Mild hyperthermia inhibits homologous recombination, induces BRCA2 degradation, and sensitizes cancer cells to poly (ADP-ribose) polymerase-1 inhibition
Defective homologous recombination (HR) DNA repair imposed by BRCA1 or BRCA2 deficiency sensitizes cells to poly (ADP-ribose) polymerase (PARP)-1 inhibition and is currently exploited in clinical treatment of HR-deficient tumors. Here we show that mild hyperthermia (41-42.5 °C) induces degradation o...
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| Vydané v: | Proceedings of the National Academy of Sciences - PNAS Ročník 108; číslo 24; s. 9851 |
|---|---|
| Hlavní autori: | , , , , , , , , , , , , , , , , , |
| Médium: | Journal Article |
| Jazyk: | English |
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United States
14.06.2011
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| ISSN: | 1091-6490, 1091-6490 |
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| Abstract | Defective homologous recombination (HR) DNA repair imposed by BRCA1 or BRCA2 deficiency sensitizes cells to poly (ADP-ribose) polymerase (PARP)-1 inhibition and is currently exploited in clinical treatment of HR-deficient tumors. Here we show that mild hyperthermia (41-42.5 °C) induces degradation of BRCA2 and inhibits HR. We demonstrate that hyperthermia can be used to sensitize innately HR-proficient tumor cells to PARP-1 inhibitors and that this effect can be enhanced by heat shock protein inhibition. Our results, obtained from cell lines and in vivo tumor models, enable the design of unique therapeutic strategies involving localized on-demand induction of HR deficiency, an approach that we term induced synthetic lethality. |
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| AbstractList | Defective homologous recombination (HR) DNA repair imposed by BRCA1 or BRCA2 deficiency sensitizes cells to poly (ADP-ribose) polymerase (PARP)-1 inhibition and is currently exploited in clinical treatment of HR-deficient tumors. Here we show that mild hyperthermia (41-42.5 °C) induces degradation of BRCA2 and inhibits HR. We demonstrate that hyperthermia can be used to sensitize innately HR-proficient tumor cells to PARP-1 inhibitors and that this effect can be enhanced by heat shock protein inhibition. Our results, obtained from cell lines and in vivo tumor models, enable the design of unique therapeutic strategies involving localized on-demand induction of HR deficiency, an approach that we term induced synthetic lethality. Defective homologous recombination (HR) DNA repair imposed by BRCA1 or BRCA2 deficiency sensitizes cells to poly (ADP-ribose) polymerase (PARP)-1 inhibition and is currently exploited in clinical treatment of HR-deficient tumors. Here we show that mild hyperthermia (41-42.5 °C) induces degradation of BRCA2 and inhibits HR. We demonstrate that hyperthermia can be used to sensitize innately HR-proficient tumor cells to PARP-1 inhibitors and that this effect can be enhanced by heat shock protein inhibition. Our results, obtained from cell lines and in vivo tumor models, enable the design of unique therapeutic strategies involving localized on-demand