A proteomic atlas of senescence-associated secretomes for aging biomarker development

The senescence-associated secretory phenotype (SASP) has recently emerged as a driver of and promising therapeutic target for multiple age-related conditions, ranging from neurodegeneration to cancer. The complexity of the SASP, typically assessed by a few dozen secreted proteins, has been greatly u...

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Veröffentlicht in:	PLoS biology Jg. 18; H. 1; S. e3000599
Hauptverfasser:	Basisty, Nathan, Kale, Abhijit, Jeon, Ok Hee, Kuehnemann, Chisaka, Payne, Therese, Rao, Chirag, Holtz, Anja, Shah, Samah, Sharma, Vagisha, Ferrucci, Luigi, Campisi, Judith, Schilling, Birgit
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	United States Public Library of Science 01.01.2020 Public Library of Science (PLoS)
Schlagworte:	Aging Aging - metabolism Arthritis BASIC BIOLOGICAL SCIENCES Biology and Life Sciences Biomarkers Biomarkers - analysis Biomarkers - metabolism Blood plasma Candidates Cell division Cells, Cultured Cellular Senescence - physiology Correlation analysis Cytokines Databases, Protein Deoxyribonucleic acid DNA epithelial cells exosomes Exosomes - chemistry Exosomes - metabolism Female Fibroblasts Gene expression Genotype & phenotype Growth factors HIV Human immunodeficiency virus Humans Laboratories Longitudinal studies Mass spectrometry Medicine and Health Sciences Methods and Resources Neurodegeneration Phenotype Phenotypes Protease inhibitors Proteinase inhibitors Proteins Proteome - analysis Proteome - metabolism Proteomics Scientific imaging Secretory Pathway - physiology Senescence Serine Serine proteinase Serine proteinase inhibitors Software Stanniocalcin Therapeutic applications transcriptome analysis United States > US California
ISSN:	1545-7885, 1544-9173, 1545-7885
Online-Zugang:	Volltext
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