Artificial intelligence, drug repurposing and peer review

Can traditional computational analysis and machine learning help compensate for inadequate peer review of drug-repurposing papers in the context of an infodemic?

Uloženo v:
Podrobná bibliografie
Vydáno v:Nature biotechnology Ročník 38; číslo 10; s. 1127 - 1131
Hlavní autoři: Levin, Jeremy M, Oprea, Tudor I, Davidovich, Sagie, Clozel, Thomas, Overington, John P, Vanhaelen, Quentin, Cantor, Charles R, Bischof, Evelyne, Zhavoronkov, Alex
Médium: Journal Article
Jazyk:angličtina
Vydáno: United States Nature Publishing Group 01.10.2020
Témata:
Artificial Intelligence
Computational Biology - trends
Computer applications
COVID-19 - drug therapy
Drug Repositioning - trends
Humans
Learning algorithms
Machine learning
Pandemics
Peer Review
ISSN:1087-0156, 1546-1696, 1546-1696
On-line přístup:Získat plný text
Tagy: Přidat tag
Žádné tagy, Buďte první, kdo vytvoří štítek k tomuto záznamu!
Abstract Can traditional computational analysis and machine learning help compensate for inadequate peer review of drug-repurposing papers in the context of an infodemic?
AbstractList Can traditional computational analysis and machine learning help compensate for inadequate peer review of drug-repurposing papers in the context of an infodemic?
Author Oprea, Tudor I
Zhavoronkov, Alex
Levin, Jeremy M
Overington, John P
Davidovich, Sagie
Cantor, Charles R
Vanhaelen, Quentin
Clozel, Thomas
Bischof, Evelyne
Author_xml – sequence: 1
  givenname: Jeremy M
  orcidid: 0000-0003-4692-4797
  surname: Levin
  fullname: Levin, Jeremy M
  organization: Biotechnology Innovation Organization (BIO), Washington, DC, USA
– sequence: 2
  givenname: Tudor I
  surname: Oprea
  fullname: Oprea, Tudor I
  organization: Novo Nordisk Foundation Center for Protein Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark
– sequence: 3
  givenname: Sagie
  surname: Davidovich
  fullname: Davidovich, Sagie
  organization: SparkBeyond, Netanya, Israel
– sequence: 4
  givenname: Thomas
  surname: Clozel
  fullname: Clozel, Thomas
  organization: Owkin, Paris, France
– sequence: 5
  givenname: John P
  orcidid: 0000-0002-5859-1064
  surname: Overington
  fullname: Overington, John P
  organization: Medicines Discovery Catapult, Cheshire, UK
– sequence: 6
  givenname: Quentin
  surname: Vanhaelen
  fullname: Vanhaelen, Quentin
  organization: Insilico Medicine, Hong Kong Science and Technology Park, Hong Kong, China
– sequence: 7
  givenname: Charles R
  surname: Cantor
  fullname: Cantor, Charles R
  organization: Retrotope, Inc, Los Altos, CA, USA
– sequence: 8
  givenname: Evelyne
  surname: Bischof
  fullname: Bischof, Evelyne
  email: bischofevelyne@gmail.com, bischofevelyne@gmail.com, bischofevelyne@gmail.com