induction of HR deficiency, an approach that we term induced synthetic lethality.Defective homologous recombination (HR) DNA repair imposed by BRCA1 or BRCA2 deficiency sensitizes cells to poly (ADP-ribose) polymerase (PARP)-1 inhibition and is currently exploited in clinical treatment of HR-deficient tumors. Here we show that mild hyperthermia (41-42.5 °C) induces degradation of BRCA2 and inhibits HR. We demonstrate that hyperthermia can be used to sensitize innately HR-proficient tumor cells to PARP-1 inhibitors and that this effect can be enhanced by heat shock protein inhibition. Our results, obtained from cell lines and in vivo tumor models, enable the design of unique therapeutic strategies involving localized on-demand induction of HR deficiency, an approach that we term induced synthetic lethality. |
| Author | Rens, Joost Zelensky, Alex Verhagen, Hence J M Eppink, Berina van Bree, Chris Stalpers, Lukas J Franken, Nicolaas A P Ten Hagen, Timo L M Krawczyk, Przemek M Rodermond, Hans Soullié, Thomas Essers, Jeroen Buist, Marrije R O'Connor, Mark J Kanaar, Roland Odijk, Hanny Stap, Jan Aten, Jacob A |
| Author_xml | – sequence: 1 givenname: Przemek M surname: Krawczyk fullname: Krawczyk, Przemek M organization: Van Leeuwenhoek Centre for Advanced Microscopy-AMC, Department of Cell Biology and Histology, Academic Medical Center, University of Amsterdam, 1105 AZ Amsterdam, The Netherlands – sequence: 2 givenname: Berina surname: Eppink fullname: Eppink, Berina – sequence: 3 givenname: Jeroen surname: Essers fullname: Essers, Jeroen – sequence: 4 givenname: Jan surname: Stap fullname: Stap, Jan – sequence: 5 givenname: Hans surname: Rodermond fullname: Rodermond, Hans – sequence: 6 givenname: Hanny surname: Odijk fullname: Odijk, Hanny – sequence: 7 givenname: Alex surname: Zelensky fullname: Zelensky, Alex – sequence: 8 givenname: Chris surname: van Bree fullname: van Bree, Chris – sequence: 9 givenname: Lukas J surname: Stalpers fullname: Stalpers, Lukas J – sequence: 10 givenname: Marrije R surname: Buist fullname: Buist, Marrije R – sequence: 11 givenname: Thomas surname: Soullié fullname: Soullié, Thomas – sequence: 12 givenname: Joost surname: Rens fullname: Rens, Joost – sequence: 13 givenname: Hence J M surname: Verhagen fullname: Verhagen, Hence J M – sequence: 14 givenname: Mark J surname: O'Connor fullname: O'Connor, Mark J – sequence: 15 givenname: Nicolaas A P surname: Franken fullname: Franken, Nicolaas A P – sequence: 16 givenname: Timo L M surname: Ten Hagen fullname: Ten Hagen, Timo L M – sequence: 17 givenname: Roland surname: Kanaar fullname: Kanaar, Roland – sequence: 18 givenname: Jacob A surname: Aten fullname: Aten, Jacob A |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/21555554$$D View this record in MEDLINE/PubMed |
