Salidroside reduces neuropathology in Alzheimer’s disease models by targeting NRF2/SIRT3 pathway

Background Neurite dystrophy is a pathologic hallmark of Alzheimer’s disease (AD). However, drug discovery targeting neurite protection in AD remains largely unexplored. Methods Aβ-induced neurite and mitochondrial damage assays were used to evaluate Aβ toxicity and the neuroprotective efficacy of a...

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Vydáno v:	Cell & bioscience Ročník 12; číslo 1; s. 1 - 18
Hlavní autoři:	Yao, Yuyuan, Ren, Zhichu, Yang, Ruihan, Mei, Yilan, Dai, Yuying, Cheng, Qian, Xu, Chong, Xu, Xiaogang, Wang, Sanying, Kim, Kyoung Mi, Noh, Ji Heon, Zhu, Jian, Zhao, Ningwei, Liu, Yong U., Mao, Genxiang, Sima, Jian
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	London BioMed Central 04.11.2022 BioMed Central Ltd Springer Nature B.V BMC
Témata:	Advertising executives Aging Alzheimer's disease Analysis Animal models Axons Biomedical and Life Sciences Cell Biology Cell culture Cognitive ability Drug development Drug discovery Dystrophy Experiments Genetic engineering Homeostasis Life Sciences Ligases Microbiology Mitochondria Mitochondrial protection Morphology Neurobiology Neurodegenerative diseases Neuroprotection NRF2 Oxidative stress Pathogenesis Pathology Peptides Proteomics SAL SIRT3 Stem Cells Surface plasmon resonance Target marketing Toxicity Transgenic mice Ubiquitin Ubiquitin-protein ligase Mitochondrial protection Alzheimer’s disease NRF2 SAL SIRT3
ISSN:	2045-3701, 2045-3701
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