  organization: Department of Advanced Biomedical Sciences, Federico II University of Naples, Naples, Italy. bischofevelyne@gmail.com
– sequence: 9
  givenname: Alex
  orcidid: 0000-0001-7067-8966
  surname: Zhavoronkov
  fullname: Zhavoronkov, Alex
  email: alex@insilico.com
  organization: Insilico Medicine, Hong Kong Science and Technology Park, Hong Kong, China. alex@insilico.com
BackLink https://www.ncbi.nlm.nih.gov/pubmed/32929264$$D View this record in MEDLINE/PubMed
BookMark eNpdkEtLxDAUhYOMOA_9AW6k4MaF1dw0SZPlMPiCATe6Lml7WzJ00pq0Pv69EceNnMW9nPtxOZwlmbneISHnQG-AZuo2cBAqTymjKZVKpp9HZAGCyxSklrO4058rCDknyxB2lFLJpTwh84zpKMkXRK_9aBtbWdMl1o3YdbZFV-F1UvupTTwOkx_6YF2bGFcnA6KP5rvFj1Ny3Jgu4Nlhrsjr_d3L5jHdPj88bdbbtJKgxlRJYYAi1WVVqkxxVMiFQFaXnCEaRQ3LGRdgkJWsMQyB5VpDzQF4iQ1kK3L1-3fw_duEYSz2NlQxqHHYT6FgnDPFlc5VRC__obt-8i6mi1Quc5lpLSJ1caCmco91MXi7N_6r-Csl-waL1mRt
CitedBy_id crossref_primary_10_3390_ijms24076788
crossref_primary_10_1016_j_dsx_2021_06_017
crossref_primary_10_1093_nar_gkac1085
crossref_primary_10_1016_j_jbi_2021_103821
crossref_primary_10_3389_fimmu_2021_658519
crossref_primary_10_3390_molecules26133800
crossref_primary_10_1002_slct_202304359
crossref_primary_10_1186_s13023_024_03095_z
crossref_primary_10_1002_ange_202204139
crossref_primary_10_3389_fphar_2023_1182465
crossref_primary_10_1016_j_drudis_2021_04_018
crossref_primary_10_1109_TCBBIO_2025_3570865
crossref_primary_10_1093_bib_bbaa378
crossref_primary_10_3389_fphar_2023_1181711
crossref_primary_10_1016_j_compbiomed_2023_106671
crossref_primary_10_1080_09537287_2023_2248947
crossref_primary_10_1007_s12010_022_03928_2
crossref_primary_10_1016_j_heliyon_2023_e14115
crossref_primary_10_1007_s44337_025_00300_1
crossref_primary_10_1093_nar_gkaa997
crossref_primary_10_3390_pharmaceutics14030567
crossref_primary_10_3390_app12168373
crossref_primary_10_1093_nar_gkaa993
crossref_primary_10_3390_ijms25094870
crossref_primary_10_1080_0361526X_2024_2428377
crossref_primary_10_1002_anie_202204139
crossref_primary_10_7717_peerj_cs_564
crossref_primary_10_3390_ijerph18178989
crossref_primary_10_1007_s10796_021_10131_x
crossref_primary_10_1371_journal_pone_0323761
crossref_primary_10_26599_NBE_2023_9290043
crossref_primary_10_1093_bib_bbad459
crossref_primary_10_1146_annurev_pharmtox_040323_040828
crossref_primary_10_3389_fphar_2022_895573
crossref_primary_10_1155_2022_4202745
ContentType Journal Article
Copyright Copyright Nature Publishing Group Oct 2020
Copyright_xml – notice: Copyright Nature Publishing Group Oct 2020
DBID CGR
CUY
CVF
ECM
EIF
NPM
3V.
7QO
7QP
7QR
7T7
7TK
7TM
7X7
7XB
88A
88E
88I
8AO
8FD
8FE
8FG
8FH
8FI
8FJ
8FK
8G5
ABJCF
ABUWG
AEUYN
AFKRA
AZQEC
BBNVY
BENPR
BGLVJ
BHPHI
C1K
CCPQU
DWQXO
FR3
FYUFA
GHDGH
GNUQQ
GUQSH
HCIFZ
K9.
