Sertraline or mirtazapine for depression in dementia (HTA-SADD): a randomised, multicentre, double-blind, placebo-controlled trial

Depression is common in dementia but the evidence base for appropriate drug treatment is sparse and equivocal. We aimed to assess efficacy and safety of two of the most commonly prescribed drugs, sertraline and mirtazapine, compared with placebo. We undertook the parallel-group, double-blind, placeb...

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Bibliographic Details
Published in:	The Lancet (British edition) Vol. 378; no. 9789; pp. 403 - 411
Main Authors:	Banerjee, Sube, Hellier, Jennifer, Dewey, Michael, Romeo, Renee, Ballard, Clive, Baldwin, Robert, Bentham, Peter, Fox, Chris, Holmes, Clive, Katona, Cornelius, Knapp, Martin, Lawton, Claire, Lindesay, James, Livingston, Gill, McCrae, Niall, Moniz-Cook, Esme, Murray, Joanna, Nurock, Shirley, Orrell, Martin, O'Brien, John, Poppe, Michaela, Thomas, Alan, Walwyn, Rebecca, Wilson, Kenneth, Burns, Alistair
Format:	Journal Article
Language:	English
Published:	Kidlington Elsevier Ltd 2011 Elsevier Elsevier Limited
Subjects:	Adult and adolescent clinical studies adverse effects Aged Aged, 80 and over Alzheimer disease Alzheimer Disease - complications Alzheimer's disease Antidepressants Antidepressive Agents - adverse effects Antidepressive Agents - therapeutic use Biological and medical sciences Clinical medicine Clinical trials Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases Dementia Dementia - complications Dementia disorders Depression Depressive Disorder - complications Depressive Disorder - drug therapy Double-Blind Method drug therapy Drugs England Female General aspects Health services Humans Internal Medicine Male Medical research Medical sciences Meetings Mental depression Mental Disorders - complications Mental Disorders - drug therapy Mental health Mianserin - adverse effects Mianserin - analogs & derivatives Mianserin - therapeutic use Mirtazapine Mood disorders Mortality Neurodegenerative diseases Neurology patients Psychiatry Psychology. Psychoanalysis. Psychiatry Psychopathology. Psychiatry Randomized Controlled Trials as Topic risk sertraline Sertraline - adverse effects Sertraline - therapeutic use Side effects Suicide Technology assessment Workers England British Isles, England British Isles British Isles, England, Greater London, London α2-Adrenergic receptor Mood disorder Serotonin Psychotropic Multicenter study Depression Tetracyclic compound Reuptake inhibitor Sertraline Randomized controlled trial Selective serotonin reuptake inhibitor Medicine Naphthylamine derivatives Neurotransmitter Double blind study Mirtazapine Antidepressant agent Clinical trial Degenerative disease Antagonist Dementia
ISSN:	0140-6736, 1474-547X, 1474-547X
Online Access:	Get full text
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