Mild hyperthermia inhibits homologous recombination, induces BRCA2 degradation, and sensitizes cancer cells to poly (ADP-ribose) polymerase-1 inhibition

Defective homologous recombination (HR) DNA repair imposed by BRCA1 or BRCA2 deficiency sensitizes cells to poly (ADP-ribose) polymerase (PARP)-1 inhibition and is currently exploited in clinical treatment of HR-deficient tumors. Here we show that mild hyperthermia (41-42.5 °C) induces degradation o...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS Jg. 108; H. 24; S. 9851
Hauptverfasser:	Krawczyk, Przemek M, Eppink, Berina, Essers, Jeroen, Stap, Jan, Rodermond, Hans, Odijk, Hanny, Zelensky, Alex, van Bree, Chris, Stalpers, Lukas J, Buist, Marrije R, Soullié, Thomas, Rens, Joost, Verhagen, Hence J M, O'Connor, Mark J, Franken, Nicolaas A P, Ten Hagen, Timo L M, Kanaar, Roland, Aten, Jacob A
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	United States 14.06.2011
Schlagworte:	Animals Benzoquinones - pharmacology BRCA2 Protein - genetics BRCA2 Protein - metabolism Cell Line Cell Line, Tumor Cells, Cultured DNA Repair DNA-Binding Proteins - genetics DNA-Binding Proteins - metabolism Embryonic Stem Cells - drug effects Embryonic Stem Cells - metabolism Embryonic Stem Cells - radiation effects Female HeLa Cells Hot Temperature Humans Immunoblotting Lactams, Macrocyclic - pharmacology Mice Mice, Nude Neoplasms, Experimental - genetics Neoplasms, Experimental - metabolism Neoplasms, Experimental - pathology Phthalazines - pharmacology Piperazines - pharmacology Poly(ADP-ribose) Polymerase Inhibitors Poly(ADP-ribose) Polymerases - genetics Poly(ADP-ribose) Polymerases - metabolism Quinazolines - pharmacology Rats Recombination, Genetic - drug effects Recombination, Genetic - genetics Recombination, Genetic - radiation effects RNA Interference Transplantation, Heterologous Tumor Burden - drug effects
ISSN:	1091-6490, 1091-6490
Online-Zugang:	Weitere Angaben
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