Potential Role of Curcumin and Its Nanoformulations to Treat Various Types of Cancers

Cancer is a major burden of disease globally. Each year, tens of millions of people are diagnosed with cancer worldwide, and more than half of the patients eventually die from it. Significant advances have been noticed in cancer treatment, but the mortality and incidence rates of cancers are still h...

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Veröffentlicht in:	Biomolecules (Basel, Switzerland) Jg. 11; H. 3; S. 392
Hauptverfasser:	Kabir, Md. Tanvir, Rahman, Md. Habibur, Akter, Rokeya, Behl, Tapan, Kaushik, Deepak, Mittal, Vineet, Pandey, Parijat, Akhtar, Muhammad Furqan, Saleem, Ammara, Albadrani, Ghadeer M., Kamel, Mohamed, Khalifa, Shaden A.M., El-Seedi, Hesham R., Abdel-Daim, Mohamed M.
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	Switzerland MDPI AG 07.03.2021 MDPI
Schlagworte:	Animal models Anti-inflammatory agents anticancer Antioxidants Antitumor activity Apoptosis Autophagy Bioavailability Biocompatibility Breast Cancer Cancer therapies Cell adhesion & migration Cell cycle Cell growth cellular mechanisms Collagen Colorectal cancer Curcuma longa Curcumin Cyclooxygenase-2 Drug delivery Drug delivery systems Epidermal growth factor Head and neck Inflammation Kinases Lymphoma MAP kinase mechanism of action Metastasis nanoformulations Nanomaterials NF-κB protein Ovarian cancer Pancreas Peptides Phosphorylation Prostate cancer Protein kinase Quantum dots Review Solubility Stat3 protein Transcription Transcription factors Tumor cell lines Tumor necrosis factor-TNF Tumor necrosis factor-α Tumors mechanism of action cellular mechanisms Curcuma longa anticancer nanoformulations curcumin
ISSN:	2218-273X, 2218-273X
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Abstract	Cancer is a major burden of disease globally. Each year, tens of millions of people are diagnosed with cancer worldwide, and more than half of the patients eventually die from it. Significant advances have been noticed in cancer treatment, but the mortality and incidence rates of cancers are still high. Thus, there is a growing research interest in developing more effective and less toxic cancer treatment approaches. Curcumin (CUR), the major active component of turmeric (Curcuma longa L.), has gained great research interest as an antioxidant, anticancer, and anti-inflammatory agent. This natural compound shows its anticancer effect through several pathways including interfering with multiple cellular mechanisms and inhibiting/inducing the generation of multiple cytokines, enzymes, or growth factors including IκB kinase β (IκKβ), tumor necrosis factor-alpha (TNF-α), signal transducer, and activator of transcription 3 (STAT3), cyclooxygenase II (COX-2), protein kinase D1 (PKD1), nuclear factor-kappa B (NF-κB), epidermal growth factor, and mitogen-activated protein kinase (MAPK). Interestingly, the anticancer activity of CUR has been limited primarily due to its poor water solubility, which can lead to low chemical stability, low oral bioavailability, and low cellular uptake. Delivering drugs at a controlled rate, slow delivery, and targeted delivery are other very attractive methods and have been pursued vigorously. Multiple CUR nanoformulations have also been developed so far to ameliorate solubility and bioavailability of CUR and to provide protection to CUR against hydrolysis inactivation. In this review, we have summarized the anticancer activity of CUR against several cancers, for example, gastrointestinal, head and neck, brain, pancreatic, colorectal, breast, and prostate cancers. In addition, we have also focused on the findings obtained from multiple experimental and clinical studies regarding the anticancer effect of CUR in animal models, human subjects, and cancer cell lines.
