Cancer stem cells and their niche in cancer progression and therapy

High recurrence and metastasis rates and poor prognoses are the major challenges of current cancer therapy. Mounting evidence suggests that cancer stem cells (CSCs) play an important role in cancer development, chemoradiotherapy resistance, recurrence, and metastasis. Therefore, targeted CSC therapy...

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Published in:Cancer cell international Vol. 23; no. 1; pp. 1 - 12
Main Authors: Liu, Qiuping, Guo, Zongliang, Li, Guoyin, Zhang, Yunxia, Liu, Xiaomeng, Li, Bing, Wang, Jinping, Li, Xiaoyan
Format: Journal Article
Language:English
Published: London BioMed Central 01.12.2023
Springer Nature B.V
BMC
Subjects:
Angiogenesis
Biomedical and Life Sciences
Biomedicine
Brain cancer
Cancer Research
cancer stem cells
Cancer therapies
Cell Biology
Cellular components
Chemoradiotherapy
Chemotherapy
Collagen
CSC niche
Cytokines
Extracellular matrix
Growth factors
Hyaluronic acid
Hypoxia
Liver cancer
Macrophages
Mesenchymal stem cells
Metastases
Metastasis
Prostate
Radiation therapy
Review
Roles
Stem cells
Stromal cells
Therapeutic strategies
Tumor microenvironment
Tumors
Cellular components
Extracellular matrix
cancer stem cells
CSC niche
Therapeutic strategies
ISSN:1475-2867, 1475-2867
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Abstract High recurrence and metastasis rates and poor prognoses are the major challenges of current cancer therapy. Mounting evidence suggests that cancer stem cells (CSCs) play an important role in cancer development, chemoradiotherapy resistance, recurrence, and metastasis. Therefore, targeted CSC therapy has become a new strategy for solving the problems of cancer metastasis and recurrence. Since the properties of CSCs are regulated by the specific tumour microenvironment, the so-called CSC niche, which targets crosstalk between CSCs and their niches, is vital in our pursuit of new therapeutic opportunities to prevent cancer from recurring. In this review, we aim to highlight the factors within the CSC niche that have important roles in regulating CSC properties, including the extracellular matrix (ECM), stromal cells (e.g., associated macrophages (TAMs), cancer-associated fibroblasts (CAFs), and mesenchymal stem cells (MSCs)), and physiological changes (e.g., inflammation, hypoxia, and angiogenesis). We also discuss recent progress regarding therapies targeting CSCs and their niche to elucidate developments of more effective therapeutic strategies to eliminate cancer.
AbstractList Abstract High recurrence and metastasis rates and poor prognoses are the major challenges of current cancer therapy. Mounting evidence suggests that cancer stem cells (CSCs) play an important role in cancer development, chemoradiotherapy resistance, recurrence, and metastasis. Therefore, targeted CSC therapy has become a new strategy for solving the problems of cancer metastasis and recurrence. Since the properties of CSCs are regulated by the specific tumour microenvironment, the so-called CSC niche, which targets crosstalk between CSCs and their niches, is vital in our pursuit of new therapeutic opportunities to prevent cancer from recurring. In this review, we aim to highlight the factors within the CSC niche that have important roles in regulating CSC properties, including the extracellular matrix (ECM), stromal cells (e.g., associated macrophages (TAMs), cancer-associated fibroblasts (CAFs), and mesenchymal stem cells (MSCs)), and physiological changes (e.g., inflammation, hypoxia, and angiogenesis). We also discuss recent progress regarding therapies targeting CSCs and their niche to elucidate developments of more effective therapeutic strategies to eliminate cancer.
High recurrence and metastasis rates and poor prognoses are the major challenges of current cancer therapy. Mounting evidence suggests that cancer stem cells (CSCs) play an important role in cancer development, chemoradiotherapy resistance, recurrence, and metastasis. Therefore, targeted CSC therapy has become a new strategy for solving the problems of cancer metastasis and recurrence. Since the properties of CSCs are regulated by the specific tumour microenvironment, the so-called CSC niche, which targets crosstalk between CSCs and their niches, is vital in our pursuit of new therapeutic opportunities to prevent cancer from recurring. In this review, we aim to highlight the factors within the CSC niche that have important roles in regulating CSC properties, including the extracellular matrix (ECM), stromal cells (e.g., associated macrophages (TAMs), cancer-associated fibroblasts (CAFs), and mesenchymal stem cells (MSCs)), and physiological changes (e.g., inflammation, hypoxia, and angiogenesis). We also discuss recent progress regarding therapies targeting CSCs and their niche to elucidate developments of more effective therapeutic strategies to eliminate cancer.