L6V
LK8
M0S
M1P
M2O
M2P
M7P
M7S
MBDVC
P64
PHGZM
PHGZT
PJZUB
PKEHL
PPXIY
PQEST
PQGLB
PQQKQ
PQUKI
PRINS
PTHSS
Q9U
RC3
7X8
DOI 10.1038/s41587-020-0686-x
DatabaseName Medline
MEDLINE
MEDLINE (Ovid)
MEDLINE
MEDLINE
PubMed
ProQuest Central (Corporate)
Biotechnology Research Abstracts
Calcium & Calcified Tissue Abstracts
Chemoreception Abstracts
Industrial and Applied Microbiology Abstracts (Microbiology A)
Neurosciences Abstracts
Nucleic Acids Abstracts
Health & Medical Collection
ProQuest Central (purchase pre-March 2016)
Biology Database (Alumni Edition)
Medical Database (Alumni Edition)
Science Database (Alumni Edition)
ProQuest Pharma Collection
Technology Research Database
ProQuest SciTech Collection
ProQuest Technology Collection
ProQuest Natural Science Collection
Hospital Premium Collection
Hospital Premium Collection (Alumni Edition)
ProQuest Central (Alumni) (purchase pre-March 2016)
Research Library (Alumni Edition)
Materials Science & Engineering Collection
ProQuest Central (Alumni Edition)
ProQuest One Sustainability
ProQuest Central UK/Ireland
ProQuest Central Essentials
Biological Science Collection
ProQuest Central
Technology Collection
Natural Science Collection
Environmental Sciences and Pollution Management
ProQuest One Community College
ProQuest Central Korea
Engineering Research Database
Health Research Premium Collection
Health Research Premium Collection (Alumni)
ProQuest Central Student
Research Library Prep
SciTech Premium Collection
ProQuest Health & Medical Complete (Alumni)
ProQuest Engineering Collection
ProQuest Biological Science Collection
Health & Medical Collection (Alumni)
Medical Database
Research Library
Science Database
Biological Science Database
Engineering Database
Research Library (Corporate)
Biotechnology and BioEngineering Abstracts
ProQuest One Academic
ProQuest One Academic (New)
ProQuest Health & Medical Research Collection
ProQuest One Academic Middle East (New)
ProQuest One Health & Nursing
ProQuest One Academic Eastern Edition (DO NOT USE)
ProQuest One Applied & Life Sciences
ProQuest One Academic (retired)
ProQuest One Academic UKI Edition
ProQuest Central China
Engineering Collection
ProQuest Central Basic
Genetics Abstracts
MEDLINE - Academic
DatabaseTitle MEDLINE
Medline Complete
MEDLINE with Full Text
PubMed
MEDLINE (Ovid)
Research Library Prep
ProQuest Central Student
ProQuest Central Essentials
Nucleic Acids Abstracts
SciTech Premium Collection
ProQuest Central China
Environmental Sciences and Pollution Management
ProQuest One Applied & Life Sciences
ProQuest One Sustainability
Health Research Premium Collection
Natural Science Collection
Health & Medical Research Collection
Biological Science Collection
Chemoreception Abstracts
Industrial and Applied Microbiology Abstracts (Microbiology A)
ProQuest Central (New)
ProQuest Medical Library (Alumni)
Engineering Collection
Engineering Database
ProQuest Science Journals (Alumni Edition)
ProQuest Biological Science Collection
ProQuest One Academic Eastern Edition
ProQuest Hospital Collection
ProQuest Technology Collection
Health Research Premium Collection (Alumni)
Biological Science Database
Neurosciences Abstracts
ProQuest Hospital Collection (Alumni)
Biotechnology and BioEngineering Abstracts
ProQuest Health & Medical Complete
ProQuest One Academic UKI Edition
Engineering Research Database
ProQuest One Academic
Calcium & Calcified Tissue Abstracts
ProQuest One Academic (New)
Technology Collection
Technology Research Database
ProQuest One Academic Middle East (New)
ProQuest Health & Medical Complete (Alumni)
ProQuest Central (Alumni Edition)
ProQuest One Community College
ProQuest One Health & Nursing
Research Library (Alumni Edition)
ProQuest Natural Science Collection
ProQuest Pharma Collection
ProQuest Biology Journals (Alumni Edition)
ProQuest Central
ProQuest Health & Medical Research Collection
Genetics Abstracts
ProQuest Engineering Collection
Biotechnology Research Abstracts
Health and Medicine Complete (Alumni Edition)
ProQuest Central Korea
ProQuest Research Library
ProQuest Central Basic
ProQuest Science Journals
ProQuest SciTech Collection
ProQuest Medical Library
Materials Science & Engineering Collection
ProQuest Central (Alumni)
MEDLINE - Academic
DatabaseTitleList Research Library Prep
Database_xml – sequence: 1
  dbid: NPM
  name: PubMed
  url: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed
  sourceTypes: Index Database
– sequence: 2
  dbid: BENPR
  name: ProQuest Central
  url: https://www.proquest.com/central
  sourceTypes: Aggregation Database
DeliveryMethod fulltext_linktorsrc
Discipline Medicine
Engineering
Biology
EISSN 1546-1696
EndPage 1131
ExternalDocumentID 32929264
Genre Research Support, Non-U.S. Gov't
Journal Article
Research Support, N.I.H., Extramural
Commentary
GrantInformation_xml – fundername: NCI NIH HHS
  grantid: U24 CA224370
GroupedDBID ---
-~X
.55
.GJ
0R~
123
29M
2FS
2XV
36B
39C
3V.