AbstractList	Cancer is a major burden of disease globally. Each year, tens of millions of people are diagnosed with cancer worldwide, and more than half of the patients eventually die from it. Significant advances have been noticed in cancer treatment, but the mortality and incidence rates of cancers are still high. Thus, there is a growing research interest in developing more effective and less toxic cancer treatment approaches. Curcumin (CUR), the major active component of turmeric (Curcuma longa L.), has gained great research interest as an antioxidant, anticancer, and anti-inflammatory agent. This natural compound shows its anticancer effect through several pathways including interfering with multiple cellular mechanisms and inhibiting/inducing the generation of multiple cytokines, enzymes, or growth factors including IκB kinase β (IκKβ), tumor necrosis factor-alpha (TNF-α), signal transducer, and activator of transcription 3 (STAT3), cyclooxygenase II (COX-2), protein kinase D1 (PKD1), nuclear factor-kappa B (NF-κB), epidermal growth factor, and mitogen-activated protein kinase (MAPK). Interestingly, the anticancer activity of CUR has been limited primarily due to its poor water solubility, which can lead to low chemical stability, low oral bioavailability, and low cellular uptake. Delivering drugs at a controlled rate, slow delivery, and targeted delivery are other very attractive methods and have been pursued vigorously. Multiple CUR nanoformulations have also been developed so far to ameliorate solubility and bioavailability of CUR and to provide protection to CUR against hydrolysis inactivation. In this review, we have summarized the anticancer activity of CUR against several cancers, for example, gastrointestinal, head and neck, brain, pancreatic, colorectal, breast, and prostate cancers. In addition, we have also focused on the findings obtained from multiple experimental and clinical studies regarding the anticancer effect of CUR in animal models, human subjects, and cancer cell lines.Cancer is a major burden of disease globally. Each year, tens of millions of people are diagnosed with cancer worldwide, and more than half of the patients eventually die from it. Significant advances have been noticed in cancer treatment, but the mortality and incidence rates of cancers are still high. Thus, there is a growing research interest in developing more effective and less toxic cancer treatment approaches. Curcumin (CUR), the major active component of turmeric (Curcuma longa L.), has gained great research interest as an antioxidant, anticancer, and anti-inflammatory agent. This natural compound shows its anticancer effect through several pathways including interfering with multiple cellular mechanisms and inhibiting/inducing the generation of multiple cytokines, enzymes, or growth factors including IκB kinase β (IκKβ), tumor necrosis factor-alpha (TNF-α), signal transducer, and activator of transcription 3 (STAT3), cyclooxygenase II (COX-2), protein kinase D1 (PKD1), nuclear factor-kappa B (NF-κB), epidermal growth factor, and mitogen-activated protein kinase (MAPK). Interestingly, the anticancer activity of CUR has been limited primarily due to its poor water solubility, which can lead to low chemical stability, low oral bioavailability, and low cellular uptake. Delivering drugs at a controlled rate, slow delivery, and targeted delivery are other very attractive methods and have been pursued vigorously. Multiple CUR nanoformulations have also been developed so far to ameliorate solubility and bioavailability of CUR and to provide protection to CUR against hydrolysis inactivation. In this review, we have summarized the anticancer activity of CUR against several cancers, for example, gastrointestinal, head and neck, brain, pancreatic, colorectal, breast, and prostate cancers. In addition, we have also focused on the findings obtained from multiple experimental and clinical studies regarding the anticancer effect of CUR in animal models, human subjects, and cancer cell lines. Cancer is a major burden of disease globally. Each year, tens of millions of people are diagnosed with cancer worldwide, and more than half of the patients eventually die from it. Significant advances have been noticed in cancer treatment, but the mortality and incidence rates of cancers are still high. Thus, there is a growing research interest in developing more effective and less toxic cancer treatment approaches. Curcumin (CUR), the major active component of turmeric (Curcuma longa L.), has gained great research interest as an antioxidant, anticancer, and anti-inflammatory agent. This natural compound shows its anticancer effect through several pathways including interfering with multiple cellular mechanisms and inhibiting/inducing the generation of multiple cytokines, enzymes, or growth factors including IκB kinase β (IκKβ), tumor necrosis factor-alpha (TNF-α), signal transducer, and activator of transcription 3 (STAT3), cyclooxygenase II (COX-2), protein kinase D1 (PKD1), nuclear factor-kappa B (NF-κB), epidermal growth factor, and mitogen-activated protein kinase (MAPK). Interestingly, the anticancer activity of CUR has been limited primarily due to its poor water solubility, which