Cellular changes in the postmortem hippocampus in major depression

Imaging studies report that hippocampal volume is decreased in major depressive disorder (MDD). A cellular basis for reduced hippocampal volume in MDD has not been identified. Sections of right hippocampus were collected in 19 subjects with MDD and 21 normal control subjects. The density of pyramida...

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Vydáno v:Biological psychiatry (1969) Ročník 56; číslo 9; s. 640 - 650
Hlavní autoři: Stockmeier, Craig A., Mahajan, Gouri J., Konick, Lisa C., Overholser, James C., Jurjus, George J., Meltzer, Herbert Y., Uylings, Harry B.M., Friedman, Lee, Rajkowska, Grazyna
Médium: Journal Article
Jazyk:angličtina
Vydáno: New York, NY Elsevier Inc 01.11.2004
Elsevier Science
Témata:
Adult
Adult and adolescent clinical studies
Aged
Aged, 80 and over
Anatomy
Biological and medical sciences
Case-Control Studies
Cell Count - methods
Cell Size
Central nervous system
Depression
Depressive Disorder, Major - pathology
Female
Fundamental and applied biological sciences. Psychology
glia
hippocampus
Hippocampus - pathology
Humans
Imaging, Three-Dimensional - methods
Male
Medical sciences
Middle Aged
Mood disorders
Neuroglia - pathology
Neurons - pathology
Postmortem Changes
Psychology. Psychoanalysis. Psychiatry
Psychopathology. Psychiatry
pyramidal neurons
Staining and Labeling - methods
Time Factors
Vertebrates: nervous system and sense organs
pyramidal neurons
Depression
hippocampus
glia
Mood disorder
Human
Healthy subject
Granule neuron
Central nervous system
Postmortem
Pyramidal neuron
Comparative study
Hippocampus
Encephalon
Cell density
ISSN:0006-3223, 1873-2402
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Popis
Shrnutí:Imaging studies report that hippocampal volume is decreased in major depressive disorder (MDD). A cellular basis for reduced hippocampal volume in MDD has not been identified. Sections of right hippocampus were collected in 19 subjects with MDD and 21 normal control subjects. The density of pyramidal neurons, dentate granule cell neurons, glia, and the size of the neuronal somal area were measured in systematic, randomly placed three-dimensional optical disector counting boxes. In MDD, cryostat-cut hippocampal sections shrink in depth a significant 18% greater amount than in control subjects. The density of granule cells and glia in the dentate gyrus and pyramidal neurons and glia in all cornv ammonis (CA)/hippocampal subfields is significantly increased by 30% –35% in MDD. The average soma size of pyramidal neurons is significantly decreased in MDD. In MDD, the packing density of glia, pyramidal neurons, and granule cell neurons is significantly increased in all hippocampal subfields and the dentate gyrus, and pyramidal neuron soma size is significantly decreased as well. It is suggested that a significant reduction in neuropil in MDD may account for decreased hippocampal volume detected by neuroimaging. In addition, differential shrinkage of frozen sections of the hippocampus suggests differential water content in hippocampus in MDD.
Bibliografie:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-1
content type line 23
ISSN:0006-3223
1873-2402
DOI:10.1016/j.biopsych.2004.08.022