High recurrence and metastasis rates and poor prognoses are the major challenges of current cancer therapy. Mounting evidence suggests that cancer stem cells (CSCs) play an important role in cancer development, chemoradiotherapy resistance, recurrence, and metastasis. Therefore, targeted CSC therapy has become a new strategy for solving the problems of cancer metastasis and recurrence. Since the properties of CSCs are regulated by the specific tumour microenvironment, the so-called CSC niche, which targets crosstalk between CSCs and their niches, is vital in our pursuit of new therapeutic opportunities to prevent cancer from recurring. In this review, we aim to highlight the factors within the CSC niche that have important roles in regulating CSC properties, including the extracellular matrix (ECM), stromal cells (e.g., associated macrophages (TAMs), cancer-associated fibroblasts (CAFs), and mesenchymal stem cells (MSCs)), and physiological changes (e.g., inflammation, hypoxia, and angiogenesis). We also discuss recent progress regarding therapies targeting CSCs and their niche to elucidate developments of more effective therapeutic strategies to eliminate cancer.High recurrence and metastasis rates and poor prognoses are the major challenges of current cancer therapy. Mounting evidence suggests that cancer stem cells (CSCs) play an important role in cancer development, chemoradiotherapy resistance, recurrence, and metastasis. Therefore, targeted CSC therapy has become a new strategy for solving the problems of cancer metastasis and recurrence. Since the properties of CSCs are regulated by the specific tumour microenvironment, the so-called CSC niche, which targets crosstalk between CSCs and their niches, is vital in our pursuit of new therapeutic opportunities to prevent cancer from recurring. In this review, we aim to highlight the factors within the CSC niche that have important roles in regulating CSC properties, including the extracellular matrix (ECM), stromal cells (e.g., associated macrophages (TAMs), cancer-associated fibroblasts (CAFs), and mesenchymal stem cells (MSCs)), and physiological changes (e.g., inflammation, hypoxia, and angiogenesis). We also discuss recent progress regarding therapies targeting CSCs and their niche to elucidate developments of more effective therapeutic strategies to eliminate cancer.
ArticleNumber 305
Author Guo, Zongliang
Zhang, Yunxia
Wang, Jinping
Li, Guoyin
Liu, Xiaomeng
Liu, Qiuping
Li, Bing
Li, Xiaoyan
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  organization: Department of General Surgery, Shanxi Province Cancer Hospital, Affiliated of Shanxi Medical University
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  fullname: Li, Guoyin
  organization: Institute of Translational Medicine, College of Life Science and Agronomy, Zhoukou Normal University
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  organization: Institute of Translational Medicine, College of Life Science and Agronomy, Zhoukou Normal University
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  email: jpwang06@126.com
  organization: Department of Ultrasound, Shanxi Province People’s Hospital
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  givenname: Xiaoyan
  surname: Li
  fullname: Li, Xiaoyan
  email: xiaoyanli5959@163.com
  organization: Department of blood transfusion, Shanxi Provincial People’s Hospital, Department of central laboratory, Shanxi Provincial People’s Hospital
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Issue 1
Keywords Cellular components
Extracellular matrix
cancer stem cells
CSC niche
Therapeutic strategies
Language English
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Snippet High recurrence and metastasis rates and poor prognoses are the major challenges of current cancer therapy. Mounting evidence suggests that cancer stem cells...
Abstract High recurrence and metastasis rates and poor prognoses are the major challenges of current cancer therapy. Mounting evidence suggests that cancer...
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SubjectTerms Angiogenesis
Biomedical and Life Sciences
Biomedicine
Brain cancer
Cancer Research
cancer stem cells
Cancer therapies
Cell Biology
Cellular components
Chemoradiotherapy
Chemotherapy
Collagen
CSC niche
Cytokines
Extracellular matrix
Growth factors
Hyaluronic acid
Hypoxia
Liver cancer
Macrophages
Mesenchymal stem cells
Metastases
Metastasis
Prostate
Radiation therapy
Review
Roles
Stem cells
Stromal cells
Therapeutic strategies
Tumor microenvironment
Tumors
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Title Cancer stem cells and their niche in cancer progression and therapy
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