Endothelial progenitor cells in cardiovascular disorders

The important role of the vascular endothelium in cardiovascular health is increasingly recognized. However, mature endothelial cells possess limited regenerative capacity. There is therefore much interest in circulating endothelial progenitor cells (EPCs) among the scientific community, especially...

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Bibliographic Details
Published in:Journal of the American College of Cardiology Vol. 49; no. 7; p. 741
Main Authors: Shantsila, Eduard, Watson, Timothy, Lip, Gregory Y H
Format: Journal Article
Language:English
Published: United States 20.02.2007
Subjects:
Aging - pathology
Animals
Cardiovascular Agents - therapeutic use
Cardiovascular Diseases - physiopathology
Cardiovascular Diseases - therapy
Disease Models, Animal
Endothelial Cells - cytology
Endothelial Cells - drug effects
Endothelial Cells - pathology
Humans
Neovascularization, Physiologic
Risk Factors
Stem Cell Transplantation - methods
Stem Cells - cytology
Stem Cells - drug effects
Stem Cells - pathology
Treatment Outcome
ISSN:1558-3597, 1558-3597
Online Access:Get more information
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Summary:The important role of the vascular endothelium in cardiovascular health is increasingly recognized. However, mature endothelial cells possess limited regenerative capacity. There is therefore much interest in circulating endothelial progenitor cells (EPCs) among the scientific community, especially into their purported role in maintenance of endothelial integrity and function, as well as postnatal neovascularization. It has been suggested that these cells might not only be responsible for the continuous recovery of the endothelium after injury/damage, but also might take part in angiogenesis, giving the hope of new treatment opportunities. Indeed, there is accumulating evidence showing reduced availability and impaired EPC function in the presence of both cardiovascular disease and associated comorbid risk factors. Thus, many studies into the potential for use of EPCs in the clinical setting are being undertaken. The goal of this review article is to provide an overview of data relevant to the clinical role of EPCs and perspectives for treatment of cardiovascular disorders.
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ISSN:1558-3597
1558-3597
DOI:10.1016/j.jacc.2006.09.050