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| References | 11988766 - Nat Rev Mol Cell Biol. 2002 May;3(5):317-27 10446958 - Cancer Res. 1999 Aug 1;59(15):3547-51 4981449 - Eur J Cancer. 1969 Sep;5(4):373-91 18264087 - Nature. 2008 Feb 28;451(7182):1116-20 10373565 - Mol Cell Biol. 1999 Jul;19(7):5166-9 11238998 - Nucleic Acids Res. 2001 Mar 15;29(6):1317-25 18084321 - Oncogene. 2008 May 29;27(24):3361-70 18214766 - Int J Hyperthermia. 2008 Feb;24(1):17-29 9789328 - Trends Cell Biol. 1998 Oct;8(10):397-403 17083915 - Biochem Biophys Res Commun. 2006 Dec 22;351(3):658-63 2394928 - Int J Hyperthermia. 1990 Jul-Aug;6(4):801-12 3965144 - Cancer Res. 1985 Jan;45(1):345-50 14731068 - Radiat Res. 2004 Feb;161(2):215-8 11953322 - EMBO J. 2002 Apr 15;21(8):2030-7 15829966 - Nature. 2005 Apr 14;434(7035):913-7 11304434 - Int J Radiat Biol. 2001 Apr;77(4):399-408 20434400 - Lancet Oncol. 2010 Jun;11(6):561-70 16513631 - J Biol Chem. 2006 Apr 28;281(17):11649-57 12891712 - J Cell Physiol. 2003 Sep;196(3):557-64 17965729 - Nature. 2007 Nov 22;450(7169):509-14 12531026 - DNA Repair (Amst). 2002 Oct 1;1(10):779-93 15195507 - Int J Hyperthermia. 2004 Mar;20(2):131-9 15195514 - Int J Hyperthermia. 2004 Mar;20(2):201-12 15447039 - Radiat Res. 2004 Oct;162(4):433-41 18048823 - J Clin Oncol. 2007 Dec 1;25(34):5410-7 15297881 - EMBO J. 2004 Sep 1;23(17):3548-58 19553641 - N Engl J Med. 2009 Jul 9;361(2):123-34 18497818 - Nature. 2008 May 22;453(7194):489-4 1918136 - J Cell Biol. 1991 Oct;115(1):191-9 18066095 - Oncogene. 2007 Dec 10;26(56):7816-24 15829967 - Nature. 2005 Apr 14;434(7035):917-21 63357 - Chromosoma. 1976 Sep 10;57(3):219-25 8103547 - Int J Radiat Biol. 1993 Aug;64(2):225-30 18166980 - Cell Res. 2008 Jan;18(1):114-24 16618811 - J Cell Biol. 2006 Apr 24;173(2):195-206 18066084 - Oncogene. 2007 Dec 10;26(56):7720-30 12483514 - Oncogene. 2002 Dec 16;21(58):8981-93 16982765 - Cancer Res. 2006 Sep 15;66(18):9211-20 7272422 - Biometrics. 1981 Jun;37(2):383-90 9108475 - Cell. 1997 Apr 18;89(2):195-204 18275380 - Annu Rev Biochem. 2008;77:229-57 19047122 - Clin Cancer Res. 2008 Dec 1;14(23):7917-23 18309310 - Nat Methods. 2008 Mar;5(3):261-6 18264088 - Nature. 2008 Feb 28;451(7182):1111-5 21642535 - Proc Natl Acad Sci U S A. 2011 Jun 14;108(24):9731-2 11139322 - Br J Cancer. 2001 Jan 5;84(1):106-12 8515141 - Int J Hyperthermia. 1993 May-Jun;9(3):383-91 17996710 - Mol Cell. 2007 Nov 9;28(3):468-81 |
| References_xml | – reference: 18084321 - Oncogene. 2008 May 29;27(24):3361-70 – reference: 9108475 - Cell. 1997 Apr 18;89(2):195-204 – reference: 21642535 - Proc Natl Acad Sci U S A. 2011 Jun 14;108(24):9731-2 – reference: 12483514 - Oncogene. 2002 Dec 16;21(58):8981-93 – reference: 4981449 - Eur J Cancer. 1969 Sep;5(4):373-91 – reference: 15829967 - Nature. 2005 Apr 14;434(7035):917-21 – reference: 18166980 - Cell Res. 2008 Jan;18(1):114-24 – reference: 7272422 - Biometrics. 1981 Jun;37(2):383-90 – reference: 18264087 - Nature. 2008 Feb 28;451(7182):1116-20 – reference: 19553641 - N Engl J Med. 2009 Jul 9;361(2):123-34 – reference: 20434400 - Lancet Oncol. 2010 Jun;11(6):561-70 – reference: 63357 - Chromosoma. 1976 Sep 10;57(3):219-25 – reference: 18066095 - Oncogene. 2007 Dec 10;26(56):7816-24 – reference: 18497818 - Nature. 2008 May 22;453(7194):489-4 – reference: 15447039 - Radiat Res. 2004 Oct;162(4):433-41 – reference: 17965729 - Nature. 