidance from cdc and the us department of health and human services
  publication-title: MMWR: Morbidity and mortality weekly report
– volume: 13
  start-page: 280
  year: 2015
  ident: bb0040
  article-title: Opening clinical trial data: are the voluntary data-sharing portals enough?
  publication-title: BMC Med
– volume: 6
  start-page: 7
  year: 2010
  end-page: 11
  ident: bb0060
  article-title: Ensuring quality cancer care through the oncology workforce
  publication-title: Journal of Oncology Practice
– year: 2018
  ident: bb0175
  article-title: A case study for blockchain in healthcare:“medrec” prototype for electronic health records and medical research data
  publication-title: Proceedings of IEEE Open & Big Data Conference
– volume: 169
  start-page: 1881
  year: 2009
  end-page: 1887
  ident: bb0025
  article-title: Diagnostic error in medicine: analysis of 583 physician-reported errors
  publication-title: Arch Intern Med
– volume: 375
  start-page: 401
  year: 2016
  end-page: 403
  ident: bb0035
  article-title: Strengthening research through data sharing
  publication-title: New England Journal of Medicine
– ident: bb0195
  article-title: Direct project
– year: 2018
  ident: bb0200
  article-title: Blockchains vs centralized databases
– volume: 164
  start-page: 505
  year: 2016
  end-page: 506
  ident: bb0030
  article-title: Sharing clinical trial data: a proposal from the international committee of medical journal editorssharing clinical trial data
  publication-title: Ann Intern Med
– year: 2006
  ident: bb0265
  article-title: The application/json media type for javascript object notation (json)
– volume: 15
  start-page: 1
  year: 2009
  end-page: 5
  ident: bb0065
  article-title: Medical identity theft and telemedicine security
  publication-title: Telemedicine and e-Health
– year: 2002
  ident: bb0085
  article-title: E-health, telehealth, and telemedicine: A guide to startup and success
– year: 2018
  ident: bb0295
  article-title: Understanding zero knowledge blockchains
– ident: bb0270
– year: 2016
  ident: bb0160
  article-title: Co-creation of trust for healthcare: The cryptocitizen. framework for interoperability with blockchain
– ident: bb0235
– volume: 14
  start-page: 559
  year: 2005
  end-page: 573
  ident: bb0005
  article-title: Technology and managed care: patient benefits of telemedicine in a rural health care network
  publication-title: Health Econ
– start-page: 195
  year: 2018
  end-page: 203
  ident: bb0095
  article-title: Characteristics of scalability and their impact on performance
  publication-title: Proceedings of the 2nd international workshop on Software and performance, ACM
– year: 2013
  ident: bb0240
  article-title: Structured data
– start-page: 433
  year: 2018
  end-page: 444
  ident: bb0290
  article-title: Non-interactive zero-knowledge proof of knowledge and chosen ciphertext attack
  publication-title: Annual International Cryptology Conference
– year: 2015
  ident: bb0300
  article-title: Multichain private blockchain white paper
– year: 2015
  ident: bb0140
  article-title: Connecting health and care for the nation: A shared nationwide interoperability roadmap
– volume: 13
  start-page: 30
  year: 2006
  end-page: 39
  ident: bb0285
  article-title: Hl7 clinical document architecture, release 2
  publication-title: J Am Med Inform Assoc
– volume: 21
  start-page: 204
  year: 2014
  end-page: 211
  ident: bb0075
  article-title: Health data use, stewardship, and governance: ongoing gaps and challenges: a report from amia's 2012 health policy meeting
  publication-title: J Am Med Inform Assoc
– start-page: 326
  year: 2013
  end-page: 331
  ident: bb0100
  article-title: Hl7 fhir: An agile and restful approach to healthcare information exchange
  publication-title: Computer-Based Medical Systems (CBMS)
– volume: 173
  start-page: 418
  year: 2013
  end-page: 425
  ident: bb0015
