Aliskiren and the calcium channel blocker amlodipine combination as an initial treatment strategy for hypertension control (ACCELERATE): a randomised, parallel-group trial

Short-term studies have suggested that the use of initial combination therapy for the control of blood pressure improves early effectiveness. We tested whether a combination of aliskiren and amlodipine is superior to each monotherapy in early control of blood pressure without excess of adverse event...

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Bibliographic Details
Published in:	The Lancet (British edition) Vol. 377; no. 9762; pp. 312 - 320
Main Authors:	Brown, Morris J, McInnes, Gordon T, Papst, Cheraz Cherif, Zhang, Jack, MacDonald, Thomas M
Format:	Journal Article
Language:	English
Published:	Kidlington Elsevier Ltd 22.01.2011 Elsevier Elsevier Limited
Subjects:	Amides - therapeutic use Amlodipine - therapeutic use Antihypertensive Agents - therapeutic use Arterial hypertension. Arterial hypotension Biological and medical sciences Blood and lymphatic vessels Blood pressure Calcium Channel Blockers - therapeutic use Calcium channels Cardiology. Vascular system Clinical trials Diastole - drug effects Double-Blind Method Drug therapy Drug Therapy, Combination Edema Female Fumarates - therapeutic use General aspects Humans Hypertension Hypertension - drug therapy Hypotension Internal Medicine Male Medical sciences Middle Aged Mortality patients Systole - drug effects systolic blood pressure therapeutics Antianginal agent Hypertension Enzyme Calcium antagonist Enzyme inhibitor Aliskiren Check Non peptide compound Cardiovascular disease Medicine Peptidases Randomization Renin Treatment Surveillance Amlodipine Hydrolases Antihypertensive agent Clinical trial Strategy Aspartic endopeptidases Dihydropyridine derivatives
ISSN:	0140-6736, 1474-547X, 1474-547X
Online Access:	Get full text
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