4.4
4R4
53G
5BI
5M7
5RE
5S5
70F
7X7
88A
88E
88I
8AO
8CJ
8FE
8FG
8FH
8FI
8FJ
8G5
8R4
8R5
A8Z
AAEEF
AAHBH
AAIKC
AAMNW
AARCD
AAYOK
AAYZH
AAZLF
ABAWZ
ABDBF
ABDPE
ABEFU
ABJCF
ABJNI
ABLJU
ABOCM
ABUWG
ACBTR
ACBWK
ACGFO
ACGFS
ACGOD
ACIWK
ACMJI
ACPRK
ACUHS
ADBBV
ADFRT
AENEX
AEUYN
AFANA
AFBBN
AFFNX
AFKRA
AFRAH
AFSHS
AGAYW
AGHTU
AHBCP
AHMBA
AHOSX
AHSBF
AIBTJ
ALFFA
ALIPV
ALMA_UNASSIGNED_HOLDINGS
AMTXH
ARMCB
ASPBG
AVWKF
AXYYD
AZFZN
AZQEC
BAAKF
BBNVY
BENPR
BGLVJ
BHPHI
BKKNO
BKOMP
BPHCQ
BVXVI
C0K
CCPQU
CGR
CUY
CVF
D1J
DB5
DU5
DWQXO
EAD
EAP
EAS
EBC
EBS
ECM
EE.
EIF
EJD
EMB
EMK
EMOBN
ESX
EXGXG
F5P
FA8
FEDTE
FQGFK
FSGXE
FYUFA
GNUQQ
GUQSH
GX1
HCIFZ
HMCUK
HVGLF
HZ~
IAG
IAO
IEA
IEP
IH2
IHR
INH
INR
IOV
ISR
ITC
KOO
L6V
LGEZI
LK8
LOTEE
M0L
M1P
M2O
M2P
M7P
M7S
ML0
MVM
N95
NADUK
NEJ
NNMJJ
NPM
NXXTH
O9-
ODYON
P2P
PKN
PQQKQ
PROAC
PSQYO
PTHSS
Q2X
QF4
QM4
QN7
QO4
RNS
RNT
RNTTT
RVV
RXW
SHXYY
SIXXV
SJN
SNYQT
SOJ
SV3
TAE
TAOOD
TBHMF
TDRGL
TN5
TSG
TUS
U5U
UKHRP
X7M
XI7
XOL
Y6R
YZZ
ZGI
ZHY
ZXP
~KM
7QO
7QP
7QR
7T7
7TK
7TM
7XB
8FD
8FK
ABFSG
ACSTC
AEZWR
AFFHD
AFHIU
AGSTI
AHWEU
AIXLP
ALPWD
ATHPR
C1K
FR3
K9.
