A core-shell Au@Cu2-xSe heterogeneous metal nanocomposite for photoacoustic and computed tomography dual-imaging-guided photothermal boosted chemodynamic therapy

Chemodynamic therapy (CDT) has aroused extensive attention for conquering cancers because of its high specificity and low invasiveness. Quick generation of hydroxyl radicals ( · OH) during CDT could induce more irreparable damage to cancer cells. The generation rate of · OH could be magnified via th...

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Bibliographic Details
Published in:Journal of nanobiotechnology Vol. 19; no. 1; pp. 1 - 18
Main Authors: Zhang, Le, Jiang, Chunjuan, Li, Bing, Liu, Zhengwang, Gu, Bingxin, He, Simin, Li, Panli, Sun, Yun, Song, Shaoli
Format: Journal Article
Language:English
Published: London BioMed Central 07.12.2021
BioMed Central Ltd
Springer Nature B.V
BMC
Subjects:
Analysis
Apoptosis
Biotechnology
Cancer
Care and treatment
Cell death
Chemistry
Chemistry and Materials Science
Chemodynamic therapy
Computed tomography
Copper
Core-shell metal nanoparticles
Core-shell structure
CT imaging
Deoxyribonucleic acid
Diagnosis
DNA
Efficiency
Fenton-like reaction
Free radicals
Gold
Health aspects
Heat
Hydroxyl radicals
Hyperthermia
Invasiveness
Lasers
Medical imaging
Methods
Molecular Medicine
Nanocomposites
Nanomaterials
Nanoparticles
Nanotechnology
Photochemotherapy
Photothermal conversion
Photothermal therapy
Physiology
Risk factors
Spectrum analysis
Surface plasmon resonance
Therapy
Thermal energy
Tomography
Tumor imaging
Tumors
China
Photothermal therapy
Fenton-like reaction
Core-shell metal nanoparticles
Chemodynamic therapy
Tumor imaging
ISSN:1477-3155, 1477-3155
Online Access:Get full text
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Summary:Chemodynamic therapy (CDT) has aroused extensive attention for conquering cancers because of its high specificity and low invasiveness. Quick generation of hydroxyl radicals ( · OH) during CDT could induce more irreparable damage to cancer cells. The generation rate of · OH could be magnified via the selection of suitable nanocatalysts or under the assistance of exogenous thermal energy from photothermal therapy (PTT). Here, we construct a kind of monodisperse core-shell Au@Cu 2-x Se heterogeneous metal nanoparticles (NPs) for PTT boosted CDT synergistic therapy. Due to the localized surface plasmon resonance (LSPR) coupling effect in the core-shell structure, the photothermal conversion efficiency of Au@Cu 2-x Se NPs is up to 56.6%. The in situ generated heat from photothermal can then accelerate the Fenton-like reaction at Cu + sites to produce abundant · OH, which will induce apoptotic cell death by attacking DNA, contributing to a heat-boosted CDT. Both in vitro and in vivo results showed that after this synergistic therapy, tumors could be remarkably suppressed. Guided by photoacoustic (PA) and computed tomography (CT) imaging, the therapeutic effects were more specified. Our results revealed that PA and CT dual-imaging-guided PTT boosted CDT synergistic therapy based on core-shell Au@Cu 2-x Se NPs is an effective cancer treatment strategy. Graphical Abstract
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ISSN:1477-3155
1477-3155
DOI:10.1186/s12951-021-01159-x