The miR-200 family inhibits epithelial-mesenchymal transition and cancer cell migration by direct targeting of E-cadherin transcriptional repressors ZEB1 and ZEB2

MicroRNAs are small non-coding RNA molecules that can regulate gene expression by interacting with multiple mRNAs and inducing either translation suppression or degradation of mRNA. Recently, several miRNAs were identified as either promoters or suppressors of metastasis. However, it is unclear in w...

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Veröffentlicht in:	The Journal of biological chemistry Jg. 283; H. 22; S. 14910
Hauptverfasser:	Korpal, Manav, Lee, Esther S, Hu, Guohong, Kang, Yibin
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	United States 30.05.2008
Schlagworte:	Animals Cadherins - biosynthesis Cadherins - genetics Cell Movement - drug effects Cell Movement - genetics Epithelial Cells - metabolism Gene Expression Regulation, Neoplastic - drug effects Gene Expression Regulation, Neoplastic - genetics Genome, Human - genetics HeLa Cells Homeodomain Proteins - biosynthesis Homeodomain Proteins - genetics Humans Kruppel-Like Transcription Factors - biosynthesis Kruppel-Like Transcription Factors - genetics Mice MicroRNAs - biosynthesis MicroRNAs - genetics Multigene Family - genetics Neoplasm Metastasis Neoplasms - genetics Neoplasms - metabolism Repressor Proteins - biosynthesis Repressor Proteins - genetics Transcription Factors - biosynthesis Transcription Factors - genetics Transforming Growth Factor beta - pharmacology Zinc Finger E-box Binding Homeobox 2 Zinc Finger E-box-Binding Homeobox 1
ISSN:	0021-9258
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