MBDVC
P64
PHGZM
PHGZT
PJZUB
PKEHL
PPXIY
PQEST
PQGLB
PQUKI
PRINS
Q9U
RC3
7X8
ID FETCH-LOGICAL-c618t-865a10e09bcb8384e8e455e2db42eea80a272451ae2b2fa2e127991d4114bef13
IEDL.DBID M7P
ISICitedReferencesCount 40
ISICitedReferencesURI http://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=Summon&SrcAuth=ProQuest&DestLinkType=CitingArticles&DestApp=WOS_CPL&KeyUT=000569290100001&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D
ISSN 1087-0156
1546-1696
IngestDate Sun Nov 09 10:53:51 EST 2025
Sat Nov 29 14:25:59 EST 2025
Wed Feb 19 02:29:01 EST 2025
IsDoiOpenAccess false
IsOpenAccess true
IsPeerReviewed true
IsScholarly true
Issue 10
Language English
LinkModel DirectLink
MergedId FETCHMERGED-LOGICAL-c618t-865a10e09bcb8384e8e455e2db42eea80a272451ae2b2fa2e127991d4114bef13
Notes SourceType-Scholarly Journals-1
ObjectType-Commentary-1
content type line 14
ObjectType-Article-1
ObjectType-Feature-2
content type line 23
ORCID 0000-0002-5859-1064
0000-0001-7067-8966
0000-0003-4692-4797
OpenAccessLink https://www.nature.com/articles/s41587-020-0686-x.pdf
PMID 32929264
PQID 2476763995
PQPubID 47191
PageCount 5
ParticipantIDs proquest_miscellaneous_2442848978
proquest_journals_2476763995
pubmed_primary_32929264
PublicationCentury 2000
PublicationDate 2020-10-01
PublicationDateYYYYMMDD 2020-10-01
PublicationDate_xml – month: 10
  year: 2020
  text: 2020-10-01
  day: 01
PublicationDecade 2020
PublicationPlace United States
PublicationPlace_xml – name: United States
– name: New York
PublicationTitle Nature biotechnology
PublicationTitleAlternate Nat Biotechnol
PublicationYear 2020
Publisher Nature Publishing Group
Publisher_xml – name: Nature Publishing Group
SSID ssj0006466
Score 2.5600624
Snippet Can traditional computational analysis and machine learning help compensate for inadequate peer review of drug-repurposing papers in the context of an...
SourceID proquest
pubmed
SourceType Aggregation Database
Index Database
StartPage 1127
SubjectTerms Artificial Intelligence
Computational Biology - trends
Computer applications
COVID-19 - drug therapy
Drug Repositioning - trends
Humans
Learning algorithms
Machine learning
Pandemics
Peer Review
Title Artificial intelligence, drug repurposing and peer review
URI https://www.ncbi.nlm.nih.gov/pubmed/32929264
https://www.proquest.com/docview/2476763995
https://www.proquest.com/docview/2442848978
Volume 38
WOSCitedRecordID wos000569290100001&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D
hasFullText 1
inHoldings 1
isFullTextHit
isPrint
