Molecular mechanism of IKK catalytic dimer docking to NF-κB substrates

The inhibitor of κB (IκB) kinase (IKK) is a central regulator of NF-κB signaling. All IKK complexes contain hetero- or homodimers of the catalytic IKKβ and/or IKKα subunits. Here, we identify a YDDΦxΦ motif, which is conserved in substrates of canonical (IκBα, IκBβ) and alternative (p100) NF-κB path...

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Veröffentlicht in:	Nature communications Jg. 15; H. 1; S. 7692 - 19
Hauptverfasser:	Li, Changqing, Moro, Stefano, Shostak, Kateryna, O’Reilly, Francis J., Donzeau, Mariel, Graziadei, Andrea, McEwen, Alastair G., Desplancq, Dominique, Poussin-Courmontagne, Pierre, Bachelart, Thomas, Fiskin, Mert, Berrodier, Nicolas, Pichard, Simon, Brillet, Karl, Orfanoudakis, Georges, Poterszman, Arnaud, Torbeev, Vladimir, Rappsilber, Juri, Davey, Norman E., Chariot, Alain, Zanier, Katia
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	London Nature Publishing Group UK 03.09.2024 Nature Publishing Group Springer Science and Business Media LLC Nature Portfolio
Schlagworte:	101/58 14 38 631/250/516/1909 631/45/275 631/535/1266 82/80 82/83 96 96/35 96/95 Amino Acid Motifs Biochemistry, biophysics & molecular biology Biochimie, biophysique & biologie moléculaire Dimerization Dimers Docking Enzyme inhibitors Gene expression Grooves HEK293 Cells Humanities and Social Sciences Humans I-kappa B Kinase I-kappa B Kinase - chemistry I-kappa B Kinase - genetics I-kappa B Kinase - metabolism IKK protein Kinases Life Sciences Molecular Docking Simulation Molecular modelling multidisciplinary NF-kappa B NF-kappa B - metabolism NF-KappaB Inhibitor alpha NF-KappaB Inhibitor alpha - genetics NF-KappaB Inhibitor alpha - metabolism NF-κB protein Phosphorylation Protein Binding Protein Multimerization Science Science (multidisciplinary) Sciences du vivant Signal Transduction Substrate inhibition Substrate Specificity Substrates Tyrosine
ISSN:	2041-1723, 2041-1723
Online-Zugang:	Volltext
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