  article-title: Types and origins of diagnostic errors in primary care settings
  publication-title: JAMA Intern Med
– volume: 44
  start-page: 43
  year: 2001
  end-page: 50
  ident: bb0275
  article-title: Using multidimensional separation of concerns to (re) shape evolving software
  publication-title: Communications of the ACM
– start-page: 1
  year: 2016
  end-page: 3
  ident: bb0115
  article-title: Blockchain technology in healthcare: The revolution starts here
  publication-title: e-Health Networking, Applications and Services (Healthcom)
– start-page: 25
  year: 2018
  end-page: 30
  ident: bb0120
  article-title: Medrec: Using blockchain for medical data access and permission management
  publication-title: Open and Big Data (OBD), International Conference on, IEEE
– start-page: 1
  year: 2018
  end-page: 16
  ident: bb0155
  article-title: Blockchain: Opportunities for health care
  publication-title: Proc. NIST Workshop Blockchain Healthcare
– volume: 5
  start-page: 4
  year: 2015
  ident: bb0010
  article-title: Clinical decision support systems for improving diagnostic accuracy and achieving precision medicine
  publication-title: Journal of Clinical Bioinformatics
– volume: 28
  start-page: 91
  year: 2011
  end-page: 100
  ident: bb0090
  article-title: The impact of rural broadband development: lessons from a natural field experiment
  publication-title: Government Information Quarterly
– year: 2016
  ident: bb0165
  article-title: Blockchain: The chain of trust and its potential to transform healthcare – our point of view
– year: 2018
  ident: bb0225
  article-title: Simple contracts are better contracts: What we can learn from the meltdown of the dao
– volume: 37
  start-page: 88
  year: 1987
  end-page: 92
  ident: bb0045
  article-title: The role of the tumor board in a community hospital
  publication-title: CA Cancer J Clin
– volume: 129
  start-page: 82
  year: 2007
  ident: bb0080
  article-title: Challenges in telemedicine and ehealth: lessons learned from 20 years with telemedicine in tromso
  publication-title: Stud Health Technol Inform
– start-page: 534
  year: 2018
  end-page: 543
  ident: bb0215
  article-title: Medibchain: A blockchain based privacy preserving platform for healthcare data
  publication-title: International Conference on Security, Privacy and Anonymity in Computation, Communication and Storage
– start-page: 383
  year: 2018
  end-page: 386
  ident: bb0305
  article-title: Electronic wallet
  publication-title: Advances in Cryptology
– year: 2017
  ident: bb0185
  article-title: Secure and trustable electronic medical records sharing using blockchain
– volume: 42
  start-page: 497
  year: 2009
  end-page: 505
  ident: bb0280
  article-title: Internet voting in comparative perspective: the case of Estonia
  publication-title: PS: Political Science & Politics
– year: 2008
  ident: bb0125
  article-title: Bitcoin: A peer-to-peer electronic cash system
– year: 2018
  ident: bb0315
  article-title: AWS blockchain templates
– volume: 40
  start-page: 218
  year: 2016
  ident: bb0220
  article-title: Healthcare data gateways: found healthcare intelligence on blockchain with novel privacy risk control
  publication-title: J Med Syst
– volume: 36
  start-page: 826
  year: 2000
  end-page: 833
  ident: bb0050
  article-title: Telemedicine and its impact on cancer management
  publication-title: Eur J Cancer
– volume: 20
  start-page: 199
  year: 2013
  end-page: 207
  ident: bb0245
  article-title: Key principles for a national clinical decision support knowledge sharing framework: synthesis of insights from leading subject matter experts
  publication-title: J Am Med Inform Assoc
– year: 1996
  ident: bb0210
  article-title: Handbook of applied cryptography
– volume: 14
  start-page: 687
  year: 2007
  end-page: 696
  ident: bb0105
  article-title: Data standards in clinical research: gaps, overlaps, challenges and future directions
