Structural basis for Marburg virus VP35-mediated immune evasion mechanisms

Filoviruses, marburgvirus (MARV) and ebolavirus (EBOV), are causative agents of highly lethal hemorrhagic fever in humans. MARV and EBOV share a common genome organization but show important differences in replication complex formation, cell entry, host tropism, transcriptional regulation, and immun...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS Jg. 109; H. 50; S. 20661
Hauptverfasser:	Ramanan, Parameshwaran, Edwards, Megan R, Shabman, Reed S, Leung, Daisy W, Endlich-Frazier, Ariel C, Borek, Dominika M, Otwinowski, Zbyszek, Liu, Gai, Huh, Juyoung, Basler, Christopher F, Amarasinghe, Gaya K
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	United States 11.12.2012
Schlagworte:	Amino Acid Sequence Animals Base Sequence Crystallography, X-Ray HEK293 Cells Host-Pathogen Interactions Humans I-kappa B Kinase - antagonists & inhibitors Immunity, Innate Interferon Type I - antagonists & inhibitors Marburg Virus Disease - etiology Marburg Virus Disease - immunology Marburg Virus Disease - virology Marburgvirus - chemistry Marburgvirus - immunology Marburgvirus - pathogenicity Models, Biological Models, Molecular Molecular Sequence Data Protein Structure, Tertiary Protein-Serine-Threonine Kinases - antagonists & inhibitors RNA - chemistry RNA - genetics RNA - metabolism Sequence Homology, Amino Acid Viral Regulatory and Accessory Proteins - chemistry Viral Regulatory and Accessory Proteins - immunology Virulence - immunology
ISSN:	1091-6490, 1091-6490
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