Monitoring Incidence of COVID-19 Cases, Hospitalizations, and Deaths, by Vaccination Status — 13 U.S. Jurisdictions, April 4–July 17, 2021

COVID-19 vaccine breakthrough infection surveillance helps monitor trends in disease incidence and severe outcomes in fully vaccinated persons, including the impact of the highly transmissible B.1.617.2 (Delta) variant of SARS-CoV-2, the virus that causes COVID-19. Reported COVID-19 cases, hospitali...

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Bibliographic Details
Published in:MMWR. Morbidity and mortality weekly report Vol. 70; no. 37; pp. 1284 - 1290
Main Authors: Scobie, Heather M., Johnson, Amelia G., Suthar, Amitabh B., Severson, Rachel, Alden, Nisha B., Balter, Sharon, Bertolino, Daniel, Blythe, David, Brady, Shane, Cadwell, Betsy, Cheng, Iris, Davidson, Sherri, Delgadillo, Janelle, Devinney, Katelynn, Duchin, Jeff, Duwell, Monique, Fisher, Rebecca, Fleischauer, Aaron, Grant, Ashley, Griffin, Jennifer, Haddix, Meredith, Hand, Julie, Hanson, Matt, Hawkins, Eric, Herlihy, Rachel K., Hicks, Liam, Holtzman, Corinne, Hoskins, Mikhail, Hyun, Judie, Kaur, Ramandeep, Kay, Meagan, Kidrowski, Holly, Kim, Curi, Komatsu, Kenneth, Kugeler, Kiersten, Lewis, Melissa, Lyons, B. Casey, Lyons, Shelby, Lynfield, Ruth, McCaffrey, Keegan, McMullen, Chelsea, Milroy, Lauren, Meyer, Stephanie, Nolen, Leisha, Patel, Monita R., Pogosjans, Sargis, Reese, Heather E., Saupe, Amy, Sell, Jessica, Sokol, Theresa, Sosin, Daniel, Stanislawski, Emma, Stevens, Kelly, Vest, Hailey, White, Kelly, Wilson, Erica, MacNeil, Adam, Ritchey, Matthew D., Silk, Benjamin J.
Format: Journal Article Newsletter
Language:English
Published: Atlanta Centers for Disease Control & Prevention (CDC) 17.09.2021
U.S. Government Printing Office
U.S. Center for Disease Control
Centers for Disease Control and Prevention
Subjects:
Age groups
Complications and side effects
Coronaviruses
COVID-19
COVID-19 vaccines
Death & dying
Deaths
Effectiveness
Full Report
Hospitalization
Immunization
Infection
Infections
Jurisdiction
Monitoring
Public health
Robust control
Sensitivity analysis
Severe acute respiratory syndrome
Severe acute respiratory syndrome coronavirus 2
Surveillance
Trends
Vaccination
Vaccine efficacy
Vaccines
Viral diseases
Maryland
United States > US
ISSN:0149-2195, 1545-861X, 1545-861X
Online Access:Get full text
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Summary:COVID-19 vaccine breakthrough infection surveillance helps monitor trends in disease incidence and severe outcomes in fully vaccinated persons, including the impact of the highly transmissible B.1.617.2 (Delta) variant of SARS-CoV-2, the virus that causes COVID-19. Reported COVID-19 cases, hospitalizations, and deaths occurring among persons aged ≥18 years during April 4-July 17, 2021, were analyzed by vaccination status across 13 U.S. jurisdictions that routinely linked case surveillance and immunization registry data. Averaged weekly, age-standardized incidence rate ratios (IRRs) for cases among persons who were not fully vaccinated compared with those among fully vaccinated persons decreased from 11.1 (95% confidence interval [CI] = 7.8-15.8) to 4.6 (95% CI = 2.5-8.5) between two periods when prevalence of the Delta variant was lower (<50% of sequenced isolates; April 4-June 19) and higher (≥50%; June 20-July 17), and IRRs for hospitalizations and deaths decreased between the same two periods, from 13.3 (95% CI = 11.3-15.6) to 10.4 (95% CI = 8.1-13.3) and from 16.6 (95% CI = 13.5-20.4) to 11.3 (95% CI = 9.1-13.9). Findings were consistent with a potential decline in vaccine protection against confirmed SARS-CoV-2 infection and continued strong protection against COVID-19-associated hospitalization and death. Getting vaccinated protects against severe illness from COVID-19, including the Delta variant, and monitoring COVID-19 incidence by vaccination status might provide early signals of changes in vaccine-related protection that can be confirmed through well-controlled vaccine effectiveness (VE) studies.COVID-19 vaccine breakthrough infection surveillance helps monitor trends in disease incidence and severe outcomes in fully vaccinated persons, including the impact of the highly transmissible B.1.617.2 (Delta) variant of SARS-CoV-2, the virus that causes COVID-19. Reported COVID-19 cases, hospitalizations, and deaths occurring among persons aged ≥18 years during April 4-July 17, 2021, were analyzed by vaccination status across 13 U.S. jurisdictions that routinely linked case surveillance and immunization registry data. Averaged weekly, age-standardized incidence rate ratios (IRRs) for cases among persons who were not fully vaccinated compared with those among fully vaccinated persons decreased from 11.1 (95% confidence interval [CI] = 7.8-15.8) to 4.6 (95% CI = 2.5-8.5) between two periods when prevalence of the Delta variant was lower (<50% of sequenced isolates; April 4-June 19) and higher (≥50%; June 20-July 17), and IRRs for hospitalizations and deaths decreased between the same two periods, from 13.3 (95% CI = 11.3-15.6) to 10.4 (95% CI = 8.1-13.3) and from 16.6 (95% CI = 13.5-20.4) to 11.3 (95% CI = 9.1-13.9). Findings were consistent with a potential decline in vaccine protection against confirmed SARS-CoV-2 infection and continued strong protection against COVID-19-associated hospitalization and death. Getting vaccinated protects against severe illness from COVID-19, including the Delta variant, and monitoring COVID-19 incidence by vaccination status might provide early signals of changes in vaccine-related protection that can be confirmed through well-controlled vaccine effectiveness (VE) studies.
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ISSN:0149-2195
1545-861X
1545-861X
DOI:10.15585/mmwr.mm7037e1