link http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwpV07T8MwED7RFhAMPMqrUKogMRI18SN2JgSoFQMtEQ-pW-XEDuqSlqZF8O-xnbR0gYXlpDxsWb7L-V75DuDSwynVrrRy41j7qoRgrQcFom4ceglOhanCsCCuD6zf54NBGJUBt7wsq1zoRKuo5TgxMfI2Iixg5jil15N313SNMtnVsoVGBWoGJQHb0r1oqYmDIlfpe9yUV9JgkdXEvJ3rg8vcRbbtSuB-_m5h2pOmu_vfNe7BTmljOjeFUOzDmsrqsFF0nfyqw_YKBmEdNntldv0AQjOiQJRwRitQnVeOnM7fnKmaaK6MTXDBEZl0JnoKp_j15RBeu52Xu3u3bK3gJoHPZy4PqPA95YVxEnPMieKKUKqQjAlSSnBPIIYI9YVCMUoFUj5i2pKURLtPsUp9fATVbJypE3BCM0gwxCWTRFIptMkleZAyYaDeJG5Ac7FZw_L7yIc_O9WAi-VjLdkmXSEyNZ6bd7RrRLh2cxtwXDBkOCkgOIYYabNO23Knf09-BlvIsNgW3zWhOpvO1TmsJx-zUT5tQYUNmKW8BbXbTj960lc99Ghp1LLCZOmzpv2o9w2y7cy-
linkProvider ProQuest
linkToHtml http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMw1V3JTsQwDLXYlwPLsA1rkOBGResmbXpACLEIxDDiABK3kjYp4tIZZmH5Kb4Rp50CF7hx4No0llq_OM-xYwPsuH4myJU2TpKQr8q5T3ZQoXCSyE39TNksjKKIayNsNuXdXXQ9BO_VXRibVlnZxMJQ61Zqz8j3kYdBaLdTcdh-cmzXKBtdrVpolLC4NG8v5LJ1Dy5OSL-7iGenN8fnzqCrgJMGnuw5MhDKc40bJWkifcmNNFwIgzrhaIySrsIQufCUwQQzhcbDkEiU5uQ5JCbzfJI7DKNEI1AWqYLXn5Y_KGOjnittOqcIqiiqL_e7tFHap1i0eQmc158ZbbGznc3-t38yBzMDDs2OStDPw5DJazBedtV8q8H0txqLNZi4GmQPLEBkZ5QVM9jjt1Kke0x3-g-sY9qEupY9PGEq16xNIlh5tWcRbv_kg5ZgJG_lZgVYZCepEKUONddCK6KUWgZZqGwpO-3XYb1STjxY_934SzN12P4cppVrwzEqN62-fYdcPy7Jja_DcgmAuF2WGIl9JNpKXHX1d-FbMHl-c9WIGxfNyzWYQguvItFwHUZ6nb7ZgLH0uffY7WwWQGVw_9co-ADgMSHr
linkToPdf http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMw1V25TsQwEB1xCwqO5VpOI0FHtIljx06BEAJWIGC1BUh0wYkdtE122YPj1_g6xjmABjoK2ji2lMx4Ds_zG4B91085ptLGiWPMVRnz0Q4qyp04dBM_VRaFkZO4XotWS97fh-0xeK_uwlhYZWUTc0Otu4k9I29QJgJh3SlvpCUson3WPO49ObaDlK20Vu00ChW5Mm8vmL4Nji7PUNYHlDbPb08vnLLDgJMEnhw6MuDKc40bxkksfcmMNIxzQ3XMqDFKuooKyrinDI1pqqjxqMCASjPMImKTej6uOw6TwpKW57DB9qcXCIo6qedKC-3kQVVR9WVjgE7TPqV5y5fAef05us29XHPhP_-fRZgvY2tyUmyGJRgzWQ2mi26bbzWY-8a9WIOZmxJVsAyhnVEwaZDON4rSQ6L7o0fSNz3Uxq49VCEq06SHS5Diys8K3P3JB63CRNbNzDqQ0E5SgkotNNNcKww1tQxSoSzFnfbrsFUJKirtwiD6klId9j6HcUfbMo3KTHdk38GUkElM7-uwVihD1CuoRyKfYjiLMezG74vvwgwKP7q-bF1twiy1mpbjD7dgYtgfmW2YSp6HnUF_J9dZAg9_rQQfGGUqqA
openUrl ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Artificial+intelligence%2C+drug+repurposing+and+peer+review&rft.jtitle=Nature+biotechnology&rft.date=2020-10-01&rft.pub=Nature+Publishing+Group&rft.issn=1087-0156&rft.eissn=1546-1696&rft.volume=38&rft.issue=10&rft.spage=1127&rft.epage=1131&rft_id=info:doi/10.1038%2Fs41587-020-0686-x&rft.externalDBID=HAS_PDF_LINK
thumbnail_l http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=1087-0156&client=summon
thumbnail_m http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=1087-0156&client=summon
thumbnail_s http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=1087-0156&client=summon