Epidemiology of Mycobacterium bovis Disease in Humans, the Netherlands, 1993–2007

In the Netherlands, 1.4% of tuberculosis (TB) cases are caused by Mycobacterium bovis. After we admitted 3 patients with M. bovis infections to our reference hospital, we conducted a retrospective analysis of all M. bovis disease in the Netherlands during 1993-2007. We analyzed data from 231 patient...

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Bibliographic Details
Published in:Emerging infectious diseases Vol. 17; no. 3; pp. 457 - 463
Main Authors: Majoor, Christof J., Magis-Escurra, Cecile, van Ingen, Jakko, Boeree, Martin J., van Soolingen, Dick
Format: Journal Article
Language:English
Published: United States U.S. National Center for Infectious Diseases 01.03.2011
Centers for Disease Control and Prevention
Subjects:
Adolescent
Adult
Aged
Aged, 80 and over
Anti-infective agents
anti-TNF-α
Antitubercular Agents - therapeutic use
Bacterial infections
Care and treatment
Child
Child, Preschool
Cross infection
Development and progression
Diseases
DNA
DNA Fingerprinting
Drug therapy, Combination
Emigrants and Immigrants - statistics & numerical data
Epidemiology
Ethambutol
Female
Food contamination
Humans
Infant
Infant, Newborn
M. bovis
M. tuberculosis disease
Male
Middle Aged
Mycobacterium bovis
Mycobacterium bovis - classification
Mycobacterium bovis - genetics
Mycobacterium bovis - isolation & purification
Netherlands
Netherlands - epidemiology
Nosocomial infections
Rheumatoid arthritis
Rheumatoid factor
Risk Factors
Treatment Outcome
Tuberculosis
Tuberculosis - diagnosis
Tuberculosis - drug therapy
Tuberculosis - epidemiology
Tuberculosis - microbiology
tuberculosis and other mycobacteria
Tuberculosis, Lymph Node - diagnosis
Tuberculosis, Lymph Node - drug therapy
Tuberculosis, Lymph Node - epidemiology
Tuberculosis, Lymph Node - microbiology
Tuberculosis, Pulmonary - diagnosis
Tuberculosis, Pulmonary - drug therapy
Tuberculosis, Pulmonary - epidemiology
Tuberculosis, Pulmonary - microbiology
Netherlands
ISSN:1080-6040, 1080-6059, 1080-6059
Online Access:Get full text
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Summary:In the Netherlands, 1.4% of tuberculosis (TB) cases are caused by Mycobacterium bovis. After we admitted 3 patients with M. bovis infections to our reference hospital, we conducted a retrospective analysis of all M. bovis disease in the Netherlands during 1993-2007. We analyzed data from 231 patients for clinical, demographic, treatment, and outcome characteristics and for risk factors. Most patients were native Dutch (n = 138; 59.7%) or Moroccan (n = 54; 23.4%). Disease was mainly extrapulmonary (n = 136; 58.9%). Although 95 patients had pulmonary disease, person-to-person transmission did not occur, as shown by structural DNA fingerprinting analysis. Lymph node TB was more likely to develop in women (p<0.0001), whereas pulmonary M. bovis disease developed more frequently in men (p<0.0001). Diagnosis was accurate but delayed and led to inadequate treatment in 26% of the cases. Proportion of deaths from M. bovis disease was higher than that for M. tuberculosis disease.
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ISSN:1080-6040
1080-6059
1080-6059
DOI:10.3201/eid1703.101111