Strategies for efficient production of recombinant proteins in Escherichia coli: alleviating the host burden and enhancing protein activity

Escherichia coli , one of the most efficient expression hosts for recombinant proteins (RPs), is widely used in chemical, medical, food and other industries. However, conventional expression strains are unable to effectively express proteins with complex structures or toxicity. The key to solving th...

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Bibliographic Details
Published in:	Microbial cell factories Vol. 21; no. 1; pp. 1 - 18
Main Authors:	Zhang, Zi-Xu, Nong, Fang-Tong, Wang, Yu-Zhou, Yan, Chun-Xiao, Gu, Yang, Song, Ping, Sun, Xiao-Man
Format:	Journal Article
Language:	English
Published:	London BioMed Central 15.09.2022 BioMed Central Ltd Springer Nature B.V BMC
Subjects:	Applied Microbiology Bacterial proteins Binding sites Biotechnology Chemistry Chemistry and Materials Science E coli Engineering research Enzymes Enzymology Escherichia coli Fermentation Food industry Genetic Engineering Genomes Gram-positive bacteria Host burden Inclusion bodies Methods Microbial Genetics and Genomics Microbiological synthesis Microbiology Mutation Optimization Physiological aspects Post-translational modification Production capacity Production processes Protein biosynthesis Protein engineering Protein expression Protein folding Proteins Recombinant protein Recombinant proteins Review RNA polymerase Toxicity China Post-translational modification Recombinant protein Inclusion bodies Host burden
ISSN:	1475-2859, 1475-2859
Online Access:	Get full text
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