2007 Nov 22;450(7169):509-14 – reference: 11988766 - Nat Rev Mol Cell Biol. 2002 May;3(5):317-27 – reference: 3965144 - Cancer Res. 1985 Jan;45(1):345-50 – reference: 10373565 - Mol Cell Biol. 1999 Jul;19(7):5166-9 – reference: 18214766 - Int J Hyperthermia. 2008 Feb;24(1):17-29 – reference: 11953322 - EMBO J. 2002 Apr 15;21(8):2030-7 – reference: 12891712 - J Cell Physiol. 2003 Sep;196(3):557-64 – reference: 8103547 - Int J Radiat Biol. 1993 Aug;64(2):225-30 – reference: 18066084 - Oncogene. 2007 Dec 10;26(56):7720-30 – reference: 16618811 - J Cell Biol. 2006 Apr 24;173(2):195-206 – reference: 18275380 - Annu Rev Biochem. 2008;77:229-57 – reference: 15195507 - Int J Hyperthermia. 2004 Mar;20(2):131-9 – reference: 1918136 - J Cell Biol. 1991 Oct;115(1):191-9 – reference: 12531026 - DNA Repair (Amst). 2002 Oct 1;1(10):779-93 – reference: 11139322 - Br J Cancer. 2001 Jan 5;84(1):106-12 – reference: 8515141 - Int J Hyperthermia. 1993 May-Jun;9(3):383-91 – reference: 15829966 - Nature. 2005 Apr 14;434(7035):913-7 – reference: 9789328 - Trends Cell Biol. 1998 Oct;8(10):397-403 – reference: 18048823 - J Clin Oncol. 2007 Dec 1;25(34):5410-7 – reference: 15297881 - EMBO J. 2004 Sep 1;23(17):3548-58 – reference: 2394928 - Int J Hyperthermia. 1990 Jul-Aug;6(4):801-12 – reference: 10446958 - Cancer Res. 1999 Aug 1;59(15):3547-51 – reference: 11304434 - Int J Radiat Biol. 2001 Apr;77(4):399-408 – reference: 18264088 - Nature. 2008 Feb 28;451(7182):1111-5 – reference: 17996710 - Mol Cell. 2007 Nov 9;28(3):468-81 – reference: 11238998 - Nucleic Acids Res. 2001 Mar 15;29(6):1317-25 – reference: 18309310 - Nat Methods. 2008 Mar;5(3):261-6 – reference: 17083915 - Biochem Biophys Res Commun. 2006 Dec 22;351(3):658-63 – reference: 14731068 - Radiat Res. 2004 Feb;161(2):215-8 – reference: 16982765 - Cancer Res. 2006 Sep 15;66(18):9211-20 – reference: 15195514 - Int J Hyperthermia. 2004 Mar;20(2):201-12 – reference: 19047122 - Clin Cancer Res. 2008 Dec 1;14(23):7917-23 – reference: 16513631 - J Biol Chem. 2006 Apr 28;281(17):11649-57 |
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| SubjectTerms | Animals Benzoquinones - pharmacology BRCA2 Protein - genetics BRCA2 Protein - metabolism Cell Line Cell Line, Tumor Cells, Cultured DNA Repair DNA-Binding Proteins - genetics DNA-Binding Proteins - metabolism Embryonic Stem Cells - drug effects Embryonic Stem Cells - metabolism Embryonic Stem Cells - radiation effects Female HeLa Cells Hot Temperature Humans Immunoblotting Lactams, Macrocyclic - pharmacology Mice Mice, Nude Neoplasms, Experimental - genetics Neoplasms, Experimental - metabolism Neoplasms, Experimental - pathology Phthalazines - pharmacology Piperazines - pharmacology Poly(ADP-ribose) Polymerase Inhibitors Poly(ADP-ribose) Polymerases - genetics Poly(ADP-ribose) Polymerases - metabolism Quinazolines - pharmacology Rats Recombination, Genetic - drug effects Recombination, Genetic - genetics Recombination, Genetic - radiation effects RNA Interference Transplantation, Heterologous Tumor Burden - drug effects |
| Title | Mild hyperthermia inhibits homologous recombination, induces BRCA2 degradation, and sensitizes cancer cells to poly (ADP-ribose) polymerase-1 inhibition |
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