  publication-title: J Am Med Inform Assoc
– year: 2013
  ident: bb0070
  article-title: Sharing clinical research data: Workshop summary
– year: 2013
  ident: bb0145
  article-title: Ethereum white paper
– volume: 163
  start-page: 1409
  year: 2003
  end-page: 1416
  ident: bb0020
  article-title: Effects of computerized physician order entry and clinical decision support systems on medication safety: a systematic review
  publication-title: Arch Intern Med
– year: 2006
  ident: bb0255
  article-title: The secure shell (ssh) protocol architecture
– year: 2014
  ident: bb0150
  article-title: The general theory of decentralized applications, dapps, GitHub, June 9
– volume: 58
  start-page: 18
  year: 2015
  end-page: 20
  ident: bb0310
  article-title: Estonia: a model for e-government
  publication-title: Communications of the ACM
– volume: 20
  start-page: 705
  year: 2014
  end-page: 711
  ident: bb0055
  article-title: Implementation of a regional virtual tumor board: a prospective study evaluating feasibility and provider acceptance
  publication-title: Telemedicine and e-Health
– year: 2017
  ident: bb0135
  article-title: Applying software patterns to address interoperability in blockchain-based healthcare apps, the 24th pattern languages of programming conference
– volume: 24
  start-page: 1211
  year: 2017
  end-page: 1220
  ident: bb0170
  article-title: Blockchain distributed ledger technologies for biomedical and health care applications
  publication-title: J Am Med Inform Assoc
– year: 2012
  ident: 10.1016/j.csbj.2018.07.004_bb0230
– volume: 40
  start-page: 218
  year: 2016
  ident: 10.1016/j.csbj.2018.07.004_bb0220
  article-title: Healthcare data gateways: found healthcare intelligence on blockchain with novel privacy risk control
  publication-title: J Med Syst
  doi: 10.1007/s10916-016-0574-6
– ident: 10.1016/j.csbj.2018.07.004_bb0300
– year: 2017
  ident: 10.1016/j.csbj.2018.07.004_bb0110
– volume: vol. 52
  start-page: 1
  year: 2003
  ident: 10.1016/j.csbj.2018.07.004_bb0205
  article-title: Hipaa privacy rule and public health. guidance from cdc and the us department of health and human services
– year: 2014
  ident: 10.1016/j.csbj.2018.07.004_bb0150
– volume: 20
  start-page: 199
  year: 2013
  ident: 10.1016/j.csbj.2018.07.004_bb0245
  article-title: Key principles for a national clinical decision support knowledge sharing framework: synthesis of insights from leading subject matter experts
  publication-title: J Am Med Inform Assoc
  doi: 10.1136/amiajnl-2012-000887
– volume: 164
  start-page: 505
  year: 2016
  ident: 10.1016/j.csbj.2018.07.004_bb0030
  article-title: Sharing clinical trial data: a proposal from the international committee of medical journal editorssharing clinical trial data
  publication-title: Ann Intern Med
  doi: 10.7326/M15-2928
– volume: 42
  start-page: 497
  year: 2009
  ident: 10.1016/j.csbj.2018.07.004_bb0280
  article-title: Internet voting in comparative perspective: the case of Estonia
  publication-title: PS: Political Science & Politics
– year: 2002
  ident: 10.1016/j.csbj.2018.07.004_bb0085
– year: 2013
  ident: 10.1016/j.csbj.2018.07.004_bb0240
– ident: 10.1016/j.csbj.2018.07.004_bb0235
– ident: 10.1016/j.csbj.2018.07.004_bb0200
– start-page: 310
  year: 2001
  ident: 10.1016/j.csbj.2018.07.004_bb0260
  article-title: The order of encryption and authentication for protecting communications (or: How secure is ssl?)
– start-page: 1
  year: 2016
  ident: 10.1016/j.csbj.2018.07.004_bb0115
  article-title: Blockchain technology in healthcare: The revolution starts here
– year: 2008
  ident: 10.1016/j.csbj.2018.07.004_bb0125
– start-page: 1
  year: 2018
  ident: 10.1016/j.csbj.2018.07.004_bb0155
  article-title: Blockchain: Opportunities for health care
– volume: 15
  start-page: 1
  year: 2009
  ident: 10.1016/j.csbj.2018.07.004_bb0065
  article-title: Medical identity theft and telemedicine security
  publication-title: Telemedicine and e-Health