can lead to low chemical stability, low oral bioavailability, and low cellular uptake. Delivering drugs at a controlled rate, slow delivery, and targeted delivery are other very attractive methods and have been pursued vigorously. Multiple CUR nanoformulations have also been developed so far to ameliorate solubility and bioavailability of CUR and to provide protection to CUR against hydrolysis inactivation. In this review, we have summarized the anticancer activity of CUR against several cancers, for example, gastrointestinal, head and neck, brain, pancreatic, colorectal, breast, and prostate cancers. In addition, we have also focused on the findings obtained from multiple experimental and clinical studies regarding the anticancer effect of CUR in animal models, human subjects, and cancer cell lines. Cancer is a major burden of disease globally. Each year, tens of millions of people are diagnosed with cancer worldwide, and more than half of the patients eventually die from it. Significant advances have been noticed in cancer treatment, but the mortality and incidence rates of cancers are still high. Thus, there is a growing research interest in developing more effective and less toxic cancer treatment approaches. Curcumin (CUR), the major active component of turmeric (Curcuma longa L.), has gained great research interest as an antioxidant, anticancer, and anti-inflammatory agent. This natural compound shows its anticancer effect through several pathways including interfering with multiple cellular mechanisms and inhibiting/inducing the generation of multiple cytokines, enzymes, or growth factors including I kappa B kinase beta (I kappa K beta), tumor necrosis factor-alpha (TNF-alpha), signal transducer, and activator of transcription 3 (STAT3), cyclooxygenase II (COX-2), protein kinase D1 (PKD1), nuclear factor-kappa B (NF-kappa B), epidermal growth factor, and mitogen-activated protein kinase (MAPK). Interestingly, the anticancer activity of CUR has been limited primarily due to its poor water solubility, which can lead to low chemical stability, low oral bioavailability, and low cellular uptake. Delivering drugs at a controlled rate, slow delivery, and targeted delivery are other very attractive methods and have been pursued vigorously. Multiple CUR nanoformulations have also been developed so far to ameliorate solubility and bioavailability of CUR and to provide protection to CUR against hydrolysis inactivation. In this review, we have summarized the anticancer activity of CUR against several cancers, for example, gastrointestinal, head and neck, brain, pancreatic, colorectal, breast, and prostate cancers. In addition, we have also focused on the findings obtained from multiple experimental and clinical studies regarding the anticancer effect of CUR in animal models, human subjects, and cancer cell lines. Cancer is a major burden of disease globally. Each year, tens of millions of people are diagnosed with cancer worldwide, and more than half of the patients eventually die from it. Significant advances have been noticed in cancer treatment, but the mortality and incidence rates of cancers are still high. Thus, there is a growing research interest in developing more effective and less toxic cancer treatment approaches. Curcumin (CUR), the major active component of turmeric ( L.), has gained great research interest as an antioxidant, anticancer, and anti-inflammatory agent. This natural compound shows its anticancer effect through several pathways including interfering with multiple cellular mechanisms and inhibiting/inducing the generation of multiple cytokines, enzymes, or growth factors including IκB kinase β (IκKβ), tumor necrosis factor-alpha (TNF-α), signal transducer, and activator of transcription 3 (STAT3), cyclooxygenase II (COX-2), protein kinase D1 (PKD1), nuclear factor-kappa B (NF-κB), epidermal growth factor, and mitogen-activated protein kinase (MAPK). Interestingly, the anticancer activity of CUR has been limited primarily due to its poor water solubility, which can lead to low chemical stability, low oral bioavailability, and low cellular uptake. Delivering drugs at a controlled rate, slow delivery, and targeted delivery are other very attractive methods and have been pursued vigorously. Multiple CUR nanoformulations have also been developed so far to ameliorate solubility and bioavailability of CUR and to provide protection to CUR against hydrolysis inactivation. In this review, we have summarized the anticancer activity of CUR against several cancers, for example, gastrointestinal, head and neck, brain, pancreatic, colorectal, breast, and prostate cancers. In addition, we have also focused on the findings obtained from multiple experimental and clinical studies regarding the anticancer effect of CUR in animal models, human subjects, and cancer cell lines.
Author	Saleem, Ammara Behl, Tapan El-Seedi, Hesham R. Akter, Rokeya Akhtar, Muhammad Furqan Kaushik, Deepak Rahman, Md. Habibur Mittal, Vineet Albadrani, Ghadeer M. Kamel, Mohamed Pandey, Parijat Kabir, Md. Tanvir Abdel-Daim, Mohamed M. Khalifa, Shaden A.M.
