Model-based translation of DNA damage signaling dynamics across cell types

Interindividual variability in DNA damage response (DDR) dynamics may evoke differences in susceptibility to cancer. However, pathway dynamics are often studied in cell lines as alternative to primary cells, disregarding variability. To compare DDR dynamics in the cell line HepG2 with primary human...

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Bibliographic Details
Published in:	PLoS computational biology Vol. 18; no. 7; p. e1010264
Main Authors:	Heldring, Muriel M., Wijaya, Lukas S., Niemeijer, Marije, Yang, Huan, Lakhal, Talel, Le Dévédec, Sylvia E., van de Water, Bob, Beltman, Joost B.
Format:	Journal Article
Language:	English
Published:	San Francisco Public Library of Science 08.07.2022 Public Library of Science (PLoS)
Subjects:	Antibodies Biology and life sciences BTG2 protein Cell cycle Cells Cellular signal transduction Computer applications Correlation Cyclin-dependent kinase inhibitor p21 Damage Deoxyribonucleic acid DNA DNA damage DNA repair Dynamic models Dynamics Extrapolation Gene expression Genetic aspects Genetic translation Hepatocytes Kinases Liver cancer MDM2 protein Medicine and Health Sciences Metabolism p53 Protein Physiological aspects Protein expression Proteins Research and Analysis Methods Translation Netherlands
ISSN:	1553-7358, 1553-734X, 1553-7358
Online Access:	Get full text
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