– ident: 10.1016/j.csbj.2018.07.004_bb0195
– ident: 10.1016/j.csbj.2018.07.004_bb0295
– ident: 10.1016/j.csbj.2018.07.004_bb0225
– volume: 14
  start-page: 559
  year: 2005
  ident: 10.1016/j.csbj.2018.07.004_bb0005
  article-title: Technology and managed care: patient benefits of telemedicine in a rural health care network
  publication-title: Health Econ
  doi: 10.1002/hec.952
– volume: 163
  start-page: 1409
  year: 2003
  ident: 10.1016/j.csbj.2018.07.004_bb0020
  article-title: Effects of computerized physician order entry and clinical decision support systems on medication safety: a systematic review
  publication-title: Arch Intern Med
  doi: 10.1001/archinte.163.12.1409
– year: 2013
  ident: 10.1016/j.csbj.2018.07.004_bb0145
– year: 2006
  ident: 10.1016/j.csbj.2018.07.004_bb0265
– volume: 58
  start-page: 18
  year: 2015
  ident: 10.1016/j.csbj.2018.07.004_bb0310
  article-title: Estonia: a model for e-government
  publication-title: Communications of the ACM
  doi: 10.1145/2754951
– volume: 169
  start-page: 1881
  year: 2009
  ident: 10.1016/j.csbj.2018.07.004_bb0025
  article-title: Diagnostic error in medicine: analysis of 583 physician-reported errors
  publication-title: Arch Intern Med
  doi: 10.1001/archinternmed.2009.333
– year: 2018
  ident: 10.1016/j.csbj.2018.07.004_bb0175
  article-title: A case study for blockchain in healthcare:“medrec” prototype for electronic health records and medical research data
– ident: 10.1016/j.csbj.2018.07.004_bb0270
– volume: 44
  start-page: 43
  year: 2001
  ident: 10.1016/j.csbj.2018.07.004_bb0275
  article-title: Using multidimensional separation of concerns to (re) shape evolving software
  publication-title: Communications of the ACM
  doi: 10.1145/383845.383856
– volume: 24
  start-page: 1211
  year: 2017
  ident: 10.1016/j.csbj.2018.07.004_bb0170
  article-title: Blockchain distributed ledger technologies for biomedical and health care applications
  publication-title: J Am Med Inform Assoc
  doi: 10.1093/jamia/ocx068
– start-page: 433
  year: 2018
  ident: 10.1016/j.csbj.2018.07.004_bb0290
  article-title: Non-interactive zero-knowledge proof of knowledge and chosen ciphertext attack
– volume: 37
  start-page: 88
  year: 1987
  ident: 10.1016/j.csbj.2018.07.004_bb0045
  article-title: The role of the tumor board in a community hospital
  publication-title: CA Cancer J Clin
– start-page: 326
  year: 2013
  ident: 10.1016/j.csbj.2018.07.004_bb0100
  article-title: Hl7 fhir: An agile and restful approach to healthcare information exchange
– year: 2013
  ident: 10.1016/j.csbj.2018.07.004_bb0070
– start-page: 118
  year: 2001
  ident: 10.1016/j.csbj.2018.07.004_bb0250
  article-title: Web-application development using the model/view/controller design pattern
– year: 2016
  ident: 10.1016/j.csbj.2018.07.004_bb0180
– volume: 129
  start-page: 82
  year: 2007
  ident: 10.1016/j.csbj.2018.07.004_bb0080
  article-title: Challenges in telemedicine and ehealth: lessons learned from 20 years with telemedicine in tromso
  publication-title: Stud Health Technol Inform
– start-page: 383
  year: 2018
  ident: 10.1016/j.csbj.2018.07.004_bb0305
  article-title: Electronic wallet
– volume: 6
  start-page: 7
  year: 2010
  ident: 10.1016/j.csbj.2018.07.004_bb0060
  article-title: Ensuring quality cancer care through the oncology workforce
  publication-title: Journal of Oncology Practice
  doi: 10.1200/JOP.091067
– year: 2016
  ident: 10.1016/j.csbj.2018.07.004_bb0160
– year: 2017
  ident: 10.1016/j.csbj.2018.07.004_bb0135
– start-page: 534
  year: 2018
  ident: 10.1016/j.csbj.2018.07.004_bb0215
  article-title: Medibchain: A blockchain based privacy preserving platform for healthcare data
– ident: 10.1016/j.csbj.2018.07.004_bb0315
– volume: 13
  start-page: 280
  year: 2015
  ident: 10.1016/j.csbj.2018.07.004_bb0040
  article-title: Opening clinical trial data: are the voluntary data-sharing portals enough?