AuthorAffiliation	11 Department of Molecular Biosciences, The Wenner-Gren Institute, Stockholm University, S-10691 Stockholm, Sweden 13 International Research Center for Food Nutrition and Safety, Jiangsu University, Zhenjiang 212013, China 6 Shri Baba Mastnath Institute of Pharmaceutical Sciences and Research, Baba Mastnath University, Rohtak 124001, India; parijatpandey98@gmail.com 8 Department of Pharmacology, Faculty of Pharmaceutical Sciences, Government College University Faisalabad, Faisalabad 38000, Pakistan; amarafurqan786@hotmail.com 9 Department of Biology, College of Science, Princess Nourah bint Abdulrahman University, Riyadh 11474, Saudi Arabia; gmalbadrani@pnu.edu.sa 7 Riphah Institute of Pharmaceutical Sciences, Lahore Campus, Riphah International University, Lahore 54000, Pakistan; furqan.pharmacist@gmail.com 10 Department of Medicine and Infectious Diseases, Faculty of Veterinary Medicine, Cairo University, Giza 12211, Egypt; m_salah@cu.edu.eg 3 Department of Pharmacy, Jagannath University, S
AuthorAffiliation_xml	– name: 6 Shri Baba Mastnath Institute of Pharmaceutical Sciences and Research, Baba Mastnath University, Rohtak 124001, India; parijatpandey98@gmail.com – name: 12 Pharmacognosy Group, Department of Medicinal Chemistry, Uppsala University, Biomedical Centre, Box 574, 751 23 Uppsala, Sweden; hesham.el-seedi@farmbio.uu.se – name: 8 Department of Pharmacology, Faculty of Pharmaceutical Sciences, Government College University Faisalabad, Faisalabad 38000, Pakistan; amarafurqan786@hotmail.com – name: 1 Department of Pharmacy, Brac University, 66 Mohakhali, Dhaka 1212, Bangladesh; tanvir_kbr@yahoo.com – name: 5 Department of Pharmaceutical Sciences, Maharshi Dayanand University, Rohtak 124001, India; deepkaushik1977@gmail.com (D.K.); vineetmittalmdu@gmail.com (V.M.) – name: 2 Department of Pharmacy, Southeast University, Banani, Dhaka 1213, Bangladesh – name: 3 Department of Pharmacy, Jagannath University, Sadarghat, Dhaka 1100, Bangladesh; rokeyahabib94@gmail.com – name: 11 Department of Molecular Biosciences, The Wenner-Gren Institute, Stockholm University, S-10691 Stockholm, Sweden – name: 10 Department of Medicine and Infectious Diseases, Faculty of Veterinary Medicine, Cairo University, Giza 12211, Egypt; m_salah@cu.edu.eg – name: 13 International Research Center for Food Nutrition and Safety, Jiangsu University, Zhenjiang 212013, China – name: 14 Department of Chemistry, Faculty of Science, Menoufia University, Shebin El-Kom 32512, Egypt – name: 9 Department of Biology, College of Science, Princess Nourah bint Abdulrahman University, Riyadh 11474, Saudi Arabia; gmalbadrani@pnu.edu.sa – name: 4 Chitkara College of Pharmacy, Chitkara University, Punjab 140401, India; tapanbehl31@gmail.com – name: 7 Riphah Institute of Pharmaceutical Sciences, Lahore Campus, Riphah International University, Lahore 54000, Pakistan; furqan.pharmacist@gmail.com – name: 15 Pharmacology Department, Faculty of Veterinary Medicine, Suez Canal University, Ismailia 41522, Egypt
Author_xml	– sequence: 1 givenname: Md. Tanvir orcidid: 0000-0002-6078-8587 surname: Kabir fullname: Kabir, Md. Tanvir – sequence: 2 givenname: Md. Habibur orcidid: 0000-0001-6099-5693 surname: Rahman fullname: Rahman, Md. Habibur – sequence: 3 givenname: Rokeya surname: Akter fullname: Akter, Rokeya – sequence: 4 givenname: Tapan surname: Behl fullname: Behl, Tapan – sequence: 5 givenname: Deepak orcidid: 0000-0002-3286-196X surname: Kaushik fullname: Kaushik, Deepak – sequence: 6 givenname: Vineet orcidid: 0000-0002-0980-5628 surname: Mittal fullname: Mittal, Vineet – sequence: 7 givenname: Parijat orcidid: 0000-0003-2298-3645 surname: Pandey fullname: Pandey, Parijat – sequence: 8 givenname: Muhammad Furqan orcidid: 0000-0002-2407-1503 surname: Akhtar fullname: Akhtar, Muhammad Furqan – sequence: 9 givenname: Ammara orcidid: 0000-0002-2478-7800 surname: Saleem fullname: Saleem, Ammara – sequence: 10 givenname: Ghadeer M. surname: Albadrani fullname: Albadrani, Ghadeer M. – sequence: 11 givenname: Mohamed surname: Kamel fullname: Kamel, Mohamed – sequence: 12 givenname: Shaden A.M. surname: Khalifa fullname: Khalifa, Shaden A.M. – sequence: 13 givenname: Hesham R. surname: El-Seedi fullname: El-Seedi, Hesham R. – sequence: 14 givenname: Mohamed M. orcidid: 0000-0002-4341-2713 surname: Abdel-Daim fullname: Abdel-Daim, Mohamed M.
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SubjectTerms	Animal models Anti-inflammatory agents anticancer Antioxidants Antitumor activity Apoptosis Autophagy Bioavailability Biocompatibility Breast Cancer Cancer therapies Cell adhesion & migration Cell cycle Cell growth cellular mechanisms Collagen Colorectal cancer Curcuma longa Curcumin Cyclooxygenase-2 Drug delivery Drug delivery systems Epidermal growth factor Head and neck Inflammation Kinases Lymphoma MAP kinase mechanism of action Metastasis nanoformulations Nanomaterials NF-κB protein Ovarian cancer Pancreas Peptides Phosphorylation Prostate cancer Protein kinase Quantum dots Review Solubility Stat3 protein Transcription Transcription factors Tumor cell lines Tumor necrosis factor-TNF Tumor necrosis factor-α Tumors
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Title	Potential Role of Curcumin and Its Nanoformulations to Treat Various Types of Cancers
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