Cancer Metabolism: The Role of ROS in DNA Damage and Induction of Apoptosis in Cancer Cells

Cancer is a huge challenge for people worldwide. High reactive oxygen species (ROS) levels are a recognized hallmark of cancer and an important aspect of cancer treatment research. Abnormally elevated ROS levels are often attributable to alterations in cellular metabolic activities and increased oxi...

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Vydáno v:Metabolites Ročník 13; číslo 7; s. 796
Hlavní autoři: Zhao, Yongxia, Ye, Xiaochun, Xiong, Zhifeng, Ihsan, Awais, Ares, Irma, Martínez, Marta, Lopez-Torres, Bernardo, Martínez-Larrañaga, María-Rosa, Anadón, Arturo, Wang, Xu, Martínez, María-Aránzazu
Médium: Journal Article
Jazyk:angličtina
Vydáno: Switzerland MDPI AG 27.06.2023
MDPI
Témata:
Apoptosis
Biosynthesis
Cancer
cancer metabolism
Cancer therapies
Care and treatment
Cell growth
Colorectal cancer
Diagnosis
DNA damage
Genetic aspects
Health aspects
Homeostasis
Inflammation
Kinases
Metabolism
Mortality
Mutation
Oxidation
Oxidative stress
Physiology
Reactive oxygen species
Review
ROS
Signal transduction
Tumors
China
cancer metabolism
apoptosis
cancer
DNA damage
oxidative stress
ROS
ISSN:2218-1989, 2218-1989
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Shrnutí:Cancer is a huge challenge for people worldwide. High reactive oxygen species (ROS) levels are a recognized hallmark of cancer and an important aspect of cancer treatment research. Abnormally elevated ROS levels are often attributable to alterations in cellular metabolic activities and increased oxidative stress, which affects both the development and maintenance of cancer. Moderately high levels of ROS are beneficial to maintain tumor cell genesis and development, while toxic levels of ROS have been shown to be an important force in destroying cancer cells. ROS has become an important anticancer target based on the proapoptotic effect of toxic levels of ROS. Therefore, this review summarizes the role of increased ROS in DNA damage and the apoptosis of cancer cells caused by changes in cancer cell metabolism, as well as various anticancer therapies targeting ROS generation, in order to provide references for cancer therapies based on ROS generation.
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ISSN:2218-1989
2218-1989
DOI:10.3390/metabo13070796