  publication-title: BMC Med
  doi: 10.1186/s12916-015-0525-y
– volume: 28
  start-page: 91
  year: 2011
  ident: 10.1016/j.csbj.2018.07.004_bb0090
  article-title: The impact of rural broadband development: lessons from a natural field experiment
  publication-title: Government Information Quarterly
  doi: 10.1016/j.giq.2009.12.013
– volume: 14
  start-page: 687
  year: 2007
  ident: 10.1016/j.csbj.2018.07.004_bb0105
  article-title: Data standards in clinical research: gaps, overlaps, challenges and future directions
  publication-title: J Am Med Inform Assoc
  doi: 10.1197/jamia.M2470
– start-page: 1
  year: 2017
  ident: 10.1016/j.csbj.2018.07.004_bb0130
  article-title: Metrics for assessing blockchain-based healthcare decentralized apps
– year: 1996
  ident: 10.1016/j.csbj.2018.07.004_bb0210
– start-page: 25
  year: 2018
  ident: 10.1016/j.csbj.2018.07.004_bb0120
  article-title: Medrec: Using blockchain for medical data access and permission management
– volume: 20
  start-page: 705
  year: 2014
  ident: 10.1016/j.csbj.2018.07.004_bb0055
  article-title: Implementation of a regional virtual tumor board: a prospective study evaluating feasibility and provider acceptance
  publication-title: Telemedicine and e-Health
  doi: 10.1089/tmj.2013.0320
– volume: 173
  start-page: 418
  year: 2013
  ident: 10.1016/j.csbj.2018.07.004_bb0015
  article-title: Types and origins of diagnostic errors in primary care settings
  publication-title: JAMA Intern Med
  doi: 10.1001/jamainternmed.2013.2777
– year: 2016
  ident: 10.1016/j.csbj.2018.07.004_bb0190
– year: 2016
  ident: 10.1016/j.csbj.2018.07.004_bb0165
– start-page: 195
  year: 2018
  ident: 10.1016/j.csbj.2018.07.004_bb0095
  article-title: Characteristics of scalability and their impact on performance
– volume: 13
  start-page: 30
  year: 2006
  ident: 10.1016/j.csbj.2018.07.004_bb0285
  article-title: Hl7 clinical document architecture, release 2
  publication-title: J Am Med Inform Assoc
  doi: 10.1197/jamia.M1888
– volume: 375
  start-page: 401
  year: 2016
  ident: 10.1016/j.csbj.2018.07.004_bb0035
  article-title: Strengthening research through data sharing
  publication-title: New England Journal of Medicine
  doi: 10.1056/NEJMp1607282
– volume: 21
  start-page: 204
  year: 2014
  ident: 10.1016/j.csbj.2018.07.004_bb0075
  article-title: Health data use, stewardship, and governance: ongoing gaps and challenges: a report from amia's 2012 health policy meeting
  publication-title: J Am Med Inform Assoc
  doi: 10.1136/amiajnl-2013-002117
– year: 2006
  ident: 10.1016/j.csbj.2018.07.004_bb0255
– volume: 5
  start-page: 4
  year: 2015
  ident: 10.1016/j.csbj.2018.07.004_bb0010
  article-title: Clinical decision support systems for improving diagnostic accuracy and achieving precision medicine
  publication-title: Journal of Clinical Bioinformatics
  doi: 10.1186/s13336-015-0019-3
– year: 2015
  ident: 10.1016/j.csbj.2018.07.004_bb0140
  article-title: Connecting health and care for the nation: A shared nationwide interoperability roadmap
– volume: 36
  start-page: 826
  year: 2000
  ident: 10.1016/j.csbj.2018.07.004_bb0050
  article-title: Telemedicine and its impact on cancer management
  publication-title: Eur J Cancer
  doi: 10.1016/S0959-8049(00)00057-5
– year: 2017
  ident: 10.1016/j.csbj.2018.07.004_bb0185
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Snippet Secure and scalable data sharing is essential for collaborative clinical decision making. Conventional clinical data efforts are often siloed, however, which...
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StartPage 267
SubjectTerms Blockchain
Cancer care
case studies
Clinical data sharing
Decentralized app
decision making
Digital health identity
encapsulation
health information
health services
information exchange
information technology
Interoperability
neoplasms
patients
Smart contracts
Title FHIRChain: Applying Blockchain to Securely and Scalably Share Clinical Data
URI https://dx.doi.org/10.1016/j.csbj.2018.07.004
https://www.ncbi.nlm.nih.gov/pubmed/30108685
https://www.proquest.com/docview/2088746404
https://www.proquest.com/docview/2153608545
https://pubmed.ncbi.nlm.nih.gov/PMC6082774
https://doaj.org/article/3067fff678f340beb9fd43f7636ce82c
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